关键词: 小血管病; 脑白质病变; 认知功能

Abstract:

Objective To assess the correlation of the white matter lesions and the cognitive function of the patients with small vessel disease. Methods The patients with small vessel disease were chosen from all the outpatients of the Department of Neurology in First Affiliated Hospital of the Medical College of Zhejiang University from October 2009 to December 2009, by the assessments of cognitive function, such as the informant questionnaire on cognitive decline in the elderly(IQCODE), the Mini-Mental State Examination(MMSE), the Clinical Dementia Rating(CDR) and so on, the cerebral magnatic resonance imaging(MRI) and the clinical data. The effect of the different extents and locations of the white matter lesions to the cognitive function was assessed by statistical analysis. Results A total of 147 patients were included in this study, with 33 small vessel disease. Comparing with the normal group, significant differences(P =0.00) were found in the patients with small vessel disease in the remembrance(z =-3.36), the orientation(z =-3.14), the judgement(z =-3.38) and the social activity(z =-3.22). We found significant correlations between the scores of MMSE(r =0.82),the remembrance scores of CDR(r =0.82), the total scores of CDR(r =0.62)and the extent of the periventricular lesions(P =0.00), but the correlations between the deep white matter lesions and the cognitive impairment were middling correlated, as the scores of MMSE(r =0.51, P =0.01), the remembrance scores of CDR(r =0.49, P =0.02). Conclusions The scores of MMSE and the CDR may be predictors to the progress of the white matter lesion, especially the periventricular lesions.

Key words: Small vessel disease; White matter lesion; Cognition function