中国卒中杂志 ›› 2013, Vol. 8 ›› Issue (02): 147-152.

• 综述 • 上一篇    下一篇

大脑老化与神经再生和卒中

张红霞1,邵蓓1,王柳清1,林真珍1,肖丽1,蒋慧刚1,程一帆1,苏巧尔1,郑伟明2,诸葛启钏2,   

  1. 1325000 温州
    温州医学院附属第一医院神经内科
    2温州医学院附属第一医院神经外科
    3Department of Pharmacology and Neuroscience,University of North Texas Health Science Center
  • 收稿日期:2012-02-04 出版日期:2013-02-20 发布日期:2013-02-20
  • 通讯作者: 金坤林 kunlin.jin@unthsc.edu
  • 基金资助:

    国家自然基金
    (2011,81171088)

Neurogenesis, Stroke and Brain Aging

  • Received:2012-02-04 Online:2013-02-20 Published:2013-02-20

摘要:

大脑老化是神经退行性疾病的主要诱因。而卒中不仅是老年人的神经系统常见疾病,而且也是70岁以上老年人致残和死亡的重要原因,因此,大脑老化与卒中发病息息相关。已经证实,老年卒中患者其缺血性脑组织损伤更加严重、脑梗死面积更大、缺血后的神经功能障碍也更加显著。尽管研究已证实老龄大脑的神经再生减少,但卒中可以诱导神经再生并能有效促进神经功能恢复,这就为神经再生治疗卒中开辟了良好的途径。本文重点就大脑老化及老化后神经再生、缺血性卒中作一简要综述。

文章导读: 【点睛】
本文简要介绍大脑老化及老化后神经再生、缺血性卒中的研究进展。

关键词: 神经再生; 老化; 神经干细胞

Abstract:

Brain aging, a common induced factor of neurodegenerative diseases, is associated with a striking increase in the incidence of stroke, which is a common disease of the nervous system and a major cause of disability and death among those aged 70 years and older. It is well documented that there are more serious brain ischemic changes, larger infarction area and more significant nerve dysfunction in elderly. Although many studies have confirmed decreased neurogenesis in aging brain, increased neurogenesis after stroke holds great promise for brain repair. This review seeks to integrate briefly what is known about neurogenesis and ischemic stroke after brain aging.

Key words: Neurogenesis; aging; Ischemic stroke; Neural stem cells