细胞外囊泡与缺血性卒中

doi:10.3969/j.issn.1673-5765.2018.04.013

摘要/Abstract

摘要：

目前，卒中是全世界范围内死亡和致残的主要原因之一。最新的研究发现细胞外囊泡（extracellular vesicle，EV），通过水平转移母体细胞的蛋白质和核酸，参与细胞间通讯并调节受体细胞的生物学功能。EV介导的细胞间通讯与卒中的发生、发展密切相关，并逐步成为卒中防治研究的热点。本文就EV内含物的分子组成与生物学功能在缺血性卒中发生、发展中的作用做简要综述。

文章导读： 细胞外囊泡介导的细胞间通讯与缺血性卒中的发生、发展密切相关，本文综述了细胞外囊泡及其内含信使RNA、蛋白质等生物大分子在脑血管再生、神经再生、神经重塑以及认知障碍中的作用机制，为进一步阐明缺血性卒中的发生、发展以及细胞外囊泡在卒中后脑组织重塑中的作用提供了新的思路。

关键词: 卒中; 细胞外囊泡; 细胞间通讯

Abstract:

Nowadays, stroke is one of the leading causes of death and disability worldwide. Recent studies suggest that extracellular vesicles (EV) play an important role in intercellular communication by transferring their components including protein, RNA and DNA between source and target cells in the brain. The transferred components in EVs can regulate the biological functions of the recipient cells, and participate in the pathogenesis of stroke, which gradually become the study hotspot in stroke prevention and treatment. This paper is to review these advances and their impact of EV molecular composition and biological function on ischemic stroke.

Key words: Stroke; Extracellular vesicle; Intercellular communication

蔡晋, 资文杰, 刘新峰. 细胞外囊泡与缺血性卒中[J]. 中国卒中杂志, 2018, 13(04): 372-376.

CAI Jin, ZI Wen-Jie, LIU Xin-Feng. Extracellular Vesicles and Ischemic Stroke[J]. Chinese Journal of Stroke, 2018, 13(04): 372-376.

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