Table of Content

20 December 2007, Volume 2 Issue 12

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主编手记

Mystic Plateau

WANG Yong-jun

2007, 2(12):  963-964. 

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述评

Cerebrovascular Disease at High Altitude: A Special Domain of Neurology Needs to be Cared

WU Shi-zheng

2007, 2(12):  965-968. 

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论著

Relationship between Arterial Elasticity and Recurrence of Non-cardioCerebral Infarction in Plateau

HU Quan-zhong;WU Shi-zheng;WANG Li;et al

2007, 2(12):  969-971. 

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Objective To study the relationship between arterial elasticity(large artery elasticity index C1 and small artery elasticity index C2) and recurrence of non-cardiogenic cerebral infarction in plateau(2230 m).Methods Arterial elasticity of 342 patients with cerebral infarction were evaluated by HDI DO-2020 in plateau(2230 m). All the patients were followed for 12 months, and recurring prevalence of cerebral infarction was registered. Then we analyzed the relationship between cerebral infarction recurrence and arterial elasticity.Results In plateau recurring prevalence of cerebral infarction was 17.17%, but of lacunar infarction was 22.6%, signifcantly higher than cerebral infarction(P<0.05). Signifcantly decreased C2 was found in lacunar infarction (P<0.05), but the decrease was more obviously in recurring lacunar infarction (P<0.05). Logistic analysis showed there was correlation between C2 and recurring prevalence of lacunar infarction.Conclusion There is correlation between arterial elasticity and recurrence of non-cardiogenic lacunar infarction in plateau. Examination of C2 may be helpful to prevent and treat recurrence of cerebral infarction.

The Correlation with Hyperuricemia and Acute Ischemic Stroke at High Altitude

WANG Li;WU Shi-zheng;HU Quan-zhong;et al

2007, 2(12):  972-974. 

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Objective To observe the effects of hyperuricemia on acute ischemic stroke at high altitude.Methods We recruited 132 patients with acute ischemic stroke and 76 healthy volunteers. Blood uric acid (BUA), fasting blood glucose (FPG), total cholesterol (TC), triglyeride (TG) and low density lipoprotein-cholesterol (LDL-C) were tested after 12 hours of limosis.Results Compared with the normal cases, the level of BUA, FPG, TC, TG and LDL-C were signifcantly higher (P<0.05). After other risk factors were adjusted, the hyperuricemia appeared positive correlation with acute ischemic stroke (OR=1.004, 95%CI 1.001-1.008, P=0.022).Conclusion The hyperuricemia may be one of the risk factors of acute ischemic stroke at high altitude.

Prevention Effects of Percutaneous Transluminal Angioplasty with Smaller Diameter Balloon on Hemorrhagic Transformation after Acute Occlusion of Intracranial Arteries

HU Shen;SONG Wei-jian;YAN Jie-hao;et al

2007, 2(12):  975-978. 

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Objective To discuss the prevention effects of partial recanalization mainly by percutaneous transluminal angioplasty(PTA) with smaller diameter balloon or combining with low dose of Urokinase(UK) on hemorrhagic transformation after acute occlusion of anterior intracranial arteries.Methods We treated 38 cases with acute occlusion of anterior intracranial arteries by endovascular therapy, 16 cases by routine UK with microcatheter and microwire(control group), 22 cases by PTA with smaller diameter balloon or with low dose of UK(PTA group). We observed the frequency of recanalized hemorrhagic transformation and the prognosis in two groups.Results Recanalizing time was signifcantly shorter in PTA group than in control group(18.3±8.1 min vs. 63.9±18.9 min, P<0.01). Residue stenosis rate of less than 50% were 75.0%(12/16) for control group, 22.7%(5/22) for PTA group and there was signifcantly different between them(P<0.01). Total 7 of 38 patients suffered from hemorrhagic transformation, in which 4 cases occured in control group, 3 cases in PTA group, and 4 (3 in control group,1 in PTA group)of them needed surgery treatment with remaining severe dysfunction, but no one died because of hemorrhagic transformation.Conclusion Within therapy time window, partial recanalization mainly by PTA using smaller diameter balloon has active prophylactic effects on hemorrhagic transformation after acute occlusion of anterior intracranial arteries. It can largely elevate recanalizing rate and shorten recanalizing time, which is a good base for the following stent.

论文

The Effect of Transient Ischemic Attack on Cerebral Ischemic Tolerance

YANG Chuan-jun;FAN Ling

2007, 2(12):  979-981. 

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Objective To analyze the effect of transient ischemic attack(TIA) on cerebral ischemic tolerance.Methods Total 60 cases with cerebral infarction enrolled in our investigation, in which 30 cases had TIA within 72 hours as TIA group and 30 cases had no TIA history as control group.Results The TIA group had less cerebral infarction volume than control grou(8.2ml vs 10.6 ml, P<0.05), and had higher scores in European stroke scale(ESS) before treatment and after 15d, 30d, 90d treatment(62±22 vs 58±24, P<0.05; 70±28 vs 66±32, P<0.05; 80±20 vs 76±24, P<0.05; 82±18 vs 77±23, P<0.05).Conclusion TIA may improve cerebral ischemic tolerance and it has defnite clinical signifcance for decreasing the injury of brain cells in cerebral infarction.

论著

Application of MR Fast Imaging in Thrombolytic Therapy of Ultraacute Cerebral Infarction

QING Ke;ZHAO Zhen-guo;LI Yao-hua;et al

2007, 2(12):  982-985. 

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tissue-type plasminogen activator(rt-PA) intravenous injection and followed-up periodically by MR.Results The 7 patients with thrombolytic therapy had better outcome with Modifed Rankin Scale of 90d less than 2 and Barthal Index of 80-100 scores. Three weeks after thrombolytic therapy 1 patient had asymptomatic intracranial hemorrhage.Conclusion MR has great value in the screen and follow-up of thrombolytic therapy for the patients, especially for those who have undefned time window or more than 6 hours.

专题论坛

The Action of High Altitude Cerebral Edema in Cerebrovascular Disease at HighAltitude

HOU Qian;WU Shi-zheng;HU Quan-zhong;et al

2007, 2(12):  986-989. 

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Sleep Disordered Breathing and Stroke at High Altitude

CHEN Jian;WU Shi-zheng

2007, 2(12):  990-992. 

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病例讨论

Unilateral Moyamoya Disease Associated with Arteriovenous Malformation in a Young Patient: A Case Report

FENG Xiang-ying;WANG Zhan;FENG Tao

2007, 2(12):  993-994. 

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指南与规范

National Stroke Association Guidelines for the Management of Transient Ischemic Attacks

PU Yue-hua;QIN Hai-qiang;WANG Yi-long;et al

2007, 2(12):  995-1002. 

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综述

Progress of the Investigations of Neurovascular Unit Protection in Ischemic Stroke

CHEN Ping;CHEN Li-yun;WANG Yong-jun

2007, 2(12):  1003-1008. 

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The related papers werereviewedfordeepcomprehensionofthepathophysiology of full-scale constituent of neurovascular unit during the focal cerebral ischemia and reperfusion. The neurovascular unit is a concept framework thatconstitutes of cerebral microvascular endothelium, neuroepithelial cell, neurons, and the extracellular matrix. The comprehension of the concept and function of blood-brain barrier is useful for the understanding of neurovascular unit. All of the components of neurovascular unit will bdamagedduringtheschemia/reperfusion. The therapy effects of ischemicstrokecanbemprovedifmultipathoverallprotection forneurovascularunitisperformedduringthedifferentstagesofischemia/reperfusion.

国际研究动态

Thrombolysis with Alteplase for Acute Ischemic Stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST)

LUAN Jing-yu;WANG Yi-long

2007, 2(12):  1009-1014. 

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学术观点

The Effect of Aspirin on Prevention of Large Vascular Disease in Diabetes

ZHAO Lin;ZOU Da-jin

2007, 2(12):  1015-1019. 

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