Chinese Journal of Stroke ›› 2017, Vol. 12 ›› Issue (05): 457-461.DOI: 10.3969/j.issn.1673-5765.2017.05.018

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Advances in Relation between Folic Acid and Ischemic Stroke

  

  • Received:2016-09-16 Online:2017-05-20 Published:2017-05-20

叶酸与缺血性卒中关系的研究进展

黄欢,赵钢   

  1. 710032 西安第四军医大学西京医院神经内科
  • 通讯作者: 赵钢zhaogang@fmmu.edu.cn

Abstract:

Ischemic stroke has been the leading cause of death in Chinese population. Hyperhomocysteinemia is one of the independent risk factors of ischemic stroke, and supplementing folic acid can reduce plasma homocysteine level. To provide reference and new ideas for stroke prevention, we made a review of the effect of folic acid on ischemic stroke in primary and secondary prevention, affecting factors and how to supplement folic acid in this article.

目前补充叶酸在降低同型半胱氨酸、卒中预防方面的研究结果尚存在争议,但叶酸作为一种经济、安全的药物,其在卒中预防方面的价值值得更多的研究探索。

Key words: Ischemic stroke; Folic acid; Homocysteine; Methylenetetrahydrofolate reductase; Stroke prevention

摘要:

缺血性卒中是我国人口的首位死亡原因,高同型半胱氨酸血症是缺血性卒中的独立危险因素之一,补充叶酸能降低血浆同型半胱氨酸水平。本文就叶酸对缺血性卒中的一级预防和二级预防的作用、影响因素及补充叶酸的建议等研究进行综述,为卒中的预防提供新的治疗方法与思路。

关键词: 缺血性卒中; 叶酸; 同型半胱氨酸; 亚甲基四氢叶酸还原酶; 卒中预防