关键词: 脑内微出血; 梯度回波磁共振; 缺血性卒中

Abstract: Objective To investigate the frequency and location of cerebral microbleeds(CMBs) in patientswith ischemic stroke, to compare the incidences among subtypes, and to analyze the correlationfactors and the correlation with the number of lacunar infarcts and the severity of white matterchanges(WMC).Methods Two hundred and sixty-one patients with ischemic stroke were recruited consecutively.The included patients were classified into 3 subtypes consist of cardioembolism, large arteryatherosclerosis and small artery occlusion(SAO) according to pathogenesis. The data of the clinicalcharacter and laboratory examination were recorded. The incidence and number of CMBs werestudied on magnetic resonance imaging(MRI), the number of lacunar infarction and severity ofWMC were also evaluated.Results Eighty(30.70%) patients were found with CMBs, the number from 1 to 109 whichdistributed at different parts of brain including cortical-subcortical area(46.09%), basalganglia(27.80%). The incidences(53.30%) of SAO was the highest among the subtypes. Logisticregression analysis indicated that hypertension, the number of lacunar infarction and severity ofwhite matter changes may served as the independent risk factors for CMBs. There was correlationbetween the number of CMBs and the number of lacunar infarction or severity of white matterchanges.Conclusion It shows a high frequency of CMBs in patients with ischemic stroke especially in theSAO. CMBs are associated with the number of lacunar infarcts(r =0.519, P <0.001) and severity ofwhite matter changes(r =0.437, P <0.001), which indicated CMBs may be an indicator of advancedsmall artery disease of brain, and the result should be taken into consideration when they are beingtreated.

Key words: Cerebral microbleed; Gradient-echo magnetic resonance imaging; Ischemic stroke