Abstract: Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, which was believed to be responsible for the increased morbidity and mortality associated with stroke. Reported evidences demonstrated that PSD was correlated with the lesion location as well as the severity of stroke, and was due to the multiple biopsychosocial factors. Controlled clinical trails have shown that antidepressants are efficient in the prevention and treatment of PSD. In this review we will provide an overview of several important issues on this field.

Key words: Depression; post-stroke; Epidemiology; Risk factors; Diagnosis; Treatment

摘要： 卒中后抑郁是卒中后最常见的神经精神并发症，对预后产生不良影响。目前认为卒中后抑郁与卒中病变部位和严重程度相关，是生物学因素和心理社会学因素共同作用的结果。已有临床研究证实抗抑郁药物能够有效预防和治疗卒中后抑郁。本文对卒中后抑郁相关热点问题作一简要回顾。

关键词: 抑郁; 卒中后; 流行病学; 危险因素; 诊断; 治疗