Abstract:

Objective To explore the relationship of serum interleukin-33 (IL-33) and carotid atherosclerosis plaque vulnerability. Methods According the result of carotid artery ultrasound, patients with ischemic stroke were divided to vulnerable plaque group, stable plaques group and non-plaque group. The clinical data were compared among groups. Logistic dichotomy regression analysis was used to analyze the influential factors for plaque stability of carotid arthrosclerosis. Pearson correlation analysis was used to analyze the correlation between serum IL-33 and related factors. Results A total of 133 patients with ischemic stroke were enrolled into study, among which, there were 52 cases of vulnerable plaque, 45 cases of stable plaques and 36 cases of non-plaque. There were significant difference in age, 2 h plasma glucose (2 h PG), hemoglobin A1c (HbA1c), intimamedia thickness (IMT) and level of serum IL-33. The age, 2 h PG, HbA1c, IMT of non-plaque group were lower than that of vulnerable plaque group and stable plaques group, and the serum IL-33 of non-plaque group was higher than that of vulnerable plaque group and stable plaques group. Logistic regression analysis result showed that relatively higher age, 2 h PG, HbA1c, IMT and relatively lower IL-33 were independent risk factors for carotid atherosclerosis vulnerable plaque. Pearson correlation analysis result showed that, serum IL-33 level negatively correlated with IMT (r =-0.336, P =0.000), and had no correlation with age, 2 h PG and HbA1C. Conclusion Serum IL-33 can effectively response the carotid atherosclerosis plaque instability, is a reliable serological index for clinical prediction of vulnerable plaques.

Key words: Serum interleukin-33; Atherosclerosis; Vulnerable plaque; Ischemic stroke; Risk factors

摘要：

目的 探讨血清白介素-33（interleukin-33，IL-33）与颈动脉粥样硬化斑块易损性的关系。 方法 将缺血性卒中患者按颈动脉超声检查结果分为易损斑块组、稳定斑块组及无斑块组。对比 各组临床资料。Logistic二分类回归分析颈动脉粥样硬化斑块是否稳定的影响因素。Pearson相关分析 血清IL-33与相关因素的相关性。 结果 研究共入组缺血性卒中患者133例，其中易损斑块组52例，稳定斑块组45例，无斑块组36例。 三组年龄、餐后2 h血糖（2 h plasma glucose，2 h PG）、糖化血红蛋白（hemoglobin A1c，HbA1c）、颈动脉 内膜中层厚度（i nti ma-media thickness，IMT）、血清IL-33水平比较差异有显著性。无斑块组年龄、2 h PG、HbA1c、IMT显著低于稳定斑块和易损斑块组，而血清IL-33显著高于后两组；易损斑块组IMT显著 高于稳定斑块组，血清IL-33显著低于稳定斑块组。Logistic回归分析显示，较高的年龄、2 h PG、HbA1c、 IMT以及较低的IL-33为缺血性卒中患者颈动脉粥样硬化斑块易损的危险因素。Pearson相关分析结果显 示，血清I L-33水平与I MT呈负相关（r =-0.336，P＜0.001），与年龄、2 h PG、HbA1C无相关性。 结论 血清IL-33水平可反映缺血性卒中患者颈动脉粥样硬化斑块的不稳定性，可以作为临床预测颈 动脉易损斑块的血清学指标。

关键词: 血清白介素-33; 动脉粥样硬化; 易损斑块; 缺血性卒中; 危险因素