超声评估中国健康成年人视神经鞘直径

摘要/Abstract

摘要：

目的确定中国正常成人视神经鞘直径（optic nerve sheath diameter，ONSD）的参考值范围，并且探索与其相关的影响因素。方法以2013年1月-2014年1月健康体检的成年人作为研究对象，每位受试者的双眼视神经鞘的矢状位和横断面均由两位医生分别测量两次。每位受试者ONSD的最终报告值是双眼视神经鞘的16个测量值的平均值。结果共有230例受试者，获得3680个ONSD测量值，范围为2.65～4.30 mm。ONSD的上限值低于以往白种人及黑人的研究结果。简单线性回归分析发现ONSD与性别、体质指数（body mass index，BMI）、腰围、头围相关。在调整了其他可能的影响因素后发现性别（偏回归系数0.189，P<0.001）、BM（I 偏回归系数0.032，P <0.001）是ONSD的独立影响因素。低体重组的女性ONSD最小。结论在确立ONSD的正常值标准时应考虑种族、性别、BMI的差别。

关键词: 视神经鞘直径; 超声; 颅内压

Abstract:

The aim of the work described here was to establish the range for optic nerve sheath diameter (ONSD) and potential factors influencing ONSD in healthy Chinese adults. Both ONSDs were measured twice in the sagittal and transversal planes by two observers. The final ONSD value for each participant was the average of 16 measurements of both eyes. The ONSD range (N =3680) among 230 participants was 2.65~4.30 mm. The upper ONSD limit was lower than those in previous studies in Caucasian and African samples. Simple linear regression analyses revealed that the ONSD was correlated with sex, body mass index and waistline and head circumference. After adjustment for potential confounds between these factors, sex (coefficient=0.225, P <0.001) and body mass index (coefficient=0.042, P <0.001) were independently associated with ONSD. Underweight women had the smallest ONSD. These results suggest that racial, sex, and body mass index differences should be noted when assessing ultrasonographic criteria.

Key words: Optic nerve sheath diameter; Ultrasonography; Intracerebral pressure

王丽娟, 冯良枢, 姚燕, 邓方, 王玉芝, 冯加纯, 邢英琦. 超声评估中国健康成年人视神经鞘直径 [J]. 中国卒中杂志, 2016, 11(07): 556-562.

WANG Li-Juan, FENG Liang-Shu, YAO Yan, et al.. Ultrasonographic Evaluation of Optic Nerve Sheath Diameter among Healthy Chinese Adults[J]. Chinese Journal of Stroke, 2016, 11(07): 556-562.

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