Abstract: Objective To observe the effects of hyperuricemia on acute ischemic stroke at high altitude.Methods We recruited 132 patients with acute ischemic stroke and 76 healthy volunteers. Blood uric acid (BUA), fasting blood glucose (FPG), total cholesterol (TC), triglyeride (TG) and low density lipoprotein-cholesterol (LDL-C) were tested after 12 hours of limosis.Results Compared with the normal cases, the level of BUA, FPG, TC, TG and LDL-C were signifcantly higher (P<0.05). After other risk factors were adjusted, the hyperuricemia appeared positive correlation with acute ischemic stroke (OR=1.004, 95%CI 1.001-1.008, P=0.022).Conclusion The hyperuricemia may be one of the risk factors of acute ischemic stroke at high altitude.

Key words: Ischemic stroke; High altitude; Hyperuricemia

摘要： 目的 研究高原地区（海拔2260 m）高尿酸血症对急性脑梗死的影响。方法 选取急性脑梗死患者132例为观察组，同期健康体检者76例为对照组。测定空腹12 h后血尿酸（BUA）、血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）的水平。结果 病例组BUA、FPG、TC、TG、LDL-C均高于对照组（P均<0.05），在调整其他危险因素后，高尿酸血症与脑梗死仍呈正向相关（OR=1.004，95%CI 1.001～1.008， P=0.022）。结论 高尿酸血症可能是高原急性脑梗死的危险因素之一。

关键词: 脑梗死; 高原; 高尿酸血症