关键词: 脑梗死; 房间隔缺损; 超声心动描记术; 经食管; 复发

Abstract: Objective To observe the effect of percutaneous closure of patent foramen ovale (PFO) or aspirintreatment to ischemic cerebrovascular diseases recurrence of patients with PFO.Methods The resident patients whose age≤55 years with cerebral infarction or transient ischemicattack (TIA) in the department of neurology of XuanWu hospital were selected continuously.All patients were diagnosed by transesophageal echocardiography(TEE). Finally, 45 patientswith PFO were researched. One group treated by aspirin were 38 persons, the other treated bypercutaneous PFO closure were 7. The recurrence rate of ischemic cerebrovascular diseases oftwo groups were compared.Results The size of PFO was not significant difference between two groups(P =0.461). After 3months and 6 months treatment, the group of percutaneous PFO closure had no recurrence, therecurrence rate of the group treated by aspirin were 7.89% and 13.12%, respectively. There wasno significant difference between two groups(P =0.595, 0.411). After 6 months, there were 5recurrences in the aspirin group, including 3 patients with small PFO(PFO≤1.9mm), but there wasno recurrence in the group closure.Conclusion The difference of recurrence rate between percutaneous PFO closure and aspirinwas not clear. But after percutaneous PFO closure, there was no recurrence. There was greatsignificance of percutaneous PFO closure for treating the patients with small PFO.

Key words: Brain infarction; Heart septal defects; atrial; Echocardiography; transesophageal; Recurrence