Abstract: Granulocyte colony-stimulating factor(G-CSF)is mainly used to treat neutropeniainduced by all causes. Recent investigations indicate that G-CSF can be used in cardio-protectiveand neuroprotective field. This article discusses the G-CSF’s origin, structure, source, signaltransducer pathway and neuroprotective mechanism. G-CSF and its receptor are expressed in ratbrain. In animal model of cerebral ischemia, G-CSF can reduce infarct volume and improve neuralfunctional recovery. The mechanism of these effects may include anti-inflammatory, anti-apoptosis,enhancing angiogenesis and neurogenesis.

Key words: Granulocyte colony-stimulating factor(G-CSF); Neuroprotection; CerebralInfarction

摘要： 粒细胞集落刺激因子（G-CSF）主要用于各种原因引起的粒细胞减少症。近年来的研究表明G-CSF 可用于心肌保护和神经保护等领域。本文主要对G-CSF 的由来、结构、来源、信号传导途径及神经保护作用机制进行综述。大鼠脑内存在G-CSF 及其受体表达，G-CSF 可以减小脑缺血动物模型的梗死灶，促进神经功能恢复，其作用机制可能包括抗炎症、抗凋亡、促进血管生成及神经发生等多种机制。

关键词: 粒细胞集落刺激因子; 神经保护; 脑梗死