中国卒中杂志 ›› 2014, Vol. 9 ›› Issue (04): 303-308.

• 专题综述 • 上一篇    下一篇

基因指导下的抗凝治疗

吴岩峰,丁红,刘庆萍,王辉   

  1. 210003 南京
    南京医科大学第二附属
    医院神经内科
  • 收稿日期:2013-11-11 出版日期:2014-04-20 发布日期:2014-04-20
  • 通讯作者: 王辉 wsn69@sina.com

Genetic Polymorphisms and Anticoagulation Therapy with Individualizing

  1. Department of Neurology, the Second
    Affiliated Hospital of Nanjing Medical University, Nanjing 210003, China
  • Received:2013-11-11 Online:2014-04-20 Published:2014-04-20

摘要:

抗凝治疗是急性冠状动脉综合征、心房颤动、静脉血栓形成、肺栓塞等栓塞类疾病非常 有效的治疗手段。抗凝药物包括肝素、华法林、达比加群、利伐沙班、阿哌沙班等。抗凝药物剂量个 体差异大、出血风险高。如何提高抗凝治疗的有效性和安全性作为目前的研究热点。基因多态性在 抗凝药物的剂量效应关系方面起了非常重要的作用。本文旨在探讨影响华法林、达比加群等抗凝药 物的遗传因素,为个体化治疗提供依据

文章导读: 抗凝药物的基因组学影响抗凝治疗的剂量效应关系,可以为急性冠状动脉综合征、心房颤动、静脉
血栓形成、肺栓塞等栓塞类疾病的个体化治疗提供依据。

关键词: 抗凝治疗; 华法林; 达比加群; 基因多态性

Abstract:

Anticoagulation therapy is currently prescribed for treatment on thrombotic disorders, such as acute coronary syndromes, atrial fibrillation, vein thrombosis, pulmonary embolism. Currently, anticoagulants include heparin, warfarin, dabigatran, rivaroxaban, apixaban and so on. However, anticoagulants vary in dose on individual patient. One of the hot researches is how to increase the efficacy and safety of anticoagulation. Genetic polymorphisms are thought to contribute to the wide intraindividual variability in anticoagulant drug response. Here, we review the genetic mechanisms contributing to the variability in response to warfarin and dabigatran, and propose the personal management of anticoagulation therapy.

Key words: Anticoagulation therapy; Warfarin; Dabigatran; Genetic polymorphisms