Table of Content

20 February 2009, Volume 4 Issue 02

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主编手记

Practice Changed by the Conception

Wang Yongjun

2009, 4(02):  87-90. 

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述评

Attention to Blood Sugar Management, Improve the Treatment of Stroke

ZHANG Wei-Wei

2009, 4(02):  91-95. 

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论著

Study of the Relationship Between Blood-Pressrue Regulation and Angiotensin Receptors in Center and Periphery after Acute Intracerebral Hemorrhage in Spontaneously Hypertensive Rats

HOU Jun-Xia;WU Gang;ZHANG Sheng;et al.

2009, 4(02):  102-107. 

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Objective To study the relationship between ATR and blood-pressrue regulation. Methods A total of 30 six-month-old male SHR were used, The ICH model was established by infusing collagenase into rat caudate nucleus. Monitoring the change of blood pressure by tail-cuff. Immunohistochemistry and Reverse-Transcription Polymerase Chain Reaction(RT-PCR) were performed to detect the expression of ATR in center and periphery after ICH. Results (1) the blood pressure in SHR significantly increased after ICH at the first day(P<0.05), decreased at the third day and recovered from the seventh day to fourteenth day; (2) expression of AT1R in the brain up-regulated after ICH, especially at the third day(P<0.05), and then recovered from the seventh day to fourteenth day, (3) AT2R in the brain as well as AT1R and AT2R in the kidney no difference were found after ICH. Conclusion Blood pressure increased after ICH in SHR might be related with selectivity up-regulation AT1R in the brain.

Clinical and Neuroimaging Characteristics of Reversible Posterior Leukoencephalopathy Syndrome

ZHANG Zai-Qiang;Niu Song-Tao;JIAN Fan;et al.

2009, 4(02):  109-112. 

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To explore the pathomechanism of reversible posterior leukoencephalopathy syndrome by analyze its clinical and neuroimaging characteristics.Methods The clinical manifestation and neuroimaging findings of 6 cases of reversible posterior leukoencephalopathy syndrome were reported.Results The clinical manifestation of this series included headache, visual disturbances, epilepsy and altered mental functioning. The causes involved were mal-controlled hypertension, eclampsia, cyclosporine A, hyperaldosteronism and so on. The neuroimaging findings were T1-hypointense/T2-hyperintense, Flair-hyperintense lesions predominantly in posterior temple-parieto-occipital regions symmetrically or asymmetrically.However,the lesions in some cases were mainly in brainstem. DWI of the affected areas showed slightly increased values ,meanwhile, apparent diffusion coefficient (ADC) maps showed high values in that areas. The T2*-weighted gradient-echo MR image displayed marked microhemorrhages widespread throughout, predominantly in posterior circulation.Conclusion Reversible posterior leukoencephalopathy syndrome is associated with miscellaneous causes. Vasospasms, micro-infarctions, microhemorrhages and vasogenic edema mainly contribute to Pathogenetic courses.

The Effect of Urinary Kallidinogenase on acute progressive cerebral infarction

WEN De-shu;WU Zhi-Wu;LUO Ri-Xiang;et al.

2009, 4(02):  113-116. 

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Objective To investigate the effect of Urinary Kallidinogenase on acute progressive cerebral infarction.Methods 125 patients with acute progressive cerebral infarction were randomly divided into two groups: treatment group with Urinary Kallidinogenase (n=63) and control group (n=62). According to Chinese Guidelines for Prevention and Management Cerebrovascular Disease, two groups were treated with basic therapy, such as antiplatelet, neurologic protection, blood pressure control,nerve recovery and so on. On basis of control group, treatment group was administrated intravenous injection of Urinary Kallidinogenase 0.15PNAU per day for 7~14 days. The primary efficacy was evaluated by NIHSS(the National Institutes of Health stroke scale, NIHSS), ADL(Activities of daily living,ADL) and clinical effective.Results Our study showed that the scores in ADL and NIHSS in the treatment group was higher than those of control group, Urinary Kallidinogenase could significantly reduce neurological deficits and the effective rate was up to 90.48%, curative rate of recent period was 52.38% compared with control group.Conclusion Urinary Kallidinogenase is maybe effective and safe in the treatment of acute progressive cerebral infarction.

专题论坛

The Relationship between Hyperglycemia and Prognosis of Stroke

PAN Chang-Yu

2009, 4(02):  118-121. 

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Is Postprandial Hyperglycemia a Risk Factor for Stroke?

XU An-Ding;LIU Li-Bing;YANG Wan-Yong

2009, 4(02):  122-126. 

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The Principle of Medical Management on Blood Sugar in the Secondary StrokePrevention

WANG Hong-Li;FAN Dong-Sheng

2009, 4(02):  132-137. 

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Recognition and Management of Stress Hyperglycemia in the Acute Phase after Stroke

ZHONG Li-Yong

2009, 4(02):  138-142. 

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病例讨论

A Case of Colon Cancer Combined with Trousseau Syndrome

SUN Tai-Xin;WEN Miao

2009, 4(02):  143-146. 

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指南与规范

Summary of Antithrombotic and Thrombolytic Therapy for Ischemic Stroke: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)

SHI Jian-Quan;WANG Bian-Rong;XU Jun

2009, 4(02):  147-149. 

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ESO Guideline Committee Statement on revised guidelines for intravenous thrombolysis

QIN Hai-Qiang;DU Wan-Liang

2009, 4(02):  150-151. 

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综述

Vascular Endothelial Growth Factor and Cerebrovascular disease and Neurodegeneration

DONG Yi;DONG Qiang

2009, 4(02):  152-157. 

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As a mitogen of vascular endothelial cell, vascular endothelial growth factor, functions as an induction to differentiate stem cell into endothelial progenitor cells, characterizes as vascular effects, neurotrophic effects and neurogentic effects. Abnormal regulation of VEGF (vascular endothelial growth factor) expression has now been implicated in several neurodegenerative disorders to get involved in apoptosis, regeneration and genetic relationship of nerve cells. Increased release of VEGF may serve nerve system with hyperperfusion, stimulate the proliferation of neuronal precursors and promote neurogenesis. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for Cerebrovascular disease and neurodegenerative disorders.

Endothelial Progenitor Cells and Stroke

CHEN Li-Yun;Alex F. Chen;WANG Yong-Jun.

2009, 4(02):  159-162. 

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As a population of adult stem cells, endothelial progenitor cells (EPC) have been focused on by many researchers in these years. However, most of studies on EPCs are on cardiovascular disease instead of stroke. It was found that EPC could be a biomarker of cardiovascular risk and EPC transplantation or regulation of EPC mobilization may play a role in the therapy of stroke. In this review, we will summarize the developments of researches on EPC and stroke.

Diabetes Mellitus and Leukoaraiosis

QI Dong;ZHENG Hua-Guang;WANG Chun-Xue.

2009, 4(02):  163-166. 

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Diabetes Mellitus is one of independent risk factors of cerebrovascular diseases, and it is closely related with brain small vessel disease(SVD). Leukoaraiosis(LA) is considered to be one type of SVD. LA has distinctively changes in imaging and manifests as cognitive impairment prominently in clinic, which impacts the patients’ quality of life seriously. The article reviews the research progress on the relationship between Diabetes Mellitus and Leukoaraiosis, as well as the related cognitive impairment.

临床研究与临床试验

Research on Abnormal Glucose Regulation in Patients with Acute Stroke Across China-a National Multicenter Prospective Observational Study

ZHENG Hua-Guang;JIA Qian;WANG Chun-Xue;et al

2009, 4(02):  167-170. 

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A Conceptual Framework for Writing a High Quality Research Proposal

PENG Xiao-Xia;QIN Hai-Qiang

2009, 4(02):  171-175. 

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教学园地

Pay Attention to the Cultivation of Clinical Thinking Ability during vascular Neurology Teaching

ZHOU Li-Chun

2009, 4(02):  176-178. 

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