关键词: 狭窄; 病理性; 症状和体征; 危险因素

Abstract: Objective To investigate the clinical manifestations, characteristics, and risk factors of intra-andextra-cranial elongation and stenosis.Methods Two thousand two hundred and eighteen patients aged 45 to 89 years old were enrolledto perform aortocranial angiography. Arterial abnormality were classified as arterial elongation andstenosis based on the DSA images. The clinical manifestation was categorized as dizziness, TIAand cerebral infarction, while the risk factors included advanced age, primary hypertension anddiabetes mellitus. Distribution of arterial elongation and stenosis and their clinical manifestationswere compared using Chi-Square test, and multiple risk factors of intra-and extra-cranial elongationand stenosis were analysed by Logistic regression analysis.Results Arterial elongation and stenosis were observed in 1816 patients from 2218 patients,occurence of arterial elongation and stenosis was 76.1% or 23.9% separately. For patients withS- or O-typed elongation in internal carotid arteries, occurence of cerebral infarction was 40.0%or 47.9%. For patients with S- or O-typed elongation in vertebro-basilar arteris, the occurenceof TIA was 57.6% or 25.0%. For severe stenosis in internal carotid artery, occurence of TIA andcerebral infarction was 45.3% or 35.8%. For moderate and severe stenosis in vertebro-basilar artery,occurence of TIA was 48.6% or 48.4% separately. In addition, age (OR=3.28, 95% CI 2.16-4.75),BMI (OR =2.95, 95% CI 2.02-4.31), primary hypertension (OR =3.17, 95% CI 2.12-4.69) anddiabetes mellitus (OR =2.82, 95% CI 1.96-3.87) were related to the occurence of intra-and extracranialelongation and stenosis.Conclusion The arterial elongation and stenosis severity exhibited a significant correlation to theclinical manifestation. And age, BMI, primary hypertension and diabetes were risk factors of theintra-and extra-cranial elongation and stenosi

Key words: Constriction; pathologic; Symptoms & signs; Risk factors