Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group[J]. N Engl J Med, 1995, 333:1581-1587.

 Hacke W, Kaste M, Bluhmki E, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke[J]. N Engl J Med, 2008, 359:1317-1329.

 IST-3 collaborative group, Sandercock P, Wardlaw JM, et al. The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 hours of acute ischaemic stroke(the Third International Stroke Trial[IST-3]):a randomised controlled trial[J]. Lancet, 2012, 379:2352-2363.

 Zinkstok SM, Roos YB, ARTIS investigators. Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke:a randomised controlled trial[J]. Lancet, 2012, 380:731-737.

 Nogueira RG, Lutsep HL, Gupta R, et al. Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke(TREVO2):a randomised trial[J]. Lancet, 2012, 380:1231-1240.

 Saver JL, Jahan R, Levy EI, et al. Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke(SWIFT):a randomised, parallel-group, non-inferiority trial[J]. Lancet, 2012, 380:1241-1249.

 Lansberg MG, Straka M, Kemp S, et al. MRI profile and response to endovascular reperfusion after stroke(DEFUSE2):a prospective cohort study[J]. Lancet Neurol, 2012, 11:860-867.

 SPS3 Investigators, Benavente OR, Hart RG, et al. Effects of clopidogrel added to aspirin in patients with recent lacunar stroke[J]. N Engl J Med, 2012, 367:817-825.

 Depta JP, Fowler J, Novak E, et al. Clinical outcomes using a platelet function-guided approach for secondary prevention in patients with ischemic stroke or transient ischemic attack[J]. Stroke, 2012, 43:2376-2381.

 Aguilar MI, Hart RG, Kase CS, et al. Treatment of warfarin-associated intracerebral hemorrhage:literature review and expert opinion[J]. Mayo Clin Proc, 2007, 82:82-92.

 Flibotte JJ, Hagan N, O'Donnell J, et al. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage[J]. Neurology, 2004, 63:1059-1063.

 Leissinger CA, Blatt PM, Hoots WK, et al. Role of prothrombin complex concentrates in reversing warfarin anticoagulation:a review of the literature[J]. Am J Hematol, 2008, 83:137-143.

 Dowlatshahi D, Butcher KS, Asdaghi N, et al. Poor prognosis in warfarin-associated intracranial hemorrhage despite anticoagulation reversal[J]. Stroke, 2012, 43:1812-1817.

 Traylor M, Farrall M, Holliday EG, et al. Genetic risk factors for ischaemic stroke and its subtypes(the METASTROKE collaboration):a meta-analysis of genome-wide association studies[J]. Lancet Neurol, 2012, 11:951-962.

 Holliday EG, Maguire JM, Evans TJ, et al. Common variants at 6p21.1 are associated with large artery atherosclerotic stroke[J]. Nat Genet, 2012, 44:1147-1151.

 International Stroke Genetics Consortium(ISGC), Wellcome Trust Case Control Consortium 2(WTCCC2), Bellenguez C, et al. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke[J]. Nat Genet, 2012, 44:328-333.

 Cook DJ, Teves L, Tymianski M. Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain[J]. Nature, 2012, 483:213-217.

 Keith D, El-Husseini A. Excitation Control:Balancing PSD-95 Function at the Synapse(EB/OL). (2008-03-28)[2012-01-05]. http://www.frontiersin.org/molecular_neuroscience/10.3389/neuro.02.004.2008/full

 VITATOPS Trial Study B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke(VITATOPS) trial:a randomised, double-blind, parallel, placebo-controlled trial[J]. Lancet Neurol, 2010, 9:855-865.

 Hankey GJ, Eikelboom JW, Yi Q, et al. Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack:a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial[J]. Lancet Neurol, 2012, 11:512-520.

 O'Donnell MJ, Fang J, D'Uva C, et al. The PLAN Score:A bedside prediction rule for death and severe disability following acute ischemic stroke[J]. Arch Intern Med, 2012, 15:1-9.

 Ntaios G, Faouzi M, Ferrari J, et al. An integer-based score to predict functional outcome in acute ischemic stroke:the ASTRAL score[J]. Neurology, 2012, 78:1916-1922.