关键词: 脑梗死; 脑白质疏松症; 危险因素

Abstract: Objective To evaluate the situation and risk factors of cerebral white matter lesions in ischemic stroke patients to decrease the prevalence.Methods Four hundred and eighty-three consecutive inpatients from Aug. 2007 to Oct. 2008 with acute ischemic stroke were enrolled into our study that was divided into two groups (with and without white matter lesions). Incidence and risk factors of white matter lesions were evaluated. Logistic regressions were applied to analyze related independent influencing factors.Results Of all the 483 patients, white matter lesions presented in 58.3%, the prevalence and severity of white matter lesions increasing with age(P<0.01). Logistic regression analysis indentified advanced age(OR=1.03, 95%CI 1.00-1.05, P<0.05), history of hypertension(OR=1.77, 95%CI 1.07-2.91, P<0.05), history of stroke(OR=1.71, 95%CI 1.02-2.88, P<0.05), the level of glucose(OR=1.07, 95%CI 1.00-1.15, P<0.05) and lacunar infarction(OR=1.89, 95%CI 1.17-3.06, P<0.05) as being significantly and independently associated with presence of white matter lesions.Conclusion The prevalence and severity of white matter lesions increasing with age. The presence of white matter lesions is significantly associated with age, history of hypertention and stroke, the level of glucose and lacunar infarction.

Key words: Brain infarction; Leukoariosis; Risk factors