The Value of Multimodal CT in Assessing Blood-brain Barrier and Collateral Circulation in Patients with Acute Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2017.08.009

Abstract

Abstract:

The importance of multimodal computed tomography (CT) scans for patients with acute ischemic stroke has been paid more and more attention by clinicians. In the acute phase of cerebral ischemia, CT scan can be used to identify cerebral hemorrhage or other brain disease. CT angiography can be used to evaluate the location of infarction and collateral circulation. CT perfusion imaging can provide clinicians with pathophysiological information in hyperacute cerebral ischemic. Measurement of parenchymal perfusion at the capillary level can be used to characterize tissue viability. Further, CT perfusion is useful for the detection of blood brain barrier disturbances with the permeability surface (PS) area product parameter. In the process of clinical diagnosis and treatment, the information provided by Multimodal CT could be used for comprehensive assessment of hemorrhagic transformation and clinical prognosis for patients with acute ischemic stroke.

Key words: Multimodal CT; CT angiography; CT perfusion; Blood-brain barrier; Collateral circulation

摘要：

多模式计算机断层扫描（computed tomography，CT）对急性缺血性卒中患者的重要性逐渐引起临床医生的重视，在脑缺血超急性期，CT平扫可对脑出血或其他脑部疾病进行鉴别，CT血管造影可评估血管梗死部位和侧支循环状态，CT灌注成像可以通过毛细血管的实际灌注情况来评估脑组织的活力，并通过计算血脑屏障的表面通透性（permeability surface，PS）判断血脑屏障的完整性，进一步指导临床医生溶栓及血管性治疗方案的制定，也可以预测卒中后患者发生出血转化的风险。临床诊疗过程中，结合多模式CT提供的信息，可对急性缺血性卒中患者出现出血转化和临床预后进行全面评估。

关键词: 多模式计算机断层扫描; CT血管造影; CT灌注成像; 血脑屏障; 侧支循环

张佳慧，徐运. 多模式CT对卒中患者血脑屏障完整性和侧支循环的评估价值[J]. 中国卒中杂志, 2017, 12(08): 702-705.

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