新型冠状病毒导致脑血管疾病相关机制探讨

doi:10.3969/j.issn.1673-5765.2020.11.004

摘要/Abstract

摘要：

2019冠状病毒病（coronavirus disease 2019，COVID-19）已经成为人类社会迄今为止面临的最大挑战之一，具有传播广、重症及死亡率高的特点。现有研究发现COVID-19患者脑血管病发病率为 0.5%，发病机制以栓塞和大动脉粥样硬化为主，大血管病变似乎在COVID-19相关卒中患者中更常见。病毒与血管紧张素转化酶2受体的相互作用、炎症反应和凝血紊乱等在COVID-19相关卒中发病中可能发挥作用。因此本文对COVI D-19患者的脑血管病流行病学、临床特点和发病机制进行归纳总结，以期更好地指导临床诊疗。

文章导读： COVID-19患者脑血管病发病机制以栓塞和大动脉粥样硬化为主，病毒与血管紧张素转化酶2受体的相互作用、炎症反应和凝血紊乱等在COVID-19相关卒中发病中可能发挥作用。

关键词: 2019冠状病毒病; 严重急性呼吸综合征冠状病毒2; 脑血管病

Abstract:

Coronavirus disease 2019 (COVID-19) with a wide epidemic, high probability of deterioration and mortality, has become one of the biggest challenges for human society. It was reported that the prevalence of stroke in COVID-19 patients was 0.5%, with embolism and atherosclerosis as its main pathogenesis. There seemed to be more large-vessel stroke in COVID-19 patients. The interaction between the virus and ACE2 receptor, inflammation and coagulopathy played important roles in the pathogenesis of stroke in the COVID-19 patients. Therefore, this article aimed to summarize the relationship between severe acute respiratory syndrome coronavirus 2 and cerebrovascular diseases, to better guide the clinical diagnosis and treatment.

Key words: Coronavirus disease 2019; Severe acute respiratory syndrome coronavirus 2;Cerebrovascular disease

顾聪，吴雪纯，曹勇军，刘春风，张霞. 新型冠状病毒导致脑血管疾病相关机制探讨[J]. 中国卒中杂志, 2020, 15(11): 1168-1174.

GU Cong,WU Xue-Chun, CAO Yong-Jun, LIU Chun-Feng, ZHANG Xia. Study on the Mechanisms of Cerebrovascular Disease Caused by Coronavirus Disease 2019[J]. Chinese Journal of Stroke, 2020, 15(11): 1168-1174.

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