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Guidelines for the Establishment of Chinese Stroke Center National Center of Quality Improvement In Neurology, Health and Family Planning Commission, P.R.China Chinese Journal of Stroke    2015, 10 (06): 499-507.   Abstract （7319）      PDF （2173KB）（2880）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Guideline for Endovascular Treatment of Acute Ischemic Stroke 2023 Chinese Stroke Association, Chinese Interventional Neuroradiology Society, Intervention Group of Committee of Stroke Prevention and Control of Chinese Preventive Medicine Association Chinese Journal of Stroke    2023, 18 (06): 684-711.   DOI: 10.3969/j.issn.1673-5765.2023.06.010 Abstract （7188）      PDF （2089KB）（7657）       Knowledge map    Save Reference | Related Articles | Metrics

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China Stroke Statistics 2020 (1) WANG Yongjun, LI Zixiao, GU Hongqiu, ZHAI Yi, JIANG Yong, ZHOU Qi, ZHAO Xingquan, WANG Yilong, YANG Xin, WANG Chunjuan, MENG Xia, LI Hao, LIU Liping, JING Jing, WU Jing, XU Anding, DONG Qiang, David Wang, WANG Wenzhi, MA Xudong, ZHAO Jizong, China Stroke Statistics Writing Committee Chinese Journal of Stroke    2022, 17 (05): 433-447.   DOI: 10.3969/j.issn.1673-5765.2022.05.001 Abstract （5922）      PDF （5134KB）（2764）       Knowledge map    Save Related Articles | Metrics

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Chinese Stroke Association (CSA), Neurointervention Branch of CSA, Intervention Group, Professional Board of Stroke Prevention and Control, Chinese Preventive Medicine Association (CPMA) Chinese Journal of Stroke    2015, 10 (07): 590-606.   Abstract （5905）      PDF （2795KB）（3019）       Knowledge map    Save Reference | Related Articles | Metrics

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Consensus Statement of Evaluation and Management of Collateral Circulation after Ischemic Stroke Chinese Journal of Stroke    2013, 8 (04): 285-293.   Abstract （5706）      PDF （1508KB）（2016）       Knowledge map    Save Reference | Related Articles | Metrics

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Chronic Subjective Dizziness JU Yi, ZHAO Xing-Quan. Chinese Journal of Stroke    2013, 8 (05): 388-382.   Abstract （4942）      PDF （1830KB）（1879）       Knowledge map    Save Chronic subjective dizziness(CSD) is defined as a syndrome of chronic nonvertiginous dizziness or subjective imbalance accompanied by hypersensitivity to motion stimuli and poor tolerance for complex visual stimuli or precision visual tasks, all occurring in the absence of active vestibular deficits. Staab and Ruckenstein introduced this concept for the first time in 2004-2005 which reflected the relationship of psychological factors and other neuro-otologic disorders and it included three types(nerve-otologic, psychogenic and interactive). The treatments of CSD include medication, psychological therapy, vestibular rehabilitation and cognitive behavioral therapy. This article reviews the etiology, pathogenesis, clinical manifestations, diagnosis and treatments of CSD. Reference | Related Articles | Metrics

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Expert Consensus on Statins for Prevention and Treatment of Ischemic Stroke/Transient Ischemic Attack Expert Consensus Group of Statins for Prevention and Treatment of Ischemic Chinese Journal of Stroke    2013, 8 (07): 565-.   Abstract （4867）      PDF （2521KB）（1895）       Knowledge map    Save Reference | Related Articles | Metrics

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Hemodynamic Change of Childhood Moyamoya Disease after Multiple Burr-hole Operation    2008, 3 (07): 481-486.   Abstract （4643）      PDF （2914KB）（1527）       Knowledge map    Save Objective Using multicolor ultraphonic power Doppler to study the hemodynamic change of childhood moyamoya disease after multiple burr-hole operation, to know the effectiveness of the multiple burr-hole operation and to choose the best device of follow-up. Methods Eight children diagnosed with moyamoya disease underwent multiple burr-hole operations. And we used multicolor ultraphonic power Doppler assisting with single photon emission computed tomography (SPECT) to observe the hemodynamic change before and after the operations. Results Beginning at one week after operation, angiograms showed neovascularization, and 3 months after operation showed rich neovascularization. SPECT showed that the regional cerebral blood flow(rCBF) of homolateral hemisphere was improved at 3 months after burr-hole operation, but rCBF of opposite hemisphere decreased when compared with preoperation. Ischemic symptoms of all the patients improved after burr-operation. Conclusion After burr-hole operation, we can find rich new vessels and lateral branches through the holes. The burr-hole operation can improve the ischemia of childhood moyamoya disease; Doppler imaging is a valid noninvasive alternative to carotid artery angiography in evaluating direct and indirect revascularization. Related Articles | Metrics

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Chinese Consensus on Diagnosis and Therapy of Cerebral Small Vessel Disease 2021 Cerebral Small Vessel Disease Professional Committee Consensus Writing Group, Chinese Research Hospital Association Chinese Journal of Stroke    2021, 16 (07): 716-726.   DOI: 10.3969/j.issn.1673-5765.2021.07.013 Abstract （4393）      PDF （1984KB）（2304）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Experts Consensus on Endovascular Treatment for Symptomatic Intracranial Atherosclerotic Stenosis 2022 Chinese Stroke Association, Chinese Interventional Neuroradiology Society Chinese Journal of Stroke    2022, 17 (08): 863-888.   DOI: 10.3969/j.issn.1673-5765.2022.08.013 Abstract （4365）      PDF （2263KB）（1264）       Knowledge map    Save Reference | Related Articles | Metrics

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Chinese Stroke Association Guidelines for Clinical Management of Cerebrovascular Diseases (Second Edition) (Excerpt)——Chapter Four Clinical Management of Ischaemic Cerebrovascular Diseases Chinese Journal of Stroke    2023, 18 (8): 910-933.   DOI: 10.3969/j.issn.1673-5765.2023.08.009 Abstract （4286）      PDF （19848KB）（4357）       Knowledge map    Save The incidence of stroke in the Chinese population is still on the rise, accounting for nearly one-fourth of the global annual stroke cases. Among adults aged 40 or above in China, ischaemic stroke (IS) accounted for approximately 86.8% of all strokes. Since the publication of the 2019 Chinese Stroke Association guidelines, notable advancements have emerged in acute-phase reperfusion therapy and antiplatelet treatments for secondary prevention in IS. The guidelines have provided updated recommendations on evaluation and diagnosis of acute phase of ischaemic stroke, reperfusion therapy, antiplatelet therapy, other treatments in the acute phase, general supportive treatment and complications management, early evaluation and diagnosis of aetiology and pathogenesis, interventions targeting aetiology and pathogenesis, risk factors management, and long-term intervention. Related Articles | Metrics

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Experts Consensus on Multidisciplinary Management of Stroke-related Non-motor Symptoms Writing Committee of This Consensus Chinese Journal of Stroke    2023, 18 (03): 315-334.   DOI: 10.3969/j.issn.1673-5765.2023.03.011 Abstract （4217）      PDF （1810KB）（764）       Knowledge map    Save Related Articles | Metrics

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Analysis on Videonystagmography Parameters of Vestibular Central and Peripheral Vertigo Patients SUN Xiao-Ying*, ZHAO Xing-Quan, JU Yi. Chinese Journal of Stroke    2013, 8 (05): 346-350.   Abstract （4117）      PDF （2070KB）（1880）       Knowledge map    Save Objective To analyze the characteristics of videonystagmography(VNG) parameters of vestibular central and peripheral vertigo patients. Methods Data on clinical manifestations and parameters of VNG were collected from 69 cases of vestibular central vertigo and 108 cases of vestibular peripheral vertigo, and then these data were analyzed and compared respectively. Results Compared with patients with vestibular peripheral vertigo, those with vestibular central vertigo were more common in male(P<0.001), older(P=0.009), shorter in course(P<0.001). The symptoms of diplopia(P<0.001), hemianesthesia weakness(P<0.001), slurred speech(P<0.001) were more often in patients with vestibular central vertigo. And cochlear symptoms(P=0.021) were more frequent in patients with vestibular peripheral vertigo. The duration of vertigo attack of vestibular central vertigo was longer(P<0.001). The onset of vestibular central vertigo was more related to body position(P<0.001). As compared with patients with vestibular peripheral vertigo, those with vestibular central vertigo demonstrated more abnormal in eye tracking test(40.6% vs 0.9%, P<0.001), calibration test(13.0% vs 0.0%, P<0.001), optokinetic test(10.1% vs 0.0%, P=0.003), gaze test(10.1% vs 0.0%, P=0.003), spontaneous nystagmus(8.7% vs 0.0%, P=0.007) or positional nystagmus(8.7% vs 0.0%, P=0.007). And positive positioning test was more common in patients with vestibular peripheral vertigo(14.5% vs 74.1%, P<0.001). Conclusion The features of VNG parameters are objective responses of nystagmus in vestibular vertigo patients. Combined with clinical features, they could help us distinguish vestibular central and peripheral vertigo. Reference | Related Articles | Metrics

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Chinese Expert Consensus on Full Course Management of Stroke-Related Pain in Older Patients Rehabilitation Committee of Chinese Association of Rehabilitation Medicine, Community Committee of Chinese Association of Rehabilitation Medicine (Writers: HE Jieying, OU Jibing, JIA Jie) Chinese Journal of Stroke    2022, 17 (10): 1041-1050.   DOI: 10.3969/j.issn.1673-5765.2022.10.002 Abstract （4089）      PDF （2235KB）（261）       Knowledge map    Save Reference | Related Articles | Metrics

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The Study of Protection of Irb on Human Umbilical Vein Endothelial Cells Impaired by Lysophosphatidylcholine DAI Wen-Zhuo;SHI Jing-Ping;LIN Xing-Jian.    2008, 3 (10): 721-725.   Abstract （3844）      PDF （2076KB）（1259）       Knowledge map    Save Objective To investigate the protection effect of irbesartan on cultured human umbilical vein endothelial cells(HUVECs) impaired by lysophosphatidylcho-line(LPC).Methods HUVECs were cultured in vitro. The study was designated to 8 groups: (1)normal control, (2)low-concentration LPC group (10μg/L), (3)middle-concentration LPC group(20μg/L), (4) high-concentration LPC group (40μg/L), (5)Irb control group containing LPC(20μg/L),(6)low-concentration Irb group(10-7μmol/L),(7) middle-concentration Irb group(10-6μmol/L) ,(8) high-concentration Irb group(10-5μmol/L). Expression of angiotensin II (ATII) and ATII type1 receptor(AT1R), AT type2 receptor(AT2R) mRNA were observed by radio-immunity and RT-PCR respectively. Production of nitrogen monoxidum (NO), activity of nitricoxide synthase (NOS) and superoxide dismutase (SOD) were determined by chromatometry. Also the intervention effect of Irb was observed.Results Compared with normal control group, LPC could significantly up-regulate the expression of ATII and AT1R mRNA and decrease the expression of NO and the activity of NOS,SOD in a dose-dependent manner; Irb could significantly increase the expression of NO and the activity of NOS and SOD.Conclusion Irb could partly protect HUVECs function against the LPC-induced damage. Related Articles | Metrics

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Effect of Ginkgo Biloba Extract-EGb-761 on Beta Secrelase of Rat Hoppocampal Neurons undergoing Chronic Hypoxia and Hypoglycemia GUAN Xue-Neng;YAN Fu-Ling.    2008, 3 (08): 0-590.   Abstract （3756）      PDF （2077KB）（960）       Knowledge map    Save Objective To observe the effect of Ginkgo biloba extract EGb 761 on beta secretase of rathippocampal neurons undergoing chronic hypoxia and hypoglycemia and to explore the possiblemechanism of EGb 761 in the prevention and therapy of dementia.Methods Primary cultures of Wistar rat hippocampal neurons were prepared for the followingprocedures. At 7th day after cells plating, hippocampal neurons were treated with hypoxic andhypoglycemic culture alone or together with EGb 761(Ginaton 100ug/ml)pretreatment for 12h, 24h,and 36h respectively. Fluorescence detection and Western Blot were applied respectively to assaybeta secretase enzyme activity and protein expression.Results Beta secretase enzyme activity was higher in hypoxic and hypoglycemic groups at all timepoint than that in the control group(P <0.05) and pretreatment groups(P <0.05). Beta secretase proteinexpression in hypoxic and hypoglycemic groups was increased compared with the control group(P＜0.05) and compared with the pretreatment groups(P ＜0.05).Conclusion The beneficial influence of EGb 761 in the prevention and therapy of dementia may bemediated by the decrease of beta secretase enzyme activity and protein expression. Related Articles | Metrics

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Effect of Mild Hypothermia on the Expression of IL-6 and ICAM-1 in Rats with Focal Cerebral Ischemia FU Sheng-Qi;ZHANG Shu-Ling;FENG Lai-Hui;et al    2008, 3 (02): 104-108.   Abstract （3742）      PDF （2001KB）（93）       Knowledge map    Save Objective To investigate the effect of mild hypothermia on the expression of ICAM-1 in the ischemia area and on the serum level of IL-6 concentration after middle cerebral artery occlusion (MCAO) in rats.Methods Thirty female Sprague-Dawley rats weighing 250-300 g were randomly assigned to the experiment group(n=15)and the control group(n=15). The unilateral MCAO models of rats were made by using suture embolism. After successfully making the MCAO models, the experiment group and the control group were treated by mild hypothermia and normothermia, respectively. For the experiment group, temperature was maintained at(33±1) after10 minutes, and for the contrl group, temperature was kept at(37±0.5). Twelve hours after cerebral ischemia, 4ml blood was drawn from left ventricles, then the brain was immediately and carefully extracted in each rat. Immunohistochemistry analysis was used to count the number of ICAM-1 positive microvessel in the ischemia area, and immunoradiometric assay(IRA) was used to analyze the serum level of IL-6. Results The number of ICAM-1 positive microvessel in the ischemia area of brain in the experiment group were significantly less than that in the control group (2.45±1.56)/HP vs (18.27±2.45)/HP, (P<0.01), but the serum IL-6 concentration and the neurological severity score in the control group are obviously higher than in the experiment group[(184±38)ng/L vs (124±41) ng/L, P<0.01, (2.13±0.35) vs (1.48±0.25), P<0.01, respectively].Conclusion Mild hypothermia can reduce the serum IL-6 concentration and the ICAM-1 expression in ischemia area after cerebral ischemia. We presume that decreasing the expression of IL-6 and ICAM-1 is one of the neuroprotective mechanism in treating ischemic stroke by using mild hypothermia. Related Articles | Metrics

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Experts Consensus on Post-stroke Cognitive Impairment Management 2021 Chinese Society of Vascular Cognitive Impairment Chinese Journal of Stroke    2021, 16 (04): 376-389.   DOI: 10.3969/j.issn.1673-5765.2021.04.011 Abstract （3721）      PDF （1995KB）（1433）       Knowledge map    Save Reference | Related Articles | Metrics

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2008, 3 (06): 389-393.   Abstract （3682）      PDF （1231KB）（1930）       Knowledge map    Save Objective To investigate the effects of Bio-wave regulation factor (BRF) on tumor necrosis factor- α(TNF-α) expression in rats after middle cerebral artery occlusion (MCAO). Methods A total of 90 adult male Sprague-Dawley rats were randomly divided into sham operation group, normal saline group and BRF treatment group. Each group consisted of five subgroups (6h, 24h, 48h, 72h and 7d), according to different time points post-ischemia. Rats in BRF treatment group and normal saline group were subjected to MCAO and administrated intraperitoneally with 1.25% BRF solution (1ml/100g) and normal saline (1ml/100g) respectively sixty minutes after operation, then once a day till they were sacrificed. Four different methods were used for assessing neurological deficit score (NDS) , the wet-dry method for measuring brain water content, hematoxylin and eosin(HE) staining technique for observing histopathological changes, immunohistochemistry method for detecting TNF-α expression. Results 1. Behavioral evaluation: the behavioral outcomes were most serious at 48h, 72h and back to normal at 7d after MCAO. The NDS was lower in BRF treatment group than that of normal saline group at 48h. 2. Brain water content: Brain water contents both in normal saline group and BRF treatment group increased obviously at any points. Compared with normal saline group, brain edema in BRF treatment group was attenuated apparently, especially at 48h (P <0.05). 3. HE staining: histopathologic damages were alleviated with BRF administration, the inflammatory cell infiltration increased at 6h, peaked at 48h, and continued to 7d. 4. The expression of TNF-α: compared with normal saline group, the expression of TNF-α in BRF treatment group attenuated obviously at 48h and 72h (P <0.05). Conclusion The results suggest that BRF may produce neuroprotective effects against infarction damage by reducing brain edema and inhibiting the expression of TNF-α. Related Articles | Metrics

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Concept and Principle of Spectral Computed Tomography XUE Yun-Jing, DUAN Qing. Chinese Journal of Stroke    2013, 8 (02): 112-115.   Abstract （3680）      PDF （1683KB）（3245）       Knowledge map    Save The most prominent advantages of gemstone spectral computed tomography(CT) over conventional CT are its set of quantitative analysis and multi-parameter images, such as monochromatic images, spectral curve, material decomposition images and effective atomic number. Spectral CT provides not only an original tool for early diagnosis of diseases, quantitive evaluation and accurate diagnosis but also a novel platform for clinical and research. It is important for radiologists and clinicians to understand and be familiar with the concept and principle of spectral CT Reference | Related Articles | Metrics

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Long-term Outcome of Elective Stenting for Symptomatic IntracranialVertebrobasilar Stenosis XU Xiao-Tong;JIANG Wei-Jian;DU Bin;et al.    2008, 3 (11): 798-802.   Abstract （3655）      PDF （2033KB）（1089）       Knowledge map    Save Objective To examine long-term outcome of a largest case series to date after elective stenting of symptomatic atherosclerotic intracranial vertebrobasilar artery(VBA) stenosis.Methods During September 2001 till September 2007, elective stenting with a balloon-expandable stent was performed in 116 consecutive patients with atherosclerotic intracranial vertebrobasilarartery(VBA) stenosis ≥50% that resulted in qualifying stroke or TIA(Transient Ischemic Attack)event within 180 days.Results There were eight strokes within 30 days, and five strokes in the VBA territory after 30 days(mean of 1005 days). The annual stroke rate in the VBA territory (including any stroke and death within 30 days) was 4.0%Significantly higher stroke-free survivals in the vertebrobasilar territorywere found in stent success subgroup and VA stenosis patients.Conclusion Elective stenting can reduce the annual stroke risk and improve function outcome of patients with symptomatic atherosclerotic vertebrobasilar stenosis that compares favorably to medical therapy. The long-term outcome is associated with successful stent placement and stenotic site. Related Articles | Metrics

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Stratification Diagnosis and Treatment of Ischemic Cerebrovascular Disease-Professor Wang Yong-Jun‘s Lecture on the Second Training Project of Standard Management in Stroke Patients ZHENG Hua-Guang;SUN Hai-Xin;JIA Qian;WANG Chun-Juan;WANG Gui-Hong    2008, 3 (02): 85-91.   Abstract （3634）      PDF （2082KB）（227）       Knowledge map    Save Related Articles | Metrics

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Histopathological Change of Cerebral Ischemic Injury and the Interventional Effect of Salvianolic Acid B ZHAO Xu;FAN Ying-Chang;XU Xiu-Mei;et al.    2008, 3 (02): 109-113.   Abstract （3613）      PDF （2123KB）（207）       Knowledge map    Save Objective To investigate the histopathological change of brain tissue after focal cerebral ischemia reperfusion injury in rats and the neuroprotective effect of Sallvianolic acid B.Methods Thirty-two healthy male Wistar rats were randomly divided into 4 groups with 8 rats in each group: sham-operation group, model group, middle-dosage group and high-dosage group of salvianolic acid B. Distilled water was given to the fore two groups by intragastric administration route. Different Salvianolic acid B concentration, 96 mg/kg and 192 mg/kg ,was given to the latter groups by same way respectively. All groups were given once daily for 7 days. One hour after last infusion, middle cerebral artery occlusion(MCAO)was induced using intraluminal suture technique in the rats except the sham-operation group. After 2 h of ischemia and followed 24 h of reperfusion, the pathomorphological changes of brain tissue in all groups of rats were observed using hematoxylin and eosin(HE) staining method, and the ischemic area of brain tissue was detected using pathological image analytical technique and apoptotic index was detected using terminal uridine deoxynucleotidyl transferase nick end labeling(TUNEL) method.Results In model group,compared with sham-operation group, we could find that the focal ischemic regions, disordered tissue construction,interstitial substance edema,neuron degeneration and necrosis were severe in brain tissue of the injury side and apoptotic indexes were increased. In both Salvianolic acid B groups,compared with model group,disordered construction of ischemic regions, interstitial substance edema and the degree of neuron degeneration were relieved and necrosis cells were obviously decreased, the cerebral ischemic area was significantly decreased by 12% and 14% respectively(P<0.01), and apoptotic indexes were also significantly decreased by 16.0% and 17.3% respectively(P<0.01), but there was no dose-dependent relation.Conclusion .Salvianolic acid B has protective effect on histomorphology of brain tissue in rats with focal cerebral ischemia reperfusion injury. Related Articles | Metrics

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Eternal Shining Socrates WANG Yong-Jun Chinese Journal of Stroke    2015, 10 (11): 913-914.   Abstract （3605）      PDF （1846KB）（1163）       Knowledge map    Save Reference | Related Articles | Metrics

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2008, 3 (06): 430-437.   Abstract （3596）      PDF （2832KB）（1706）       Knowledge map    Save Related Articles | Metrics

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2008, 3 (06): 423-429.   Abstract （3544）      PDF （1465KB）（1303）       Knowledge map    Save Related Articles | Metrics

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Revised and Updated Recommendations for the Establishment of Primary Stroke Centers: a Summary Statement from the Brain Attack Coalition WANG Chun-Juan;WANG Yi-Long;LI Zi-Xiao;et al    2012, 7 (08): 646-657.   Abstract （3542）      PDF （2072KB）（975）       Knowledge map    Save Related Articles | Metrics

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Progress of Post-stroke Sleep Disorders BAI Ying, ZHANG Ning, WANG Chun-Xue. Chinese Journal of Stroke    2013, 8 (05): 407-411.   Abstract （3528）      PDF （1825KB）（1376）       Knowledge map    Save Post-stroke sleep disorders (PSSD) is a frequent post-stroke complication but lack of attention. Its occurrence is related to stroke itself including lesion location and neurobiochemical changes as well as sociopsychological factors. It has several clinical forms, and the diagnosis should be based on the relative diagnostic criteria and scales evaluation. The therapeutic strategy depends on specific clinical condition. Pharmacotherapy combined with non-pharmacotherapy is usually applied. This review mainly focuses on the clinical features, epidemiology data, related risk factors, diagnosis and therapy of PSSD in order to provide a reference for the clinical practice. Reference | Related Articles | Metrics

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Measurement of Cerebrovascular Reserve to Posterior Circulation with Gantry Angled Perfusion CT and CO 2 Test in Symptomic Vetebral-Basilar Artery Stenosis Patients LIU Ming-Yong;ZHOU Li-Chun;WANG Yong-Jun;et al    2008, 3 (05): 326-329.   Abstract （3526）      PDF （1953KB）（823）       Knowledge map    Save Objective To explore the feasibility of the cerebrovascular reserve assessment with gantry angled perfusion computed tomography(CT) and carbon dioxide(CO2) test in patients with posterior circulation hemodynamic impairment.Methods Perfusion CT with 5% CO2 and 95% oxygen(O2) was used to investigate 9 symptomic vertebral-basilar artery stenosis patients with posterior circulation hemodynamic impairment. CT gantry angle was selected from -13 degree to -23.5 degree (mean -14.7±1.7degree) for the purpose that base line paralleled to vertical line of the level. This protocol could avoid bone artifacts furthest.Results The cerebrovascular reserve of brainstem ranged from -19.83% to 53.36% and of cerebellum ranged from -20.58% to 45.50%.Conclusion It is safe and feasible to assess cerebrovascular reserve with gantry angled perfusion CT and CO2 test in patients with posterior circulation hemodynamic impairment. Related Articles | Metrics

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Effect of Low Molecular Weight Heparin on Transient Ischaemia Attack DONG Wei-Wei;DENG Fang;WANG Shou-Chun;et al.    2008, 3 (03): 0-180.   Abstract （3525）      PDF （1859KB）（1148）       Knowledge map    Save Objective To evaluate the effect of low molecular weight heparin (LMWH) on transient ischemic attack (TIA).Methods It was a prospective, non-random and control study. Total 102 patients suffered from first onset of TIA were included and divided into two groups: 48 cases in LMWH group and 54 cases in control group. Regulating blood pressure, reducing blood sugar, aspirin 50 mg and Ozagrel 160 mg, once per day were all done to all patients. Five thousand units of LMWH were given to patients in treatment group twice a day for 7 to 10 days. Common situations like age, sex, ischemic type(internal carotid artery system or vertebrobasilar artery system), lasting time, times of onset, risk factors had no significant difference between the two groups.Results The curative effect of TIA in the near future and prognosis after 30 days showed no significant difference between the two groups(p>0.05). There was no significant difference between the two groups in the rate of stroke(including TIA recurrence and cerebral infarction) and myocardial infarction after three months. Two patients had gingival bleeding in treatment group and no patient suffered from bleeding in control group.Conclusion Compared with control group, LMWH shows no superiority in therapy of TIA. Related Articles | Metrics

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Effects of BPI-1095 on Expression of Bcl-2 in Rats after Focal Cerebral Ischemia    2008, 3 (09): 654-657.   Abstract （3514）      PDF （2507KB）（889）       Knowledge map    Save Objective To investigate the effects of different doses of BPI-1095 on the area of infarction and Bcl-2 protein expression in middle cerebral artery occlusion (MCAO) rats, as well as to explore the protection effects of BPI-1095 on ischemic brain tissue after local cerebral ischemia and its mechanism.Methods Model rats of cerebral ischemia were randomly divided into six groups. Each rat has been given different dosage of medicine and was sacrificed 24 h after treatment. The brain was removed from the skull. Iimmunohistochemistry staining was used to identify Bcl-2 expression in ischemic brain tissue, and the brain tissue was stained by 2% triphenyl-tetrazolium chloride (TTC) to measure the percentage of infarct area.Results 1. The percentage of infarct area was significantly decreased in treated rats with high or moderate dosage compared with the control group (P <0.05); 2. The expression of Bcl-2 protein increased at the boundary and cortex zone of the infarct compared with contralateral hemisphere area.The percentage of positive cells was significantly increased in rats treated with high dosage compared with control or ASA-treated rats. 3. There were no significant differences among three groups of different dosages of BPI-1095.Conclusion BPI-1095 may has a protection effect on brain, especially with high (240 mg/kg) or moderate dosage (80 mg/kg). The mechanism is closely related with the increase of Bcl-2 protein expression. Related Articles | Metrics

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Clinical Features of Perimesencephalic Nonaneurysmal Subarachnoid Hemorrhage LIU Ai-Hua;LI You-Xiang;YANG Zhong-Hua;et al    2008, 3 (05): 311-314.   Abstract （3500）      PDF （1500KB）（803）       Knowledge map    Save Objective To investigate the clinical and radiological features and prognosis of perimesencephalic nonaneurysmal subarachnoid hemorrhage (PNSH).Methods Total 34 cases whose subarachnoid hemorrhage lesions were found only within perimesencephalic cisterns were retrospectively investigated, including the clinical data, radiological features, treatments and prognosis.Results All the patients were conscious, whose Hunt-Hess scale were Grade I to II and they were all cured, without serious cerebral vasospasms, hydrocephalus, or rebleeding.Conclusion It is important for correct analysis of PNSH to improve correct diagnosis and treatments. Related Articles | Metrics

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The Effects of Fluoxertin on the Brain-derived Neurotrophic Factor Levels in theHippocampus of the Animal Model of Post-stroke Depression    2008, 3 (09): 648-653.   Abstract （3498）      PDF （2665KB）（747）       Knowledge map    Save Objective To observe brain-derived neurotrophic factor levels in the hippocampus of the animal model of post-stroke depression.Methods The focal cerebral ischemia model was set up by blocking the middle cerebral artery(MCA), and then the model rats were separately raised and put into chronic unpredictable mild stress to induce the PSD model, part of them were intervened by fluoxertine. The rats were examined dynamically by Open-field test (OFT), sucrose consumption test. Western-blot and Real time-PCRwere used to detect BDNF protein and mRNA levels respectively.Results On the 14th day after CUMS, the PSD group showed significantly less locomotor activity and sugar-water consumption (P <0.05 or P <0.01) compared with the control group. On the 18th ,28th day, BDNF protein levels of the PSD group declined significantly (P <0.05 or P <0.01) compared with the control group. BDNF mRNA levels on the18th day were reduced, but there was no statisticdifference. While on the 28th day, BDNF mRNA levels significantly declined (P <0.01). On the 14th and 18th day, open-field activities and the amount of sugar-water consumption of the fluoxertin intervention group increased markedly (P <0.05 or P <0.01) compared with the PSD group, while onthe 18th and 28th day, BDNF protein and mRNA levels of the fluoxetine group were significantly increased (P <0.01) compared with the PSD group respectively.Conclusion Anhedonia and underactivity, the core symptoms of depression, exist persistently in the PSD group rats. Fluoxetine may can improve the behavior abnormality of the PSD rats. Brain derived neurotrophic factor levels in the animal model of post-stroke depression was significantlyreduced and fluoxetine can reverse its expression levels, BDNF may has neuroprotect effect in poststroke depression. Related Articles | Metrics

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Advance in Predicting Hemorrhage Transformation after Intravenous Thrombosis HUANG Qiang, WU Jian Chinese Journal of Stroke    2013, 8 (03): 190-196.   Abstract （3498）      PDF （2064KB）（2646）       Knowledge map    Save This article reviews the risk factors of complications of symptomatic intracerebral hemorrhage(SICH) after intravenous thrombolysis and its related predictive models and also compares the characteristics and clinical values of those models with the aim to facilitate obtaining the reliable therapy strategies for acute ischemic stroke and choosing the quantitative assisted instruments for those who required intravenous thrombolysis in clinical practice. Reference | Related Articles | Metrics

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Clinical Features of Moyamoya Disease in Adults    2008, 3 (07): 472-476.   Abstract （3480）      PDF （2358KB）（1356）       Knowledge map    Save Objective To explore the clinical features in adult patients with moyamoya disease. Methods The age of onset, gender and clinical features of 244 Chinese adult patients with moyamoya disease were analyzed and compared with the data of the patients with moyamoya disease in Korea, Japan and North America. Results In the 244 patients, the age was from 18 to 72 years old. The mean age was 36 years. The male and female ratio was 1:1.03, which 120 were females and 124 were males. The initial symptom was cerebral ischemia in 187 patients and cerebral hemorrhage in 57 patients. All the patients came from 28 different provinces. Patients from Henan and Hebei province were 34 and 30 cases, which the proportion was the most. All the patients had digital subtraction angiography (DSA)/ magnetic resonance angiography(MRA) examination, and according to Suzuki stage, the I to VI stage was in 24, 96, 112, 152, 80 and 24 hemispheres respectively. In our cases, 244 patients underwent encephaloduro- arterio-synangiosis (EDAS) operation. After the operation, 57 cases that the initial symptom was hemorrhage had no rebleeding, and 161 cases in 187 patients that the initial symptom was ischemia had relief obviously, 26 cases no marked change. Conclusion Adult patients in China with moyamoya disease present with different clinical features compared with other countries. These observations may indicate the various mechanisms involved in moyamoya disease in China. EDAS is an effective method for the adult patients with moyamoya disease. Related Articles | Metrics

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Analysis of Apolipoprotein E Gene Polymorphism in Patients with Cerebrovascular Disease JIANG Chang-Chun;SUN Hong-Ying;HE Ji-Ling;et al.    2008, 3 (03): 0-185.   Abstract （3413）      PDF （1993KB）（1239）       Knowledge map    Save Objective To study the apolipoprotein E gene(ApoE) polymorphism in patients with cerebrovascular disease(CVD).Methods The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique were used to detect ApoE genetype in 98 CVD patients(78 cerebral infarction and 20 cerebral hemorrhage) and 90 age-matched controls. We used enzyme chromatometry to detect the level of lipids.Results The frequency of genotype E3/4 was 23.1% and E4 was 14.7% in the cerebral infarction group, significantly higher than those in control group (P<0.05). The frequency of genotype E3/3 was 56.4% and E3 was 75.6% in the cerebral infarction group, which were significantly lower than in the control group(P<0.05). While in cerebral hemorrhage group the ApoE genotype and the frequency of allele had no significant difference when compared with control group(P>0.05). The serum levels of total cholesterol(TC) and low density lipoprotein-cholesterol(LDL-C) were significant difference in different ApoE genotype subgroups(P<0.05).Conclusion ApoE4 is one gene of cerebral infarction while ApoE3 has protection to cerebral infarction. The polymorphisms of apolipoprotein E gene have effect on the serum level of TC and LDL-C. Related Articles | Metrics

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Establishing and Evaluating a Rabbit Model with Carotid Stenosis of Various Degrees ZHENG Chong;WU Gang;RUAN Qin-Yun;et al.    2008, 3 (02): 98-103.   Abstract （3380）      PDF （3270KB）（125）       Knowledge map    Save Objective To establish a carotid stenosis model which is convenient for evaluating the hemodynamics of stenosis arteries.Methods By using suture, we bound the carotid arteries with plastic tubes in different calibers to establish the carotid stenosis model in various degrees, and then to evaluate the stenosis with digital subtraction angiography (DSA) and the hemodynamics with transcranial Doppler sonography (TCD).Results In the DSA results(CCA criterion), the light was 30%, the moderate 59%, the severe 84%; In TCD results, we could clearly detect the hemodynamics before and after establishing the models and the pulsatility index(PI) and resistance index(RI) both reduced after establishing the models except the proximal of the severe. But in all models we could find that in the proximal of stenosis the blood velocity reduced and the PI and RI increased; in the spot of stenosis, the blood velocity increased while the PI and RI reduced; in the distal of stenosis, the blood velocity, PI and RI also reduced.Conclusion Using our method we can establish a stenosis model quickly, stably and the hemodynamics are convenient to be detected. These models are more ideal to evaluate the hemodynamics in the carotid stenosis. Related Articles | Metrics

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Evaluation of Pyramidal Tract Injury in Acute Intracerebral Hemorrhage with MR Diffusion Tensor Tractography ZHOU Jian;WANG Wei;ZHANG Xin-Jiang;et al    2008, 3 (11): 819-823.   Abstract （3376）      PDF （2043KB）（826）       Knowledge map    Save Objective To evaluate the relationship between pyramidal tract injury in acute intracerebral hemorrhage assessed by MR diffusion tensor tractography(DTT) techniques and motor rehabilitation.Methods Diffusion tensor imaging was performed on 30 patients with basal ganglia or thalamus hemorrhage within 2 weeks after upsets, and the integrity of the pyramidal tracts was assessed by DTT. Motor function rehabilitation was assessed with Barthel Index(BI) after 6 months from upsets.BI scores of the different groups were compared and the correlation was analyzed between the integrity of the pyramidal tracts and the BI scores.Results 7 cases were eliminated because of unsatisfied data and 23 cases were enrolled. BI scores had significant difference among the groups divided by DTT findings of the pyramidal tracts integrity(F =9.693, P <0.01). There was significant correlation between the integrity of the pyramidaltracts in acute stage and the BI scores after 6 months(r =0.733, P <0.01).Conclusion The DTT findings for pyramidal tract in acute intracerebral hemorrhage may be used to predict the motor outcome. Related Articles | Metrics

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Clinical Analysis of Intravenous Thrombolysis Therapies in Acute Cerebral Infarction with Different Dosage of Reconstructive Tissue Plasminogen Activator(rt-PA)    2009, 4 (04): 289-292.   Abstract （3356）      PDF （2110KB）（1021）       Knowledge map    Save Objective FDA recomanded 0.9mg/kg IV rt-PA in thrombolysis treatment for acute ischemic stroke.The trials about IV rt-PA in china have chosen some different dose. To analyze the suitable dosage of rt-PA in Chinese we compared 0.9mg/kg IV rt-PA with 0.6-0.8mg/kg(50mg/person) IV rt-PA.Methods 30 patients were randomly assigned in our study. The NIHSS were from 2 to 26, the stroke onset time is 0.5 to 6 hours, without contraindications to thrombolytic therapy(China cerebrovasculardisease guide contraindication of thrombolysis). The patients were randomly divided into Group A and B, Group A with rt-PA 50mg/person, Group B with rt-PA 0.9mg/kg. To compare between two groups the number of patients with a decrease of 4 or more points on the National Institutes of HealthStroke Scale (NIHSS) at 24 hours and day 14. The intracerebral hemorrhage rate and mortality were also be compared.Results The two groups were well matched on baseline characteristics, including NIHSS (mean of 10.17for both). NIHSS improvement rate of group B at day 14 is signifcient better than group A (86.67% vs 53.3%, P <0.05).The intracerebral hemorrhage rate of two groups were both 6%. Themortality at 14 days in Group A were higher than Group B(26.67% vs 20%, P =0.67).Conclusion This study found significant benefit on 14 days in patients treated by 0.9mg/kg IV rt-PA than (0.6-0.8)mg/kg(50mg/person) IV rt-PA after stroke onset. Risk of intracerebral hemorrhage and mortality was not increased in 0.9mg/kg IV rt-PA. 0.9mg/kg IV rt-PA was suitable for Chinese inthrombolysis treatment for acute ischemic stroke. Related Articles | Metrics

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Effect of Fasting Blood Glucose on Cognitive Function in Patients with Asymptomatic Carotid Atherosclerotic Plaque: A Survey of Rural Residents ZHANG Qian, ZHANG Guanyi, ZHANG Jia, CHEN Shengyun, ZHAO Xingquan Chinese Journal of Stroke    2022, 17 (07): 753-757.   DOI: 10.3969/j.issn.1673-5765.2022.07.013 Abstract （3345）      PDF （1876KB）（62）       Knowledge map    Save Objective  To explore the effect of fasting blood glucose on cognitive function in patients with asymptomatic carotid atherosclerotic plaque. Methods  Participants aged ≥40 years who participated in the China National Stroke Screen Survey (CNSSS) program between September 2015 to September 2017, from two rural communities (Beiqijia community, Changping District, Beijing and Konggang community, Shunyi District, Beijing), were enrolled in this study. The included patients had carotid atherosclerotic plaques confirmed by carotid ultrasound, yet no cerebrovascular diseases and neurological deficits. Cognitive function was evaluated by the Montreal cognitive assessment (Beijing version). The multivariable logistic regression analysis was used to determine the association between fasting blood glucose and cognitive impairment (MoCA<26 points). Results  Finally, a total of 1446 subjects were included in this study, with a mean age of 62.0±8.3 years and 809 males (55.9%). 1364 (94.3%) had an education level of no more than 12 years, and 936 (64.7%) had cognitive impairment. Univariate logistic regression analysis showed that fasting blood glucose was associated with cognitive impairment (Ptrend=0.003). After adjusting for the confounding factors, fasting blood glucose was still an independent risk factor for cognitive impairment (Ptrend=0.008). The patients with the highest quartile of fasting blood glucose had an  increased risk of cognitive impairment by 0.49 times, compared to patients with the lowest quartile (OR 1.49, 95%CI 1.10-2.02, P=0.010). Conclusions  High fasting blood glucose was an independent risk factor for cognitive impairment in patients with asymptomatic carotid atherosclerotic plaque. Reference | Related Articles | Metrics