Abstract:

The related papers werereviewedfordeepcomprehensionofthepathophysiology of full-scale constituent of neurovascular unit during the focal cerebral ischemia and reperfusion. The neurovascular unit is a concept framework thatconstitutes of cerebral microvascular endothelium, neuroepithelial cell, neurons, and the extracellular matrix. The comprehension of the concept and function of blood-brain barrier is useful for the understanding of neurovascular unit. All of the components of neurovascular unit will bdamagedduringtheschemia/reperfusion. The therapy effects of ischemicstrokecanbemprovedifmultipathoverallprotection forneurovascularunitisperformedduringthedifferentstagesofischemia/reperfusion.

Key words: Stroke; ischemic; Neurovascular unit; Blood-brain barrier

摘要：

为深入了解局部脑缺血/再灌注的病理生理过程中神经血管单元各个成分的病理反应，本文对相关文献作一综述。神经血管单元是由微血管、神经胶质细胞及其突起、神经元、细胞外基质组成的概念性框架，强调血脑屏障的概念和功能可加深对神经血管单元的理解。缺血/再灌注可损伤神经血管单元的各个成分，在缺血/再灌注的各阶段对神经血管单元的各成分实施多途径的全面保护，可进一步改善缺血性卒中的治疗效果。

关键词: 卒中; 缺血性; 神经血管单元; 血脑屏障