Chinese Journal of Stroke ›› 2017, Vol. 12 ›› Issue (08): 748-752.DOI: 10.3969/j.issn.1673-5765.2017.08.022

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A Review of the Research on Mechanisms of Mitophagy and Its Prospect in Cerebral Ischemia Stroke

  

  • Received:2017-03-31 Online:2017-08-20 Published:2017-08-20

线粒体自噬在缺血性卒中的机制研究与展望

关瑞桥,邹伟,孙晓伟,于学平,张莑,袁梦飞,戴晓红,滕伟,于薇薇   

  1. 1150040 哈尔滨黑龙江中医药大学临床医学院
    2黑龙江中医药大学附属第一医院神经内科
    3北京王府中西医结合医院中医科
  • 通讯作者: 邹伟 kuangzou1965@163.com
  • 基金资助:

    国家自然科学基金青年基金(81503669)
    黑龙江省自然科学基金面上项目(H2015031)
    哈尔滨市科技创新人才研究专项基金(2014RFQGJ054)
    黑龙江省政府博士后资助项目(LBH-ZI2248)

Abstract:

Mitophagy is a cellular process of clearing damaged mitochondrion by autophagy, which is an important mechanism of mitochondrion quality control. Recent years of research have suggested that there was obvious mitophagy process during the cerebral ischemia stroke (CIS). Mitophagy as a mechanism of regulating and controlling the quality and quantity of mitochondrion was significant to the CIS, it might have contribution to delaying molecular death and protecting neurons after stroke. This review is to introduce the effectiveness of mitophagy in the pathologic process of CIS, and its research progress and the forecast of therapeutic effect of mitophagy in the CIS.

Key words: Autophagy; Mitophagy; Ischemia stroke; PINK1-Parkin; NIX/BNIP3; FUNDC 1

摘要:

线粒体自噬是细胞通过自噬清除破坏的线粒体的过程,是线粒体质量控制的重要机制。 近年来研究表明,缺血性卒中后存在明显的线粒体自噬。因此在卒中过程当中,调节控制线粒体数量 和质量的线粒体自噬过程,可能对治疗卒中、延缓细胞死亡、保护神经元有十分关键的意义。本文主 要对线粒体自噬在缺血性卒中病理过程中的作用与机制,以及其目前的研究进展进行综述,并对线 粒体自噬对缺血性卒中的治疗作用进行展望。

关键词: 自噬; 线粒体自噬; 缺血性卒中; PINK Parkin; NIX/BNIP3; FUNDC 1