关键词: 帕金森障碍; 帕金森病; 微量化学

Abstract: Objective The aim of the study is to investigate the level of four trace elements, including copper(Cu), selenium (Se), zinc (Zn) and lead (Pb) in blood for the patients with vascular parkinsonism(VP) and Parkinson’s disease (PD).Methods The level of Cu, Zn and Pb in blood were measured in 20 VP patients, 17 PD patientsand 10 control subjects by graphite furnace atomic absorption spectrophotometer and Se in bloodby fluorophotometry.Results (1) The total level of Cu and Se in blood were significantly higher than that of control group(P <0.05) and no significant difference was found between VP and PD groups (P >0.05). (2) The totallevel of Zn and Pb in blood for VP and PD groups were not significantly different when comparedwith control group (P >0.05). (3) The level of Cu, Se and Zn in blood were all significantly higherthan that of control group (P <0.05) in VP patients with duration <5 years, whereas Cu and Zn weresignificantly lower than that of control group (P <0.05) in those with duration >5 years. (4) Thelevel of Cu, Se and Zn in blood were all significantly higher than that of control group (P <0.05) inPD patients who were in stage of I-II, whereas Cu and Pb were significantly higher, and Se and Znwere significantly lower than that of control group (P <0.05) in PD patients who were in stage ofIII-V.Conclusion The overall level of Cu and Se in blood were obviously high. Elevated levels of Cu, Seand Zn in blood were found in VP patients with duration <5 years and declined levels of Cu and Znin those with duration >5 years. The enhanced levels of Cu, Se and Zn in blood were observed inPD patients who were in the stage of I-II, the increased levels of Cu and Pb, and dropped levels ofSe and Zn were showed in those who were in stage of III-V. The trace elements might play a pivotalrole in the pathogenesis, progression and prognosis of VP and PD.

Key words: Parkinsonian disorders; Parkinson disease; Microchemistry