中国卒中杂志 ›› 2024, Vol. 19 ›› Issue (10): 1205-1214.DOI: 10.3969/j.issn.1673-5765.2024.10.014

• 综述 • 上一篇    下一篇

脑出血后神经炎症与脑铁代谢的相关性研究进展

鞠佳俊,王心心,杭黎华   

  1. 苏州 215300 南京医科大学姑苏学院,昆山市第一人民医院麻醉科
  • 收稿日期:2023-12-18 出版日期:2024-10-20 发布日期:2024-10-20
  • 通讯作者: 杭黎华 zjhanglihua@foxmail.com
  • 基金资助:
    江苏省卫生健康委科研项目(M2021072)
    昆山市高层次医学人才项目(Ksgccrc2004)
    昆山市第一人民医院科技兴卫工程(CXTD21-C05;KRY-YN2007)

Research Progress on the Correlation between Neuroinflammation and Brain Iron Metabolism after Intracerebral Hemorrhage

JU Jiajun, WANG Xinxin, HANG Lihua   

  1. Gusu School, Nanjing Medical University, Department of Anesthesiology, The First People’s Hospital of Kunshan, Suzhou 215300, China
  • Received:2023-12-18 Online:2024-10-20 Published:2024-10-20
  • Contact: HANG Lihua, E-mail: zjhanglihua@foxmail.com

摘要: 脑出血是指脑实质内非外伤性血管破裂引起的出血,是一种严重的神经系统疾病。其主要病理生理特点包括大量出血和神经元死亡,可损害神经免疫系统,严重影响患者的预后。铁离子稳态对维持神经系统的正常功能至关重要,然而脑出血发生后的铁代谢紊乱会导致脑内铁积聚。过量的铁通过激活炎症信号通路、调节炎症细胞功能等途径参与神经炎症反应,而神经炎症细胞也调节铁离子的运输和储存,两者相互作用共同加重神经损伤。本文综述了脑出血后神经炎症与脑铁代谢的相关研究进展,旨在为脑出血的临床治疗提供参考。

文章导读: 本文深入探讨了脑出血后神经炎症细胞与脑铁积聚之间的紧密联系,两者相互作用加重继发性损伤,为临床治疗提供了新思路。

关键词: 脑出血; 铁; 铁代谢; 神经炎症

Abstract: Intracerebral hemorrhage refers to bleeding caused by non-traumatic rupturing of blood vessels within the brain, which is a serious neurological disorder. Its main pathophysiological characteristics include massive bleeding and neuron death, which impair the neuroimmune system and severely affect the patient’s prognosis. Iron ion homeostasis is crucial for maintaining normal neurological function. However, following intracerebral hemorrhage, disrupted iron metabolism leads to iron accumulation in the brain. Excessive iron participates in neuroinflammatory responses by activating inflammatory signaling pathways and regulating the function of inflammatory cells, while neuroinflammatory cells also participate in regulating the transportation and storage of iron ions. The interaction between the two exacerbates neurol damage. This article reviews the progress of research on the correlation between neuroinflammation and brain iron metabolism after intracerebral hemorrhage, aiming to provide a reference for the clinical treatment of intracerebral hemorrhage.

Key words: Intracerebral hemorrhage; Iron; Iron metabolism; Neuroinflammation

中图分类号: