关键词: 颈动脉狭窄; 普罗布考; 心脑血管病

Abstract: Objective To investigat the effects of Prubucal on the soft plaque in the carotid atheroscleroticplaque.Methods One hundred and twenty patients were randomly divided into the treatment group andthe control group, 60 cases in each group.The patients in control group were treated with routinetherapy, whereas patients in treatment group with routine therapy were treated by routine therapyplus prubucal 500 mg bid/day for a course of six months. After six months color Doppler ultrasoundwas performed to examine the plaques’ characteristics, sizes and number, meanwhile blood glucoseand blood lipids were detected and the incidence of adverse events were recorded.Results (1) There was no significant difference in terms of age, sex and size the plaque betweenthe two groups (P >0.05). (2) There was a statistically significant difference in the decrease ofvolume and numbers of soft plaque between two groups (P <0.05). (3) After 6 months treatmentthe incidence of cerebrovascular diseases and cardiovascular diseases in treatment group wassignificantly reduced,as compared to that in control group. This indicated that there was asignificant difference between two groups (P <0.05).Conclusion Prubucal can intervene effectively the development of the soft plaque in thecarotid atherosclerotic plaque,and reduce the incidence of cerebrovascular diseases andcardiovasculardiseases.

Key words: Carotid stenosis; Tongxinluocapsule; Cerebrovascular diseases