1 Joshipura KJ, Ascherio A, Manson JE, et al. Fruit

and vegetable intake in relation to risk of ischemic

stroke[J]. JAMA, 1999, 282:1233-1239.

2 Sun AY, Simonyi A, Sun GY. The "French Paradox"

and beyond:neuroprotective effects of polyphenols[J].

Free Radic Biol Med, 2002, 32:314-318.

3 Bravo L. Polyphenols:chemistry, dietary sources,

metabolism, and nutritional significance[J]. Nutr Rev,

1998, 56:317-333.

4 Xu e R. Te a p oly phe nol s may a t t e nu a t e t he

neurocognitive impairment caused by global cerebral

ischemia/reperfusion injury via anti-apoptosis[EB/

OL] . (2 014 -11-2 0) [2 015 - 01-15 ] . h t t p: //www.

maneyonline.com/doi/abs/10.1179/1476830514Y.0000

000160?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.

org&rfr_dat=cr_pub%3dpubmed.

5 Sato Y, Nakatsuka H, Watanabe T, et al. Possible

contribution of green tea drinking habits to the

prevention of stroke[J]. Tohoku J Exp Med, 1989,

157:337-343.

6 Wu KJ, Hsieh MT, Wu CR, et al. Green tea extract

amelior ates lea r ning and memor y def icit s in

ischemic rats via its active component polyphenol

epigallocatechin-3-gallate by modulation of oxidative

st ress and neuroinf lammation[J ]. Evid Based

Complement Alternat Med, 2012, 2012:163106.

7 Hong JT, Ryu SR, Kim HJ, et al. Neuroprotective

effect of green tea extract in experimental ischemiareperfusion

brain injury[J]. Brain Res Bull, 2000,

53:743-749.

8 Panickar KS, Polansky MM, Anderson RA. Green tea

polyphenols attenuate glial swelling and mitochondrial

dysfunction following oxygen-glucose deprivation in

cultures[J]. Nutr Neurosci, 2009, 12:105-113.

9 Shah ZA, Li RC, Ahmad AS, et al. The f lavanol

(-)-epicatechin prevents stroke damage through the

Nrf2/HO1 pathway[J]. J Cereb Blood Flow Metab,

2010, 30:1951-1961.

10 Sutherland BA, Shaw OM, Clarkson AN, et al.

Neuroprotective effects of (-)-epigallocatechin

gallate following hypoxia-ischemia-induced brain

damage:novel mechanisms of action[J]. FASEB J,

2005, 19:258-260.

11 Pa rk JW, Hong JS, Le e KS, et al. Gre en t e a

polyphenol (-)-epigallocatechin gallate reduces matrix

metalloproteinase-9 activity following transient focal

cerebral ischemia[J]. J Nutr Biochem, 2010, 21:1038-

1044.

12 R a h ma n RM, Na i r SM, He l p s S C , e t a l .

(-)-Epigallocatechin gallate as an intervention for the

acute treatment of cerebral ischemia[J]. Neurosci Lett,

2005, 382:227-230.

13 Girbovan C, Morin L, Plamondon H. Repeated

resveratrol administration confers lasting protection

against neuronal damage but induces dose-related

alterations of behavioral impairments after global

ischemia[J]. Behav Pharmacol, 2012, 23:1-13.

14 Li Z, Pang L, Fang F, et al. Resveratrol attenuates

brain damage in a rat model of focal cerebral ischemia

via up-regulation of hippocampal Bcl-2[J]. Brain Res,

2012, 1450:116-124.

15 Wang Q, Xu J, Rottinghaus GE, et al. Resveratrol

protects against global cerebral ischemic injury in

gerbils[J]. Brain Res, 2002, 958:439-447.

16 Inoue H, Jiang XF, Katayama T, et al. Brain protection

by resveratrol and fenofibrate against stroke requires

peroxisome proliferator-activated receptor alpha in

mice[J]. Neurosci Lett, 2003, 352:203-206.

17 Feng Y, Liu YM, Leblanc MH, et al. Grape seed

extract given three hours after injury suppresses lipid

peroxidation and reduces hypoxic-ischemic brain

injury in neonatal rats[J]. Pediatr Res, 2007, 61:295-

300.

18 Ritz MF, Ratajczak P, Curin Y, et al. Chronic

treatment with red wine polyphenol compounds

mediates neuroprotection in a rat model of ischemic

cerebral stroke[J]. J Nutr, 2008, 138:519-525.

19 Hwang IK, Yoo KY, Kim DS, et al. Neuroprotective

effects of grape seed extract on neuronal injury by inhibiting DNA damage in the gerbil hippocampus

after transient forebrain ischemia[J]. Life Sci, 2004,

75:1989-2001.

20 Jin G, He XR, Chen LP. The protective effect of ginko

bilboa leaves injection on the brain dopamine in the

rat model of cerebral ischemia/reperfusion injury[J].

Afr Health Sci, 2014, 14:725-728.

21 Unal I, Gursoy-Ozdemir Y, Bolay H, et al. Chronic

daily administration of selegiline and EGb 761

increases brain's resistance to ischemia in mice[J].

Brain Res, 2001, 917:174-181.

22 Ahlemeyer B, Kr ieglstein J. Pharmacological

studies supporting the therapeutic use of Ginkgo

b i l o b a e x t r a c t fo r Al z h e ime r ' s d i s e a s e [ J ] .

Pharmacopsychiatry, 2003, 36 Suppl 1:S8-S14.

23 A h l eme y e r B, J u n k e r V, Hu h n e R , e t a l .

Neuroprotective effects of NV-31, a bilobalidederived

compound:evidence for an antioxidative

mechanism[J]. Brain Res, 2001, 890:338-342.

24 C a l a p a i G, Cr u p i A, Fi r e n z u o l i F, e t a l .

Neuroprotective effects of Ginkgo biloba extract in

brain ischemia are mediated by inhibition of nitric

oxide synthesis[J]. Life Sci, 2000, 67:2673-2683.

25 Ghoneim AI, Abdel-Naim AB, Khalifa AE, et al.

Protective effects of curcumin against ischaemia/

reperfusion insult in rat forebrain[J]. Pharmacol Res,

2002, 46:273-279.

26 Sun Y, Dai M, Wang Y, et al. Neuroprotection and

sensorimotor functional improvement by curcumin

af t e r int r a ce rebr al hemor rhage in mice[J ]. J

Neurotrauma, 2011, 28:2513-2521.

27 Pu F, Mishima K, Egashira N, et al. Protective effect

of buckwheat polyphenols against long-lasting

impairment of spatial memory associated with

hippocampal neuronal damage in rats subjected to

repeated cerebral ischemia[J]. J Pharmacol Sci, 2004,

94:393-402.

28 Lapi D, Vagnani S, Pignataro G, et al. Protective

effects of quercetin on rat pial microvascular changes

during transient bilateral common carotid artery

occlusion and reperfusion[J]. Front Physiol, 2012, 3:32.

29 Ahmad A, Khan MM, Hoda MN, et al. Quercetin

protects against oxidative stress associated damages

in a rat model of transient focal cerebral ischemia and

reperfusion[J]. Neurochem Res, 2011, 36:1360-1371.

30 Chen YC, Shen SC, Chen LG, et al. Wogonin, baicalin,

and baicalein inhibition of inducible nitric oxide

synthase and cyclooxygenase-2 gene expressions

induced by nitric oxide synthase inhibitors and

lipopolysaccharide[J]. Biochem Pharmacol, 2001,

61:1417-1427.

31 Chi YS, Cheon BS, Kim HP. Effect of wogonin,

a plant f lavone f rom Scutellaria radix, on the

suppression of cyclooxygenase-2 and the induction of

inducible nitric oxide synthase in lipopolysaccharidetreated

RAW 264.7 cells[J]. Biochem Pharmacol, 2001,

61:1195-1203.

32 Cho J, Lee HK. Wogonin inhibits ischemic brain

injury in a rat model of permanent middle cerebral

artery occlusion[J]. Biol Pharm Bull, 2004, 27:1561-

1564.

33 Castello-Ruiz M, Torregrosa G, Burguete MC, et

al. Soy-derived phytoestrogens as preventive and

acute neuroprotectors in experimental ischemic

stroke:influence of rat strain[J]. Phytomedicine, 2011,

18:513-515.

34 Qian Y, Guan T, Huang M, et al. Neuroprotection

by the soy isof lavone, genistein, via inhibition of

mitochondria-dependent apoptosis pathways and

reactive oxygen induced-NF-kappa B activation in a

cerebral ischemia mouse model[J]. Neurochem Int,

2012, 60:759-767.

35 Kindy MS. Inhibition of tyrosine phosphorylation

prevents delayed neuronal death following cerebral

ischemia[J]. J Cereb Blood Flow Metab, 1993, 13:372-377.

36 Lee B, Choi Y, Kim H, et al. Protective effects of

methanol extract of Acori graminei rhizoma and

Uncariae Ramulus et Uncus on ischemia-induced

neuronal death and cognitive impairments in the rat[J].

Life Sci, 2003, 74:435-450.

37 Sweeney MI, Kalt W, MacKinnon SL, et al. Feeding

rats diets enriched in lowbush blueberries for six

weeks decreases ischemia-induced brain damage[J].

Nutr Neurosci, 2002, 5:427-431.

38 Wen TC, Yoshimura H, Matsuda S, et al. Ginseng

root prevents learning disability and neuronal loss

in gerbils with 5-minute forebrain ischemia[J]. Acta

Neuropathol, 1996, 91:15-22.

39 Lim JH, Wen TC, Matsuda S, et al. Protection of

ischemic hippocampal neurons by ginsenoside Rb1,

a main ingredient of ginseng root[J]. Neurosci Res,

1997, 28:191-200.

40 Ke L, Guo W, Xu J, et al. Ginsenoside Rb1 attenuates

activated microglia-induced neuronal damage[J].

Neural Regen Res, 2014, 9:252-259.

41 Shen L, Zhang J. Ginsenoside Rg1 increases ischemiainduced

cell proliferation and survival in the dentate

gyrus of adult gerbils[J]. Neurosci Lett, 2003, 344:1-4.