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    20 July 2016, Volume 11 Issue 07
    The Pursuit of Excellence
    WANG Yong-Jun
    2016, 11(07):  509-513. 
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    Standardization of Right-to-Left Shunt Detection sby Contrast-enhanced Transcranial Doppler
    GUO Yu-Zhu, XING Ying-Qi
    2016, 11(07):  515-529. 
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    Resting-state Functional Magnetic Resonance Imaging Study of Leukoaraiosis Patients with Cognitive Impairment
    SHEN Hui-Cong, CHANG Tian-Jing, ZHAN Jiong, et al.
    2016, 11(07):  530-535. 
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    Objective To investigate the differences in the resting state network between patients with cognitive impairment related leukoaraiosis and normal control. Methods A total of 40 patients with leukoaraiosis related cognitive impairment diagnosed by iconographic and clinical diagnosis and 30 normal controls were included in this study. The restingstate functional magnetic resonance imaging was scanned. All subjects of the two groups were matched in age, gender and level of education. The independent component analysis was used to deal with the data, and the two-sample t -test was used to compare the differences between the two groups. Results Compared with the normal control group, leukoaraiosis patients with cognitive impairment showed significantly decreased activation at bilateral precuneus, left inferior temporal gyrus, left fusiform gyrus and right anterior cingulate; increased activation at left paracentral lobule and right cuneus; significantly increased activation at left superior temporal gyrus; and significantly decreased activation at bilateral cuneus, middle occipital gyrus and left lingual gyrus. Conclusion There were many differences in resting-state functional brain network between patients with cognitive impairment related leukoaraiosis and normal control.

    Efficacy Analysis of Carotid Endarterectomy and Carotid Artery Stenting
    CHEN Yu, LIU Chang-Wei, LIU Zhi-Li, et al.
    2016, 11(07):  536-541. 
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    Objective To analyze the early and midterm outcomes of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in patients with arteriosclerotic carotid artery stenosis retrospectively. Methods The clinical data were collected and analyzed for the patients with arteriosclerotic carotid stenosis treated with CEA or CAS from January 2010 to December 2014 in Peking Union Medical College Hospital. The rate of periprocedural complication, the restenosis and ipsilateral stroke happened in the first year after the procedure were compared. Results From January 2010 to December 2014, 572 patients with carotid artery stenosis were treated in our institution. Among whom, 456 cases of CEA and 116 cases of CAS were performed. There was no significant difference of the characteristics in the two groups. There was no significant difference in surgery-related death (0.2% vs 0), 30 d ischemic stroke (1.1% vs 1.7%), acute myocardial infarction (0.7% vs 1.7%), wound hematoma (0.4% vs 0.8%), implant infection (0.4% vs 0), cranial nerve damage (1.1% vs 0) and hyperperfusion syndrome (5.7% vs 3.4%) between CEA and CAS, respectively. The ratio of persistent hypotension was significant higher in CAS group (12.9% vs 1.1%, P <0.01). One year follow-up showed that there was more restenosis (>50%) in CAS group (6.9% vs 2.6%, P =0.026), but there was no significant difference in severe restenosis (>70%) (2.5% vs 1.1%) and ipsilateral stroke (0.9% vs 0.4%) between the two groups. Conclusion Both CEA and CAS are safe and effective in the treatment of carotid artery stenosis. However, the ratio of persistent hypotension and restenosis is significant higher in CAS group.

    Risk Factor for Rehaemorrhagia after Hypertension Cerebral Hemorrhage Treatment by the Frontal Drainage Cone
    WANG Jing-Guang, LI Hai-Jun
    2016, 11(07):  542-546. 
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    Objective To investigate the risk factors for rehaemorrhagia after hypertension cerebral hemorrhage treatment by the frontal drainage cone, so as to provide clinical reference. Methods Retrospective analysis was used based on data of patients who had rehaemorrhagia after the frontal drainage cone treatment of hypertension cerebral hemorrhage from January 2013 to February 2015 in People′s Hospital of Qinglong. Patients' gender, age, preoperative blood pressure, blood glucose, blood lipid level, body mass index, preoperative hematoma volume, blood coagulation function, preoperative Glasgow Coma Scale (GCS) score, Montreal Cognitive Assessment (MoCA) scores, the United States National Institutes of Health Stroke Scale (NIHSS) scores, time between onset and operation, intraoperative bleeding were recorded. The multifactor and single factor Logistic regression analysis were used to analyze risk factors for rehaemorrhagia after frontal cone hole drainage treatment of hypertensive cerebral hemorrhage. Results A total of 100 cases were collected, including 15 cases of postoperative bleeding. The occurrence rate was 15.0%. The single factor analysis results showed that systolic blood pressure [(125±12) mmHg vs (146±17) mmHg, P <0.001], preoperative hematoma volume [(58.7±4.5) ml vs (63.4±6.2) ml, P <0.001], the time between onset to operation [5.1 (6.0) h vs 6.9 (6.2) h, P <0.001],

    intraoperative with active bleeding [11 (12.9%) vs 9 (60.0%), P <0.001], and postoperative blood pressure control rate [60 (70.6%) vs 3 (20.0%), P <0.001] between non-rehaemorrhagia group and rehaemorrhagia group had significant differences. Multifactor Logistic regression analysis showed that large preoperative hematoma volume [OR 1.035, 95%CI (1.008, 2.359)], long duration between onset and operation [OR 1.289, 95%CI (1.027, 6.325)], intraoperative active bleeding [OR 2.154, 95%CI (1.067, 3.245)] were risk factors for rehaemorrhagia after the frontal cone hole drainage treatment of hypertensive cerebral hemorrhage, and the postoperative blood pressure control [OR 0.147, 95%CI (0.004, 0.358)] was the protective factor. Conclusion Large hematoma volume, long duration between onset and operation, intraoperative with active bleeding, uncontrolled postoperative blood pressure are risk factors for patients underwent frontal drainage cone treatment of hypertension cerebral hemorrhage after the high incidence of bleeding.

    Obstruction of Venous Drainage Linked to Transient Global Amnesia
    HAN Ke, ZHAO Ya-Qin,ZHANG Feng-Ji, et al.
    2016, 11(07):  547-555. 
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    Abnormal extracranial venous drainage modality has been considered an etiology of transient global amnesia (TGA). Evidence suggests that the transmission of the intrathoracic/ intraabdominal pressure during a Valsalva maneuver (VM) is mainly through the vertebral venous system, and patency of internal jugular vein (IJV) is essential for venous drainage and pressure releasing. We hypothesize that obstruction of IJV venous drainage is a contributing factor in TGA pathogenesis. A magnetic resonance imaging (MRI) protocol was used in 45 TGA patients and 45 age- and sex-matched controls to assess the morphologies of IJV, brachiocephalic vein (BCV) and asymmetry of transverse sinus (TS). The IJV was divided into the upper- and middle-IJV segments. Compared to the controls, TGA patients had significantly higher rates of moderate and severe compression/stenosis at the bilateral upper-IJV segment (left: 37.8% vs 17.8%, P =0.0393; right: 57.8% vs 15.6%, P <0.0012), in left BCV (60% vs 8.9%, P <0.0004),

    and in TS hypoplasia (53.3% vs 31.1%, P =0.0405). The prevalence of at least one site of venous compression/stenosis in IJV or BCV was significantly higher in patients than in controls (91.1% vs 33.3%, P <0.0004). The diameter of the left TS in MRV, but not in T1 contrast imaging, was significantly smaller in TGA patients than in controls (0.31±0.21 vs 0.41±0.19, P =0.0290), which was compatible with downstream venous stenosis/obstruction. TGA patients have a higher prevalence of compression/stenosis of the bilateral IJV and the left BCV and TS hypoplasia, which is new evidence that supports the role of extracranial veins in TGA pathogenesis.

    Ultrasonographic Evaluation of Optic Nerve Sheath Diameter among Healthy Chinese Adults
    WANG Li-Juan, FENG Liang-Shu, YAO Yan, et al.
    2016, 11(07):  556-562. 
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    The aim of the work described here was to establish the range for optic nerve sheath diameter (ONSD) and potential factors influencing ONSD in healthy Chinese adults. Both ONSDs were measured twice in the sagittal and transversal planes by two observers. The final ONSD value for each participant was the average of 16 measurements of both eyes. The ONSD range (N =3680) among 230 participants was 2.65~4.30 mm. The upper ONSD limit was lower than those in previous studies in Caucasian and African samples. Simple linear regression analyses revealed that the ONSD was correlated with sex, body mass index and waistline and head circumference. After adjustment for potential confounds between these factors, sex (coefficient=0.225, P <0.001) and body mass index (coefficient=0.042, P <0.001) were independently associated with ONSD. Underweight women had the smallest ONSD. These results suggest that racial, sex, and body mass index differences should be noted when assessing ultrasonographic criteria.

    Optimal Optic Nerve Sheath Diameter Threshold for the Identification of Elevated Opening Pressure on Lumbar Puncture in a Chinese Population
    WANG Li-Juan, FENG Liang-Shu,YAO Yan, et al.
    2016, 11(07):  563-569. 
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    Ultrasonography of the optic nerve sheath diameter (ONSD) is a non-invasive and rapid method that might be helpful in the identification of increased intracranial pressure (ICP). The use of an ONSD greater than 5 mm on ultrasound as an indicator of increased ICP in a Caucasian population has been studied. However, the cut-off point of this predictor in Chinese patients has not been established. Thus, we conducted this study to identify the ONSD criterion for the detection of elevated opening pressure on lumbar puncture (LP) in a Chinese population and to investigate the influencing factors. This study was a blind cross-sectional study. Patients who presented with suspected increased ICP were included. The opening pressure on LP of each participant was confirmed. We analyzed the clinical differences between the groups of patients with abnormal and normal opening pressures on LP. A receiver operating characteristic curve was constructed to determine the ONSD cut-off point for the identification of abnormal opening pressure on LP. In total, 279 patients were recruited, and 101 patients presented with elevated opening pressure on LP. ONSD was a significant independent predictor of elevated opening pressure on LP (P <0.001). However, no statistical significance was observed regarding the factors that might have affected this relationship including gender, age, body mass index, waistline, head circumference, hypertension and pathological subtype. The ONSD cut-off point for the identification of elevated opening pressure on LP was 4.1 mm; this cut-off yielded a sensitivity of 95% and a specificity of 92%. ONSD is a strong and accurate predictor of elevated opening

    pressure on LP. The cut-off point of this predictor in a Chinese population was remarkably lower than that found in a Caucasian population. Thus, ethnic differences should be noted when using the ONSD as an indicator of increased ICP

    The Research Progress and the Clinical Significance of Ultrasonographic Optic Nerve Sheath Diameter for Assessing Intracranial Pressure
    WANG Li-Juan, CHEN Ying, XING Ying-Qi
    2016, 11(07):  571-575. 
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    Elevated intracranial pressure (ICP) can induce the nerve sheath to expand based on the ocular anatomy. Ultrasonography of the optic nerve sheath diameter (ONSD) is a non-invasive and bedside method that might be helpful in the identification of elevated ICP. The ONSD cutoff point for the diagnosis of increased ICP or elevated ICP has not been unified in domestic and international studies of the related fields. We propose that ethnic differences should be noted and appropriately applied to the corresponding ultrasonographic criteria. Ultrasound detection of ONSD bears a broad prospect of applications and researches.

    Comparison of Transcranial Doppler and Magnetic Resonance Angiography for Diagnosis of Severe Vertebrobasilar Artery Stenosis: a Case Report
    AN Li-Si, XING Ying-Qi, CHEN Pei-Min
    2016, 11(07):  576-579. 
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    The Diagnosis of Small Arteriovenous Malformation in the Distal Artery with Transcranial Doppler and Transcranial Color Doppler:a Case Report
    ZHANG Jie, GUO Zhen-Jie, WANG Li-Juan, et al.
    2016, 11(07):  580-584. 
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    A Case Report of Suspicious Arteriostenosis Diagnosed as Arteriovenous Malformation
    ZHANG Jie, GUO Zhen-Jie, CHEN Ying, et al.
    2016, 11(07):  585-588. 
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    Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke(Part 6)
    SHEN Dong-Chao, WANG Zi-Xuan, XIAO Fu-Long, et al.
    2016, 11(07):  589-593. 
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    Research Progress in Inherited Thrombophilia Associated with Cerebral Venous Sinus Thrombosis
    ZHENG Li-Qin, CHEN Jing-Jiong, ZHAO Yu-Wu
    2016, 11(07):  594-600. 
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    More than 20% of cerebral venous sinus thrombosis patients are companied with thrombophilia. The common genetic thrombophilia includes the lack of coagulation factors, antithrombin deficiency, abnormalities in fibrinolysis, hyperhomocysteinemia and the elevated level of coagulation factors. The article introduces the research status of inherited thrombophilia associated with cerebral venous sinus thrombosis

    Teaching Experience on Increasing the Diagnosability of Vascular Original White Matter  Lesions
    SHEN Hui-Cong, ZHAN Jiong, CHEN Hong-Yan, et al.
    2016, 11(07):  601-603. 
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    Objective To investigate the teaching method to increase the diagnosability of vascular original white matter lesions. Methods White matter lesions were teaching in both cerebrovascular diseases chapter and leukoencephalopathy chapter in imageology training to graduate students, residents and visiting physicians. The teaching effect was assessed after each class. Results All subjects passed the test after each class. The comprehensiveness of image reports was improved after learning of the leukoencephalopathy chapter. Conclusion The integration of cerebrovascular diseases chapter and leukoencephalopathy chapter is an effective teaching method in differential diagnosis of vascular original white matter lesions.

    Precise Medicine in Cerebral Vascular Disease: Education Practice and Exploration
    2016, 11(07):  604-606. 
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    Objective To describe the definition of precise medicine and its application status in the field of cerebral vascular disease and to evaluate the effectiveness of different education patterns in professional postgraduate teaching. Methods Observation and interview methods were used in this qualitative study during the course of clinical practice, research and education.The acquaintance on progress in thrombolysis, anticoagulation and antiplatelet therapy in acute ischemic stroke and the comprehension of the relationship between guideline and precise medicine were investigated, so as to evaluate the competence of application of precise medicine in guiding clinical practice. The optimal structure of knowledge and the efficient teaching approach were established with the experience from the western countries. Results The precise medicine consists of the precise imaging, big data and genomics and is used widely in clinical practice, research and development of new drugs. The precise medicine can also be helpful to set up the guideline and the health policy. The knowledge structure and the accomplishment of the medical students with a Master or Doctor degree still need to be improved. Clinical Epidemiology, Biostatistics, Molecular Biology and Computer Science are the foundation for the discipline of the precise medicine. To cultivate the competencies in the creating, clearing up and analyzing the database in project-based training program might be an effective education mode. Conclusion The precise medicine is the result of standardized healthcare development and the future of medical service. Medical students should build an inter-discipline knowledge background and get to be well-trained in the management of database in precise medicine project.

    Research on the Influence of Medical Reform Policies on the Cerebral Infarction Patients’ Hospital Cost
    2016, 11(07):  607-612. 
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    Objective To make an analysis of the differences in cerebral infarction patients’ hospital cost under different medical reform policies, so as to provide suggestions on making Beijing medical reform policy. Methods Based on relevant theories, the data of cerebral infarction patients’ hospital cost in Beijing Tiantan Hospital, Capital Medical University before and after three successive implementations of medical reform policies in terms of performance assessment, total prepaid amount and separation of Medicare and drug sale in 2012 were collected. The data from three aspects: tendency, necessity and accessibility were analyzed. Rank-sum test and multiple regression analysis in SPSS18.0 were conducted. The regression models were constructed. By using the regression models, the differences in hospital cost under different medical reform stages were compared. Results There was significant difference in the different medical reform stages. In the performance assessment stage, the cost of the patients with medical insurance reduced by11.44%, and that of self-pay patients by 6.91%. In the performance assessment plus total prepaid amount stage, the cost of the patients with medical insurance reduced by 9.51%, and that of self-pay patients increased by 2.88%. In the performance assessment plus total prepaid amount plus separation of Medicare and drug sale stage, the cost of the patients with medical insurance increased by 4.75%, and that of selfpay patients reduced by 25.50%. Conclusion The administrations of the medical reforms should pay attention to the different effects of medical reform on the cerebral infarction patients’ hospital cost, reinforce the supervision of medical organizations, guide reasonable medication, so as to reduce the disease burden of patients with cerebral infarctions.