Table of Content

20 February 2008, Volume 3 Issue 02

Previous Issue    Next Issue

主编手记

Stroke：Advances in 2007

WANG Yong-Jun

2008, 3(02):  77-84. 

Asbtract ( )   PDF (2087KB) ( )  

Related Articles | Metrics

热点报道

Stratification Diagnosis and Treatment of Ischemic Cerebrovascular Disease-Professor Wang Yong-Jun‘s Lecture on the Second Training Project of Standard Management in Stroke Patients

ZHENG Hua-Guang;SUN Hai-Xin;JIA Qian;WANG Chun-Juan;WANG Gui-Hong

2008, 3(02):  85-91. 

Asbtract ( )   PDF (2082KB) ( )  

Related Articles | Metrics

述评

Pay Attention to the Hemodynamics Disorders of Functional Disease

GU Shen-Wei

2008, 3(02):  92-93. 

Asbtract ( )   PDF (1500KB) ( )  

Related Articles | Metrics

论著

Synergetic Effects of Neuro-vascular Factors in the Pathogenesis of Migraine

WANG Ye;GU Shen-Wei;YANG Shao-Ju;et al

2008, 3(02):  94-97. 

Asbtract ( )   PDF (2099KB) ( )  

Related Articles | Metrics

Objective To analyze the synergetic effects of neuro-vascular factors in the pathogenesis of migraine.Methods Total 131 patients fulfilling the inclusion criteria of migraine were included in the study. Transcranial Doppler(TCD) and sympathetic skin response(SSR) findings were analyzed for migraineurs. According to the result of TCD and SSR, the significance of the presence of cerebral blood flow velocity and abnormal sympathetic activity were statistically analyzed.Results Elevated cerebral blood flow velocity were found in 87 of 131 patients, significantly different from those patients with normal velocity(136±15 cm/s vs 89±8cm/s, P<0.01). According to the value of SSR, positive result in 78 migraineurs with abnormal blood flow velocity, while negative result in 12 patients of normal velocity, and there was significantly difference between them(59.54% vs 9.16%, P<0.01). There was a statistically significant correlation between peak velocity (Vp) of TCD and latency of SSR(r=0.463, P<0.01) among all migraineurs.Conclusion Migraine is a neurovascular coupling disorder where the cerebral hemodynamics is malfunctioning. TCD combining SSR can assess the change of intracranial hemodynamics, which seems to be effective and safe to study the pathogenesis in the patients with migraine.

Establishing and Evaluating a Rabbit Model with Carotid Stenosis of Various Degrees

ZHENG Chong;WU Gang;RUAN Qin-Yun;et al.

2008, 3(02):  98-103. 

Asbtract ( )   PDF (3270KB) ( )  

Related Articles | Metrics

Objective To establish a carotid stenosis model which is convenient for evaluating the hemodynamics of stenosis arteries.Methods By using suture, we bound the carotid arteries with plastic tubes in different calibers to establish the carotid stenosis model in various degrees, and then to evaluate the stenosis with digital subtraction angiography (DSA) and the hemodynamics with transcranial Doppler sonography (TCD).Results In the DSA results(CCA criterion), the light was 30%, the moderate 59%, the severe 84%; In TCD results, we could clearly detect the hemodynamics before and after establishing the models and the pulsatility index(PI) and resistance index(RI) both reduced after establishing the models except the proximal of the severe. But in all models we could find that in the proximal of stenosis the blood velocity reduced and the PI and RI increased; in the spot of stenosis, the blood velocity increased while the PI and RI reduced; in the distal of stenosis, the blood velocity, PI and RI also reduced.Conclusion Using our method we can establish a stenosis model quickly, stably and the hemodynamics are convenient to be detected. These models are more ideal to evaluate the hemodynamics in the carotid stenosis.

Effect of Mild Hypothermia on the Expression of IL-6 and ICAM-1 in Rats with Focal Cerebral Ischemia

FU Sheng-Qi;ZHANG Shu-Ling;FENG Lai-Hui;et al

2008, 3(02):  104-108. 

Asbtract ( )   PDF (2001KB) ( )  

Related Articles | Metrics

Objective To investigate the effect of mild hypothermia on the expression of ICAM-1 in the ischemia area and on the serum level of IL-6 concentration after middle cerebral artery occlusion (MCAO) in rats.Methods Thirty female Sprague-Dawley rats weighing 250-300 g were randomly assigned to the experiment group(n=15)and the control group(n=15). The unilateral MCAO models of rats were made by using suture embolism. After successfully making the MCAO models, the experiment group and the control group were treated by mild hypothermia and normothermia, respectively. For the experiment group, temperature was maintained at(33±1) after10 minutes, and for the contrl group, temperature was kept at(37±0.5). Twelve hours after cerebral ischemia, 4ml blood was drawn from left ventricles, then the brain was immediately and carefully extracted in each rat. Immunohistochemistry analysis was used to count the number of ICAM-1 positive microvessel in the ischemia area, and immunoradiometric assay(IRA) was used to analyze the serum level of IL-6. Results The number of ICAM-1 positive microvessel in the ischemia area of brain in the experiment group were significantly less than that in the control group (2.45±1.56)/HP vs (18.27±2.45)/HP, (P<0.01), but the serum IL-6 concentration and the neurological severity score in the control group are obviously higher than in the experiment group[(184±38)ng/L vs (124±41) ng/L, P<0.01, (2.13±0.35) vs (1.48±0.25), P<0.01, respectively].Conclusion Mild hypothermia can reduce the serum IL-6 concentration and the ICAM-1 expression in ischemia area after cerebral ischemia. We presume that decreasing the expression of IL-6 and ICAM-1 is one of the neuroprotective mechanism in treating ischemic stroke by using mild hypothermia.

Histopathological Change of Cerebral Ischemic Injury and the Interventional Effect of Salvianolic Acid B

ZHAO Xu;FAN Ying-Chang;XU Xiu-Mei;et al.

2008, 3(02):  109-113. 

Asbtract ( )   PDF (2123KB) ( )  

Related Articles | Metrics

Objective To investigate the histopathological change of brain tissue after focal cerebral ischemia reperfusion injury in rats and the neuroprotective effect of Sallvianolic acid B.Methods Thirty-two healthy male Wistar rats were randomly divided into 4 groups with 8 rats in each group: sham-operation group, model group, middle-dosage group and high-dosage group of salvianolic acid B. Distilled water was given to the fore two groups by intragastric administration route. Different Salvianolic acid B concentration, 96 mg/kg and 192 mg/kg ,was given to the latter groups by same way respectively. All groups were given once daily for 7 days. One hour after last infusion, middle cerebral artery occlusion(MCAO)was induced using intraluminal suture technique in the rats except the sham-operation group. After 2 h of ischemia and followed 24 h of reperfusion, the pathomorphological changes of brain tissue in all groups of rats were observed using hematoxylin and eosin(HE) staining method, and the ischemic area of brain tissue was detected using pathological image analytical technique and apoptotic index was detected using terminal uridine deoxynucleotidyl transferase nick end labeling(TUNEL) method.Results In model group,compared with sham-operation group, we could find that the focal ischemic regions, disordered tissue construction,interstitial substance edema,neuron degeneration and necrosis were severe in brain tissue of the injury side and apoptotic indexes were increased. In both Salvianolic acid B groups,compared with model group,disordered construction of ischemic regions, interstitial substance edema and the degree of neuron degeneration were relieved and necrosis cells were obviously decreased, the cerebral ischemic area was significantly decreased by 12% and 14% respectively(P<0.01), and apoptotic indexes were also significantly decreased by 16.0% and 17.3% respectively(P<0.01), but there was no dose-dependent relation.Conclusion .Salvianolic acid B has protective effect on histomorphology of brain tissue in rats with focal cerebral ischemia reperfusion injury.

编者按

Hemodynamics of Cerebrovascular Disease-Part II

WANG Gui-Hong

2008, 3(02):  114-114. 

Asbtract ( )   PDF (1506KB) ( )  

Related Articles | Metrics

专题论坛

CT Perfusion Imaging and Stages of Regional Cerebral Hypoperfusion in Preinfaction Period

Gao Pei-Yi

2008, 3(02):  115-119. 

Asbtract ( )   PDF (3511KB) ( )  

Related Articles | Metrics

The Value of Method in Microembolic Monitoring and Prognosis Assessment of Stroke

WANG Ye

2008, 3(02):  120-123. 

Asbtract ( )   PDF (1715KB) ( )  

Related Articles | Metrics

Clinical Application of TCD in Patients with Hemorrhagic Disease

WU Gang

2008, 3(02):  124-127. 

Asbtract ( )   PDF (2241KB) ( )  

Related Articles | Metrics

Sickle Cell Anemia and its Effects on Hemdynamics

LIU Huan-Hu;PAN Xu-Dong

2008, 3(02):  128-130. 

Asbtract ( )   PDF (1714KB) ( )  

Related Articles | Metrics

Sickle cell anemia is a autosomal dominant inheritance hemoglobin disease, caused by the replacement of Glu by Val in the 6th amino acid in beta chain of hemoglobin. Its clinical manifestations include chronic hemolytic anemia, infection, recurrence of pain crisis and histologic lesion caused by chronic ischemia. This article introduces the epidemiology, pathogenesy, clinical manifestation, diagnosis and treatment of sickle cell anemia, especially its hemodynamics effects. It provides a new way to the prevention and treatment of stroke for sickle cell anemia patients.

病例讨论

Thoracic Outlet Syndrome Diagnosed by TCD：A Case Report

GAO Feng-Ling;XU Zhong-Bao;LI Ji-Mei;et al

2008, 3(02):  133-135. 

Asbtract ( )   PDF (1969KB) ( )  

Related Articles | Metrics

指南与规范

Assessment：Transcranial Doppler ultrasonography：Report of the Therapeutics and Technology Assessment Subcomittee of the American Academy of Neurology

WANG Gui-Hong

2008, 3(02):  136-147. 

Asbtract ( )   PDF (2626KB) ( )  

Related Articles | Metrics

综述

Fabry's Disease and Stroke in Young People

SONG Zhe;BI Qi;WANG Li-Feng

2008, 3(02):  148-151. 

Asbtract ( )   PDF (1949KB) ( )  

Related Articles | Metrics

Fabry disease is a X-linked inherited recessive disorder. Partial or total deficiency of the enzyme α-galactosidase A caused by deficiency or mutation of gene at Xq22 leads to failure to catabolize cellular lipids. The progressive accumulation of its production such as globotriaosylceramide(Gb3)in a range of cells and tissues including renal, heart, vascular walls and nervous systems results in organ damage in many systems. Clinical manifestations concerning multi-systems maybe exist during young patients. The main manifestation of central nervous system is transient ischemic attacks or ischemic stroke. Fabry disease must be considered in all cases of unexplained stroke in young patients. Recent years, a new special therapy--enzyme replacement therapy has a good effect on this disease. The therapy should start at early stage but not after having organs damage. Earlier diagnosis and treatment can improve the prognosis and patients’ living quality.