Abstract: Objective To analyze the preliminary short-term outcome, especially the effect on cognitivefunction, and the safety of stenting for intracranial artery stenosis.Methods Patients with intracranial artery stenting were monitored by transcranial Dopplersonography(TCD), mini-mental state examination(MMSE) and P300 before and 1, 3 and 6 monthsafter stenting.Results Total 52 patients with atherosclerotic intracranial artery stenosis were enrolled in our study.24 stenosis in M1 segment of middle cerebral artery and 28 in intracranial vertebral artery. Technicalsuccess was achieved in all patients, with no procedure-associated complications. The residualstenosis(7%±5%) after stenting reduced significantly compared with pre-procedure stenosis(78％±10%). At 1, 3 and 6 months after stenting, the scores of MMSE were significantly higher and thelatent phase of P300 were shortened significantly (P <0.01), especially at 6 months. The patients hadno recurrent transient ischemia attach or stroke, and TCD revealed no restenosis during 6 monthsfollow-up.Conclusion Stenting of intracranial artery stenosis may be safe, feasible and favorable fordecreasing ischemic events and improving cognitive function during short-term follow-up. But theeffect of long-term will be studied further.

Key words: Intracranial artery stenosis; Stenting; Angioplasty; Cognitive function

摘要： 目的 观察血管内支架成形术治疗颅内动脉狭窄的安全性及短期疗效，尤其是对认知功能的影响。方法 观察52例症状性颅内动脉狭窄患者血管内支架成形术前后的经颅多普勒超声（TCD）改变、简易精神状态评估量表（MMSE）评分及P300的变化。结果 52例患者进行了颅内动脉支架成形术，其中大脑中动脉水平段24例，椎动脉28例。治疗前责任病变血管的狭窄率为78％±10%，治疗后的狭窄率为7％±5%。在治疗后随访的1、3及6个月，MMSE明显提高而P300明显缩短；而且随随访时间延长P300及MMSE变化越明显；随访期间患者没有短暂性脑缺血发作（TIA）及症状性脑梗死发生；经TCD随访，没有发现再狭窄。结论 血管内支架成形术能有效缓解颅内动脉狭窄并能改善短期认知功能，且是安全的。其长期效果有待进一步临床观察。

关键词: 颅内动脉狭窄; 支架; 血管成形术; 认知功能