关键词: 脑梗死; 二级预防; 氯吡格雷; 阿司匹林

Abstract: Objective To appraise the therapeutic efficacy and the safety of clopidogrel and aspirin in thesecondary prevention of ischemic cerebral stroke.Methods The patients with ischemic stroke were randomly divided into the clopidogrel groupand the aspirin group. Fifty-five patients were continuously collected for each group. Patients inthe clopidogrel group received clopidogrel 50mg once daily. Patients in the aspirin group receivedaspirin enteric-coated tablets 75mg once daily. The patients of the two groups have been followedup for one year; and the recurrences rate of ischemic stroke and the adverse drug reaction rates ofthe two groups were compared.Results The recurrences rate in the aspirin group is 13.5%, and the clopidogrel group is1.8%, the recurrences rates in the clopidogrel group is lower than that in the aspirin group(P =0.04); the adverse drug reaction rate in the aspirin group is 36.4%, and the clopidogrelgroup is 5.5%, the adverse drug reaction rate in the clopidogrel is lower that in the aspiringroup (P =0.001).Conclusion The therapeutic efficacy and the safety of clopidogrel in secondary prevention ofischemic stroke is better than aspirin.

Key words: Brain infarction; Secondary prevention; Clopidogrel; Aspirin