关键词: 脱髓鞘疾病; 磁共振成像; 对比研究

Abstract: Objective To compare the shear stiffness between ischemic demyelination and normal white matterby using Magnetic Resonance Elastography (MRE).Methods Patients group: 14 consecutive patients with ischemic demyelination at the grade ofFazekas scale II or above defined by routine MR sequences scan in 2009 were involved. Controlgroup: 16 human volunteers in 2009 were enrolled. All the subjects underwent head MRE. Afterpostprocessing raw images by computer, shear modulus of ischemic demyelination area withinsemioval centre in patients group and normal semioval centre in control group were seperativelymessured. We used independent-sample T test to analyze the difference between ischemicdemyelination and normal white matter.Results All the shear modulus of research areas in two groups were successfully obtained, with theresult of right side(8.7±3.0)kPa, and left side(10.9±2.5)kPa in patients group, while right side(16.6±4.5)kPa, and left side(16.4±3.7)kPa in control group, which were significant different.Conclusion The shear stiffness of ischemic demyelination was significantly lower than that ofnormal white matter.

Key words: Demyelinating diseases; Magnetic resonance imaging; Comparative study