中国卒中杂志 ›› 2014, Vol. 9 ›› Issue (05): 440-444.

• 综述 • 上一篇    下一篇

颈动脉粥样硬化斑块与新生血管的相关性研究进展

段婉莹1,王拥军2   

  1. 1100028 北京
    煤炭总医院神经内科
    2首都医科大学附属北京
    天坛医院神经内科
  • 收稿日期:2013-11-05 出版日期:2014-05-20 发布日期:2014-05-20
  • 通讯作者: 王拥军 y o n g j u nwa n g 1 9 6 2@ gmail.com

Relation of Carotid Atherosclerotic Plaque and Neovascularization

  1. *Department of Neurology, Meitan General Hospital, Beijing 100028,
    China
  • Received:2013-11-05 Online:2014-05-20 Published:2014-05-20

摘要:

缺血性卒中最常见的病因是动脉粥样硬化,颈动脉粥样硬化斑块的破裂可导致卒中事件 的发生。斑块内的复杂结构特征与斑块的易损性相关。斑块内新生血管是斑块发展和不稳定性增加 的危险因素之一。因此,正确认识斑块内新生血管的病因和发病机制,以及与斑块稳定性之间的关 系,有利于早期发现颈动脉粥样硬化并正确评估其稳定程度及破裂风险,对于预防和治疗卒中具有 重要意义。

文章导读: 本文阐述了动脉粥样硬化病变与斑块内新生血管间可能存在的相关性,简要介绍了近年来评估斑
块内血管的技术新进展,有利于及时识别颈动脉粥样硬化性病变的早期形成及发展变化。

关键词: 动脉粥样硬化; 颈动脉粥样硬化斑块; 新生血管

Abstract:

The most common cause of ischemic stroke is atherosclerosis, the rupture of carotid atherosclerotic plaque is responsible for most clinical symptoms of stroke. Evidence has shown the correlation between compositional features and plaque vulnerability. Observational studies identify neovascularization as a risk factor in atherosclerotic plaque growth and destabilization. Therefore, the correct understanding of the etiology and pathogenesis of neovascularization could lead to a more accurate plaque vulnerability assessment, the therapy of neovascularization is significant for the treatment and prevention of stroke.

Key words: Atherosclerosis; Carotid atherosclerotic plaque; Neovascularization