关键词: 高半胱氨酸; 卒中; 叶酸; 维生素B12

Abstract: Objective To investigate the relationship between heperhomocysteinemia (Hcy) and stroke.Methods 102 patients with stroke (66 with cerebral infarction and 36 with cerebral hemorrhage) were included as the case group, while 102 subjects without stroke matched with the case group on gender, age and race were selected as control group. Hcy were measured by high-performance liquid chromatography and fluorescence detection. Levels of folate, Vitamin B12, blood glucose and Plasma lipid were measured as well.Results Plasma level of Hcy in case group was significantly higher than that in control group[(20±9)μmol/L vs (9±6)μmol/L, P<0.01], but it showed no significant difference between patients with cerebral infarction and patients with cerebral hemorrhage(P>0.05). Significant negative correlation were observed between plasma level of Hcy and plasma level of folate, as well as vitamin B12. Based on Logistic regression model, the odds ratio(OR) of hyperhomocysteinemia was 4.875 (95%CI 1.902-8.552) for stroke.Conclusion Hyperhomocysteinemia is an independent risk factor for strok. Deficiency of plasma folate and vitamin B12 may be one of reasons of hyperhomocysteinemia.

Key words: Homocysteine; Stroke; Folate; Vitamin B12