新型冠状病毒感染的中枢神经系统并发症

doi:10.3969/j.issn.1673-5765.2020.11.005

摘要/Abstract

摘要：

新型冠状病毒是一种继严重急性呼吸综合征病毒、中东呼吸综合征病毒之后出现并造成大流行的冠状病毒，主要侵犯呼吸系统，但由于其受体分布广泛，也会可以感染其他系统，包括中枢神经系统。新型冠状病毒可以通过直接侵犯、激活炎症反应、诱发自身免疫反应等机制影响中枢神经系统，并导致脑炎、急性脊髓炎、脑病、脑血管疾病、癫痫等一系列并发症，严重影响患者预后。本文将结合国内外现有文献，对上述并发症进行综合阐述，以供临床同道借鉴参考。【关键词】新型冠状病毒；中枢神经系统；并发症

文章导读： SARS-CoV-2可以通过直接入侵中枢神经系统、过度激活炎症反应、诱发自身免疫反应等机制影响中枢神经系统并造成一系列症状和并发症，这些并发症常有较高的致残率和死亡率，需要临床医师提高警惕并及时干预，以改善患者预后。

关键词: 新型冠状病毒; 中枢神经系统; 并发症

Abstract:

Coronavirus disease 2019, following severe acute respiratory syndrome virus and Middle East respiratory syndrome virus, is another coronavirus that caused a global pandemic. It mainly affects the respiratory system, but can also involve multiple systems including the central nervous system due to the wide distribution of receptors of the virus. The mechanisms of this virus involving central nervous system included direct invasion, activating inflammatory response and inducing autoimmune response, leading to a series of complications like encephalitis, acute myelitis, encephalopathy, epilepsy, and cerebrovascular disease, which seriously affected the prognosis of patients. This review summarized the above complications according to the literatures lately, to provide the reference for clinical practice.

Key words: Coronavirus disease 2019; Central nervous system; Complication

康志明，聂创，吴祥波，梅斌. 新型冠状病毒感染的中枢神经系统并发症[J]. 中国卒中杂志, 2020, 15(11): 1175-1182.

KANG Zhi-Ming, NIE Chuang, WU Xiang-Bo, MEI Bin. Central Nervous System Complications in Patients with Coronavirus Disease 2019[J]. Chinese Journal of Stroke, 2020, 15(11): 1175-1182.

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