中国卒中杂志 ›› 2023, Vol. 18 ›› Issue (11): 1315-1323.DOI: 10.3969/j.issn.1673-5765.2023.11.015
孔德敏1,邹伟2
收稿日期:
2023-02-20
出版日期:
2023-11-20
发布日期:
2023-11-20
通讯作者:
邹伟 kuangzou1965@163.com
KONG Demin1, ZOU Wei2
Received:
2023-02-20
Online:
2023-11-20
Published:
2023-11-20
摘要: 脑出血是一种由脑实质血管破裂引起的严重疾病,目前尚无有效的治疗方法。研究表明炎症反应在脑出血继发性脑损伤中发挥了重要作用。在出血部位,小胶质细胞被迅速招募并激活,且在促炎型与抑炎型之间动态转变,不同的信号通路可以改变小胶质细胞极化的状态,从而对脑损伤起到调控作用,这提示了小胶质细胞在脑出血继发脑损伤的病理过程中具有复杂的作用机制。促炎型小胶质细胞释放的各种炎症因子介导神经细胞和神经组织的炎症损伤;抑炎型小胶质细胞释放趋化因子、脑源性神经营养因子、抗炎介质等诱导小胶质细胞向病变方向迁移,吞噬有害分子和细胞碎片,减轻炎症损伤,促进炎症消退、组织修复及神经再生。然而,目前对于小胶质细胞极化在脑出血后的动态变化及机制尚未完全阐明,故对参与脑出血小胶质细胞极化的相关调控分子以及信号通路的研究已引起了广泛关注,有望成为脑出血治疗的潜在靶点。
孔德敏, 邹伟. 脑出血后小胶质细胞极化及其相关炎症信号通路对继发性脑损伤的影响[J]. 中国卒中杂志, 2023, 18(11): 1315-1323.
KONG Demin, ZOU Wei. Impact of Microglia Polarization and Related Inflammatory Signaling Pathways on Secondary Brain Injury after Intracerebral Hemorrhage[J]. Chinese Journal of Stroke, 2023, 18(11): 1315-1323.
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