水通道蛋白4与卒中后认知障碍的关系研究进展

doi:10.3969/j.issn.1673-5765.2022.12.017

摘要/Abstract

摘要： 卒中后认知障碍是卒中的重要后遗症之一，从病理上可以分为血管性、退变性及混合性认知障碍。水通道蛋白4广泛分布于中枢神经系统，参与多种神经系统疾病和认知障碍的病理过程，但其参与卒中后认知障碍的具体机制目前尚未明确。本文综述水通道蛋白4通过参与调节神经炎症、突触可塑性以及β-淀粉样蛋白的积聚和清除过程在卒中后认知障碍中发挥的可能作用。

文章导读： 目前的研究认为AQP4可能通过调节神经炎症、突触可塑性和Aβ的积聚和清除过程参与PSCI的病理过程，是未来可能治疗PSCI的干预靶点。

关键词: 水通道蛋白4; 卒中后认知障碍; 炎症因子; β-淀粉样蛋白

Abstract: Post-stroke cognitive impairment is one of the main sequelae of stroke, which can be divided into vascular, degenerative and mixed cognitive impairment. Aquaporin 4 is widely distributed in the central nervous system and is involved in the pathological process of cognitive impairment and multiple nervous system diseases. However, the specific mechanism of aquaporin 4 in post-stroke cognitive impairment is not clear. This article reviewed the possible important role of aquaporin 4 in post-stroke cognitive impairment by involvement in the regulation of neuroinflammation, synaptic plasticity, and the accumulation and clearance of β-amyloid.

Key words: Aquaporin 4; Post-stroke cognitive impairment; Inflammatory factor; β-amyloid

梁潇, 钱海兵. 水通道蛋白4与卒中后认知障碍的关系研究进展[J]. 中国卒中杂志, 2022, 17(12): 1385-1390.

LIANG Xiao, QIAN Haibing. Progress of the Relationship between Aquaporin 4 and Post-Stroke Cognitive Impairment[J]. Chinese Journal of Stroke, 2022, 17(12): 1385-1390.

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