关键词: 华法林; 阿司匹林; 心房颤动; 低强度抗凝

Abstract:

Objective  To explore the efficacy and safety of low intensity warfarin in the elderly patients with nonvalvular atrial fibrillation in the prevention of cerebral embolism. Methods  We consecutively enrolled 80 patients who were diagnosed nonvalvular atrial fibrillation with treatment duration＞1 year, admitted to Department of Cardiology and Department of Geriatrics of Beijing Tiantan Hospital from January 2010 to January 2014. The patients were divided into low intensity warfarin treatment group (40 patients) and aspirin treatment control group (40 patients), and international normalized ratio of low intensity warfarin treatment group was controlled within the range of 1.6~2.5. The incidence of ischemic stroke and major hemorrhage    were compared between both groups. Results  There were no significant differences between the two groups in age, sex and complications. The incidence of cardioembolic stroke in low intensity warfarin treatment group was 2.5%, 7.5% in aspirin treatment control group, there was no significant difference (P＞0.05). There were no other organ embolisms in low intensity warfarin treatment group, but only one in aspirin treatment control group, but with no significant difference (P＞0.05). There were no severe cerebral hemorrhage, renal hemorrhage, and bleeding from the other organs in both groups. Conclusion  Low-intensity warfarin in the prevention of stroke in patients with non-valvular atrial fibrillation stroke in terms of efficacy and safety may be comparable to aspirin.

Key words: Warfarin; Aspirin; Atrial fibrillation; Low intensity anticoagulation