1 Hachinski VC, Potter P, Merskey H. Leukoaraiosis[J]. Arch Neurol, 1987, 44:21-23.2 潘婕, 罗本燕. 小血管病性脑白质病变与认知功能障碍关系研究[J]. 中国卒中杂志, 2012, 7:762 -768.3 Grueter BE, Schulz UG. Age-related cerebral white matter disease(leukoaraiosis):a review[J]. Postgrad Med J, 2012, 88:79-87.4 Choi HS, Cho YM, Kang JH, et al. Cerebral white matter hyperintensity is mainly associated with hypertension among the components of metabolic syndrome in Koreans[J]. Clin Endocrinol(Oxf), 2009, 71:184-188.5 van Dijk EJ, Prins ND, Vrooman HA, et al. Progression of cerebral small vessel disease in relation to risk factors and cognitive consequences:Rotterdam Scan study[J]. Stroke, 2008, 39:2712-2719.6 Streifler JY, Eliasziw M, Benavente OR, et al. Development and progression of leukoaraiosis in patients with brain ischemia and carotid artery disease[J]. Stroke, 2003, 34:1913 -1916.7 Tanaka T, Shimizu T, Fukuhara T. The relationship between leukoaraiosis volume and parameters of carotid artery duplex ultrasonographic scanning in asymptomatic diabetic patients[J]. Comput Med Imaging Graph, 2009, 33:489-493.8 Kivipelto M, Ngandu T, Laatikainen T, et al. Risk score for the prediction of dementia risk in 20 years among middle aged people:a longitudinal, population-based study[J]. Lancet Neurol, 2006, 5:735-741.9 Sierra C, Coca A. White matter lesions and cognitive impairment as silent cerebral disease in hypertension[J]. Scientific World Journal, 2006, 6:494-501.10 Vuorinen M, Solomon A, Rovio S, et al. Changes in vascular risk factors from midlife to late life and white matter lesions:a 20-year follow-up study[J]. Dement Geriatr Cogn Disord, 2011, 31:119-125.11 Huang YH, Zhang WW, Lin L, et al. Could changes in arterioles impede the perivascular drainage of interstitial fluid from the cerebral white matter in leukoaraiosis?[J]. Neuropathol Appl Neurobiol, 2010, 36:237-247.12 Kuller LH, Margolis KL, Gaussoin SA, et al. Women's Health Initiative Memory Study Research Group. Relationship of hypertension, blood pressure, and blood pressure control with white matter abnormalities in the Women's Health Initiative Memory Study(WHIMS)-MRI trial[J]. J Clin Hypertens(Greenwich), 2010, 12:203-212.13 Brickman AM, Reitz C, Luchsinger JA, et al. Long-term blood pressure fluctuation and cerebrovascular disease in an elderly cohort[J]. Arch Neurol, 2010, 67:564-569.14 Anan F, Masaki T, Iwao T, et al. The role of microalbuminuria and insulin resistance as significant risk factors for white matter lesions in Japanese type 2 diabetic patients[J]. Curr Med Res Opin, 2008, 24:1561-1567.15 Shimomura T, Anan F, Umeno Y, et al. Hyperhomocysteinaemia is a significant risk factor for white matter lesions in Japanese type 2 diabetic patients[J]. Eur J Neurol, 2008, 15:289-294.16 Park JH, Ryoo S, Kim SJ, et al. Differential risk factors for lacunar stroke depending on the MRI(white and red) subtypes of microangiopathy[J]. PLoS One, 2012, 7:e44865.17 Kim BJ, Lee SH, Kaug BS, et al. Diabetes increases large artery diseases, but not small artery diseases in the brain[J]. Neurology, 2008, 225:1176-1181.18 Weinger K, Jacobson AM, Musen G, et al. The effects of type l diabetes on cerebral white matter[J]. Diabetologia, 2008, 5l:417-425. 19 Khan U, Hassan A, Vallance P, et al. Asymmetric dimethylarginine in cerebral small vessel disease[J]. Stroke, 2007, 38:411-413.20 Feng C, Bai X, Xu Y, et al. Hyperhomocysteinemia associates with small vessel disease more closely than large vessel disease[J]. Int J Med Sci, 2013, 10:408-412.21 Pavlovic AM, Pekmezovic T, Obrenovic R, et al. Increased total homocysteine level is associated with clinical status and severity of white matter changes in symptomatic patients with subcortical small vessel disease[J]. Clin Neurol Neurosurg, 2011, 113:711-715.22 Kloppenborg RP, Nederkoorn PJ, vander Graaf Y, et al. Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study[J]. Atherosclerosis, 2011, 216:461-466.23 Turaj W, Iskra T, Pulyk R, et al. Plasma homocysteine concentration in patients with ischaemic stroke caused by large or small vessel disease[J]. Pol Merkur Lekarski, 2009, 26:121-124.24 Quadri P, Fragiacomo C, Pezzati R, et al. Homocysteine, folate, and vitamin B-12 in mild cognitive impairment, Alzheimer disease, and vascular dementia[J]. Am J Clin Nutr, 2004, 80:114-122.25 Pantoni L, Garcia JH.Pathogenesis of leukoaraiosis[J]. Stroke, 1997, 28:652-657.26 Pantoni L. Pathophysiology of age-related cerebral white matter changes[J]. Cerebrovascular Diseases, 2002, 13:7-10.27 Nonaka H, Akima M, Hatori T, et al. Microvasculature of the human cerebral white matter:arteries of the deep white matter[J]. Neuropathology, 2003, 23:111-118.28 Gottesman RF, Coresh J, Catellier DJ, et al. Blood pressure and white-matter disease progression in a biethnic cohort:Atherosclerosis Risk in Communities(ARIC) study[J]. Stroke, 2010, 41:3-8.29 Markus HS, Lythgoe DJ, Ostegaard L, et al. Reduced white matter CBF in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI[J]. J Neurol Neurosurg Psychiatry, 2000, 69:48-53.30 Bastos-Leite AJ, Kuijer JP, Rombouts SA, et al. Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities[J]. AJNR Am J Neuroradiol, 2008, 29:1296-1301.31 Inzitari M, Studenski S, Rosano C, et al. Anemia is associated with the progression of white matter disease in older adults with high blood pressure:the cardiovascular health study[J]. J Am Geriatr Soc, 2008, 56:1867-1872.32 Simpson JE, Ince PG, Higham CE, et al. Microglial activation in white matter lesions and nonlesional white matter of ageing brains[J]. Neuropathol Appl Neurobiol, 2007, 33:670-683.33 Farrall AJ, Wardlaw JM. Blood-brain barrier:ageing and microvascular disease systematic review and meta-analysis[J]. Neurobiol Aging, 2009, 30:337-352.34 Wallin A, Sjögren M, Edman A, et al. Symptoms, vascular risk factors and blood-brain barrier function in relation to CT white-matter changes in dementia[J]. Eur Neurol, 2000, 44:229-235.35 Simpson JE, Wharton SB, Cooper J, et al. Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain[J]. Neurosci Lett, 2010, 486:246-251.36 Szolnoki Z. Pathomechanism of leukoaraiosis:a molecular bridge between the genetic, biochemical, and clinical processes(a mitochondrial hypothesis)[J]. Neuromolecular Med, 2007, 9:21-33.37 Paternoster L, Chen W, Sudlow CL. Genetic determinants of white matter hyperintensities on brain scans:a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects[J]. Stroke, 2009, 40:2020-2026.38 Simpson JE, Hosny O, Wharton SB, et al. Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways[J]. Stroke, 2009, 40:369-375.39 Xu H, Stamova B, Jickling G, et al. Distinctive RNA expression profiles in blood associated with white matter hyperintensities in brain[J]. Stroke, 2010, 41:2744-2749. |