关键词: 螺杆菌; 幽门; 脑梗死; 危险因素; 病例对照研究

Abstract: Objective The aim of our study was to investigate the association between helicobacter pylori (Hp)infection and ischemic stroke Subtypes.Methods Total of 123 patients with ischemic stroke were enrolled. Analyses were stratifiedfor etiologic stroke subtypes according to 2007 modified TOAST criteria: 94 patients withatherothrombosis (AT), 14 patients with cardioembolism (CE), 12 patients with small arterydisease (SAD). 131 control subjects without clinical and instrumental evidence of atherosclerosisdiseases were randomly selected from clinic. All subjects were recorded potential risk factorsfor Hp infection and traditional risk factors for IS. The serumal specific antibody IgG of Hp wasdetected by enzyme-linked immunosorbent assay (ELISA). Conditional logistic regression wasused.Results Hp-IgG-positive rate of patient group was higher, but the difference was not statisticallysignificant (69.1% vs 61.8%, OR =1.381, P =0.223). This result remained no significant afteradjusting for potential risk factors for Hp infection and known risk factors for IS (OR 1.284,95%CI 0.705-2.338, P =0.413). Subgroup analyses yielded similar results in all etiologic strokesubtypes (univariate analysis: AT: OR 1.455, 95%CI 0.827-2.561, P =0.193; CE: OR 1.111, 95%CI0.352-3.504, P =0.857; SAD: OR 1.852, 95%CI 0.478-7.167, P =0.366; Multivariate analysis: AT:OR 1.441, 95%CI 0.726-2.861, P =0.297; CE: OR 0.894, 95%CI 0.249-3.211, P =0.864; SAD: OR1.836, 95%CI 0.396-8.503, P =0.437).Conclusion Our case-control study does not provide evidence of any strong association betweenHp chronic infection and IS. There is still need for large case-control and mainly prospective studies to investigate the contribution of Hp infection to IS risk particularly subgroups.

Key words: Helicobacter pylori; Brain infarction; Risk factors; Case-control studies