关键词: 脑梗死; 尤瑞克林; 随机对照试验; Meta分析

Abstract: Objective To assess the efficacy of Urinary Kallid for patients with acute cerebral infarction.Methods We searched CBMdisc (1978～2010), CNKI (1979～2010), VIP (1989～2010), Wanfang Database (1978～2010) by electronic database and relevant journals such as Chinese Journal ofNeurology, Journal of Clinical Neurology, Journal of Apoplexy and Nervous Diseases and ChineseJournal of Clinical Neurosciences etc. by manual searching to collect all randomized controlledtrials (RCTs) and quasi-randomized controlled trials (quasi-RCTs) of Urinary Kallid for patientswith acute cerebral infarction. The quality of included studies was assessed according to the criteriarecommended by the Cochrane Handbook for Systematic Reviews of Interventions and data wereextracted by two reviewers independently. Meta-analysis was conducted by RevMan 5.0 software.Results Fifty-seven studies involving 5273 patients were included. The results of meta-analysisshowed that: 1. The incidence of aggravated rate in the Urinary Kallid group was lower than that inthe control group (RR =0.38, 95%CI 0.27 to 0.52, P <0.01); 2. There were no differences betweenthe two groups in the incidence of mortality (RR =0.47, 95%CI 0.13 to 1.73, P =0.26); 3. There weresignificant differences between the two groups in the influence of Barthel Index (BI) (WMD=7.97,95%CI 3.34 to 12.6, P =0.0007); 4. There were significant differences between the two groups in theinfluence of The National Institutes of Health Stroke Scale (NIHSS) (WMD=-2.37, 95%CI -2.95 to-1.79, P <0.01); 5. The incidence of adverse reaction in the Urinary Kallid group was higher than thatin the control group, but the degree was slight, symptomatic treatment could make the syndromesrelieving.Conclusion Urinary Kallid shows an effective reduction in the incidence of aggravated rate, itcan improve BI and NIHSS. There are no differences between the two groups in the incidence ofmortality, and the incidence of adverse reaction in the Urinary Kallid group is higher than that inthe control group, but has no influence in treatment.

Key words: Brain infarction; Urinary Kallid; Randomized controlled trial; Meta-analysis