Progress of Role of Progranulin in Nervous System Diseases

doi:10.3969/j.issn.1673-5765.2019.07.016

Abstract

Abstract:

Progranulin (PGRN) is a multifunctional secretory glycoprotein. The abnormality in PGRN expression and related genes are closely related to nervous system inflammatory lesions, degenerative diseases, neurodegenerative diseases, brain cell lysosome homeostasis and bloodbrain barrier integrity, and PGRN is involved in various pathological processes in such diseases. This article reviewed the biological effects of PGRN and progress in the role of PGRN in some neurological diseases, to provide ideas and theoretical basis for research and treatment in some neurological diseases.

Key words: Progranulin; Neurological disease; Cerebral infarction; Blood-brain barrier;Inflammation

摘要：

颗粒蛋白前体（progranulin，PGRN）是一种多功能的分泌型糖蛋白。其表达水平及相关基因的异常改变与神经系统炎性病变、退行性病变、变性疾病、脑中溶酶体的稳态及血脑屏障完整性密切相关，参与到多种神经系统疾病的病理过程。本文对PGRN的生物学作用及其与相关神经系统疾病的研究进展进行综述，以期为相关患者的干预及相关疾病的研究提供思路及理论依据。

关键词: 颗粒蛋白前体; 神经系统疾病; 脑梗死; 血脑屏障; 炎症

ZHANG Qing, ZHANG Bei, LI Ya-Jun. Progress of Role of Progranulin in Nervous System Diseases[J]. Chinese Journal of Stroke, 2019, 14(07): 733-739.

张青，张蓓，李亚军. 颗粒蛋白前体在神经系统疾病中的研究进展[J]. 中国卒中杂志, 2019, 14(07): 733-739.

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