关键词: 颅内动脉狭窄; 急性缺血性卒中; 危险因素; 血管造影; 磁共振血管成像; 经颅多普勒超声（TCD）

Abstract: Objective To investigate the risk factors of symptomatic intracranial stenosis.Methods Total 136 consecutive patients with acute ischemic stroke were enrolled during Aprilto December in 2006 at Tiantan hospital. All stenosis vessels were found by digital subtractionangiography (DSA) or transcranial Doppler (TCD) and magnetic resonance angiography (MRA)examination. Of the 136 patients, 63(46%) were found to have the evidence of intracranial medianstenosis (defined as case group), 73(54%) patients had no obvious stenosis(defined as controlgroup). Risk factors of cerebrovascular disease were comparatively investigated between the 2groups. The variables included the demographic characteristics, past medical history, such ashypertension, diabetes, lipid disorders, homocysteine, ischemic cardiac disease, atrial fibrillation,smoking, alcohol drinking, prolonged sitting lifestyle and body mass index (BMI).Results Univariate analysis showed that there were significant differences between 2 groupsin hypertension, lipid disorders, ischemic cardiac disease and smoking. Multivariable logisticstepwise regression analysis found the hypertension (OR=2.631, 95%CI 1.124-6.160, P =0.026)and lipid disorders(OR=2.255, 95%CI 1.060-4.797, P =0.035) were independent risk factors ofsymptomatic intracranial stenosis with acute ischemic stroke.Conclusion The study suggests that hypertension, lipid disorders may be independent risk factorsof sympotomatic intracranial stenosis, and we need large cohort studies to confirm it.

Key words: Intracranial stenosis; Acute ischemic stroke; Risk factor; Digital subtractionangiography(DSA); Transcranial Doppler(TCD); Magnetic resonance angiography (MRA)