远端缺血预适应在脑梗死中的脑保护机制及临床应用研究进展

doi:10.3969/j.issn.1673-5765.2024.01.014

摘要/Abstract

摘要： 脑梗死是全球范围内致残率和致死率较高的疾病之一，大量研究表明，远端缺血预适应（remote ischemic preconditioning，RIPC）能够显著提高靶器官对缺血的耐受程度，减小梗死面积，改善患者预后，但目前对其在脑梗死发生发展中的作用机制研究较少。本文将从神经、体液和免疫3个方面，结合相关信号通路对RIPC在脑梗死中的作用及作用机制进行总结，并综述RIPC目前在临床缺血性脑疾病中的应用进展，以期为后续研究提供参考依据。

文章导读： 本文综述了远端缺血预适应在脑组织缺血性疾病损伤中的作用及可能机制，为脑梗死的治疗提供了重要参考依据。

关键词: 脑梗死; 远端缺血预适应; 脑保护; 信号转导

Abstract: Cerebral infarction is one of the diseases with high rates of disability and death worldwide, but there is still a lack of more effective treatments. Many studies showed that remote ischemic preconditioning (RIPC) can significantly improve ischemic tolerance of target organs, reduce infarct size and improve prognosis. However, its role and mechanism in the development of cerebral infarction are still little studied. This paper will summarize the role and mechanism of RIPC in cerebral infarction from the following aspects: neural, humoral, immune and related signaling pathways, and review the current research progress of RIPC in clinical cerebral ischemic diseases to provide a reference for subsequent research.

Key words: Cerebral infarction; Remote ischemic preconditioning; Cerebral protection; Signal transduction

中图分类号:

刘旭东, 刘萌, 苏颖, 周艳霞, 任力杰. 远端缺血预适应在脑梗死中的脑保护机制及临床应用研究进展[J]. 中国卒中杂志, 2024, 19(1): 105-111.

LIU Xudong, LIU Meng, SU Ying, ZHOU Yanxia, REN Lijie. Current Research in the Mechanism and Clinical Application about Remote Ischemic Preconditioning in Cerebral Infarction[J]. Chinese Journal of Stroke, 2024, 19(1): 105-111.

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