卒中杂志 ›› 2012, Vol. 7 ›› Issue (12): 941-947.
林真珍,王柳清,邵蓓
收稿日期:
2012-02-11
出版日期:
2012-12-20
发布日期:
2012-12-20
基金资助:
出血性脑卒中大鼠hNSCs脑内移植后新生血管生成与运动功能恢复之机制研究——国家自然基金(2011,81171088)
Received:
2012-02-11
Online:
2012-12-20
Published:
2012-12-20
林真珍,王柳清,邵蓓. 缺血性卒中后血管新生的细胞和分子调节机制[J]. 卒中杂志, 2012, 7(12): 941-947.
LIN Zhen-Zhen,WANG Liu-Ling,SHAO Bei,. Cellular and Molecular Mechanisms Underlying Regulation of Angiogenesis after Ischemic Stroke[J]. Chinese Journal of Stroke, 2012, 7(12): 941-947.
1 Lain W, Graham L. Essential Neurology[M]. Oxford:Blackwell Publishing Ltd, 2005:25-26.2 Font MA, Arboix A, Krupinski J. Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke[J]. Curr Cardiol Rev, 2010, 6:238-244.3 Lafuente JV, Ortuzar N, Bengoetxea H, et al. Vascular endothelial growth factor and other angioglioneurins:key molecules in brain development and restoration[J]. Int Rev Neurobiol, 2012, 102:317-346.4 Pettersson A, Nagy JA, Brown LF, et al. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor[J]. Lab Invest, 2000, 80:99-115.5 Sun Y, Jin K, Xie L, et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia[J]. J Clin Invest, 2003, 111:1843-1851.6 Jin K, Zhu Y, Sun Y, et al. Vascular endothelial growth factor(VEGF) stimulates neurogenesis in vitro and in vivo[J]. Proc Natl Acad Sci USA, 2002, 99:11946-11950.7 Zhang ZG, Zhang L, Jiang Q, et al. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain[J]. J Clin Invest, 2000, 106:829-838.8 Margaritescu O, Margaritescu C, Piric D. VEGF expression in human brain tissue after acute ischemic stroke[J]. Rom J Morphol Embryol, 2011, 52:1283-1292.9 van Bruggen N, Thibodeaux H, Palmer JT, et al. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain[J]. J Clin Invest, 1999, 104:1613-1620.10 Marti H J, Bernaudin M, Bellail A, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia[J]. Am J Pathol, 2000, 156:965-976.11 Ingraham JP, Forbes ME, Riddle DR, et al. Aging reduces hypoxia-induced microvascular growth in the rodent hippocampus[J]. J Gerontol A Biol Sci Med Sci, 2008, 63:12-20.12 Rivard A, Berthou-Soulie L, Principe N, et al. Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity[J]. J Biol Chem, 2000, 275:29643-29647.13 Emerich DF, Schneider P, Bintz B, et al. Aging reduces the neuroprotective capacity, VEGF secretion, and metabolic activity of rat choroid plexus epithelial cells[J]. Cell Transplant, 2007, 16:697-705.14 Gao P, Shen F, Gabriel RA, et al. Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice[J]. Stroke, 2009, 40:3596-3600.15 Sonntag WE, Lynch CD, Cooney PT, et al. Decreases in cerebral microvasculature with age are associated with the decline in growth hormone and insulin-like growth factor 1[J]. Endocrinology, 1997, 138:3515-3520.16 Cheng J, Liu J, Li X, et al. Insulin-like growth factor-1 receptor polymorphism and ischemic stroke:a case-control study in Chinese population[J]. Acta Neurol Scand, 2008, 118:333-338.17 Denti L, Annoni V, Cattadori E, et al. Insulin-like growth factor 1 as a predictor of ischemic stroke outcome in the elderly[J]. Am J Med, 2004, 117:312-317.18 De Smedt A, Brouns R, Uyttenboogaart M, et al. Insulin-like growth factor I serum levels influence ischemic stroke outcome[J]. Stroke, 2011, 42:2180-2185.19 Zhu W, FanY F, Hao Q, et al. Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke[J]. J Cereb Blood Flow Metab, 2009, 29:1528-1537.20 Gospodarowicz D. Expression and control of vascular endothelial cells:proliferation and differentiation by fibroblast growth factors[J]. J Invest Dermatol, 1989, 93:39S-47S.21 Cheng X, Wang Z, Yang J, et al. Acidic fibroblast growth factor delivered intranasally induces neurogenesis and angiogenesis in rats after ischemic stroke[J]. Neurol Res, 2011, 33:675-680.22 Gabra N, Khayat A, Calabresi P, et al. Detection of elevated basic fibroblast growth factor during early hours of in vitro angiogenesis using a fast ELISA immunoassay[J]. Biochem Biophys Res Commun, 1994, 205:1423-1430.23 Issa R, Alqteishat A, Mitsios N, et al. Expression of basic fibroblast growth factor mRNA and protein in the human brain following ischaemic stroke[J]. Angiogenesis, 2005, 8:53-62.24 Won SJ, Xie L, Kim SH, et al. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke[J]. Brain Res, 2006, 1123:234-244.25 Lee SW, Kim WJ, Jun HO, et al. Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregulation of ZO-2[J]. Int J Mol Med, 2009, 23:279-284. 26 Baffert F, Le T, Thurston G, et al. Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules[J]. Am J Physiol Heart Circ Physiol, 2006, 290:H107-118.27 Zhao Y, Li Z, Wang R, et al. Angiopoietin 1 counteracts vascular endothelial growth factor-induced blood-brain barrier permeability and alleviates ischemic injury in the early stages of transient focal cerebral ischemia in rats[J]. Neurol Res, 2010, 32:748-55.28 Shen F, Walker FJ, Jiang L, et al. Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume[J]. J Cereb Blood Flow Metab, 2011, 31:2343-2351.29 Hansen TM, Moss AJ, Brindle NP. Vascular endothelial growth factor and angiopoietins in neurovascular regeneration and protection following stroke[J]. Curr Neurovasc Res, 2008, 5:236-245.30 Chen J, Yu H, Song W, et al. Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population[J]. Clin Sci(Lond), 2009, 117:387-395.31 Lin TN, Wang CK, Cheung WM, et al. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion[J]. J Cereb Blood Flow Metab, 2000, 20:387-395.32 Lacombe C, Mayeux P. Biology of erythropoietin[J]. Haematologica, 1998, 83:724-732.33 Buemi M, Cavallaro E, Floccari F, et al. The pleiotropic effects of erythropoietin in the central nervous system[J]. J Neuropathol Exp Neurol, 2003, 62:228-236.34 Bikfalvi A, Han ZC. Angiogenic factors are hematopoietic growth factors and vice versa[J]. Leukemia, 1994, 8:523-529.35 Pelletier L, Regnard J, Fellmann D, et al. An in vitro model for the study of human bone marrow angiogenesis:role of hematopoietic cytokines[J]. Lab Invest, 2000, 80:501-511.36 Ribatti D, Vacca A, Roncali L, et al. Hematopoiesis and angiogenesis:a link between two apparently independent processes[J]. J Hematother Stem Cell Res, 2000, 9:13-19.37 Sirén AL, Knerlich F, Poser W, et al. Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain[J]. Acta Neuropathol, 2001, 101:271-276.38 Li L, Jiang Q, Ding G, et al. MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia[J]. Stroke, 2009, 40:936-941.39 Ding G, Jiang Q, Li L, et al. Cerebral tissue repair and atrophy after embolic stroke in rat:a magnetic resonance imaging study of erythropoietin therapy[J]. J Neurosci Res, 2010, 88:3206-3214.40 Chen ZY, Hendriks RW, Jobling MA, et al. Isolation and characterization of a candidate gene for Norrie disease[J]. Nat Genet, 1992, 1:204-208.41 Rehm HL, Zhang DS, Brown MC, et al. Vascular defects and sensorineural deafness in a mouse model of Norrie disease[J]. J Neurosci, 2002, 22:4286-4292.42 Hsieh M, Boerboom D, Shimada M, et al. Mice null for Frizzled4(Fzd4-/-) are infertile and exhibit impaired corpora lutea formation and function[J]. Biol Reprod, 2005, 73:1135-1146.43 Luhmann UF, Meunier D, Shi W, et al. Fetal loss in homozygous mutant Norrie disease mice:a new role of Norrin in reproduction[J]. Genesis, 2005, 42:253-262.44 Daneman R, Agalliu D, Zhou L, et al. Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis[J]. Proc Natl Acad Sci USA, 2009, 106:641-646.45 Liebner S, Corada M, Bangsow T, et al. Wnt/beta-catenin signaling controls development of the blood-brain barrier[J]. J Cell Biol, 2008, 183:409-417.46 Stenman JM, Rajagopal J, Carroll TJ, et al. Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature[J]. Science, 2008, 322:1247-1250.47 Goodwina M, Kitajewski J, D'amore PA. Wnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not[J]. Growth Factors, 2007, 25:25-32.48 Zerlin M, Julius MA, Kitajewski J. Wnt/Frizzled signaling in angiogenesis[J]. Angiogenesis, 2008, 11:63-69.49 Cirone P, Lin S, Griesbach HL, et al. A role for planar cell polarity signaling in angiogenesis[J]. Angiogenesis, 2008, 11:347-360.50 Hellstrom M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis[J]. Nature, 2007, 445:776-780.51 Hofmann JJ, Luisa Iruela-Arispe M. Notch expression patterns in the retina:An eye on receptor-ligand distribution during angiogenesis[J]. Gene Expr Patterns, 2007, 7:461-470.52 Benedito R, Roca C, Sorensen I, et al. The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis[J]. Cell, 2009, 137:1124-1135.53 Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling[J]. Genes Dev, 2007, 21:2511-2524.54 Sainson RC, Aoto J, Nakatsu MN, et al. Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis[J]. FASEB J, 2005, 19:1027-1029.55 Suchting S, Freitas C, Le Noble F, et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching[J]. Proc Natl Acad Sci USA, 2007, 104:3225-3230.56 Williams CK, Li JL, Murga M, et al. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function[J]. Blood, 2006, 107:931-939.57 Leslie JD, Ariza-Mcnaughton L, Bermange AL, et al. Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis[J]. Development, 2007, 134:839-844.58 Stoltz JF, Muller S, Kadi A, et al. Introduction to endothelial cell biology[J]. Clin Hemorheol Microcirc, 2007, 37(1-2):5-8.59 Asahara T, Murohara T, Sullivan A, et al. Isolation of putative progenitor endothelial cells for angiogenesis[J]. Science, 1997, 275(5302):964-967.60 Teng H, Zhang ZG, Wang L, et al. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke[J]. J Cereb Blood Flow Metab, 2008, 28:764-771.61 Chen J, Sanberg PR, Li Y, et al. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats[J]. Stroke, 2001, 32:2682-2688.62 Taguchi A, Soma T, Tanaka H, et al. Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesis in a mouse model[J]. J Clin Invest, 2004, 114:330-338.63 Hess DC, Hill WD, Martin-Studdard A, et al. Bone marrow as a source of endothelial cells and NeuN-expressing cells After stroke[J]. Stroke, 2002, 33:1362-1368.64 Asahara T, Masuda H, Takahashi T, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization[J]. Circ Res, 1999, 85:221-228.65 Sobrino T, Hurtado O, Moro MA, et al. The increase of circulating endothelial progenitor cells after acute ischemic stroke is associated with good outcome[J]. Stroke, 2007, 38:2759-2764.66 Yip HK, Chang LT, Chang WN, et al. Level and value of circulating endothelial progenitor cells in patients after acute ischemic stroke[J]. Stroke, 2008, 39:69-74.67 Ferrara N, Alitalo K. Clinical applications of angiogenic growth factors and their inhibitors[J]. Nat Med, 1999, 5:1359-1364.68 Simons M. Angiogenesis:where do we stand now?[J]. Circulation, 2005, 111:1556-1566. |
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