Abstract:

Objective To investigate correlation between postprandial hyperglycemia and lower extremity venous blood flow mechanics in patients with ischemic stroke. Methods According to the results of 2-h plasma glucose in the oral glucose tolerance test (2hPG), 162 inpatients with anterior circulation light stroke were selected. They were divided into experimental group with postprandial hyperglycemia (n =90), and control group with normal blood glucose (n =72). After admission, color Doppler ultrasonography was used to examine the morphology and structure of the deep veins of the lower extremities in two groups, and the venous diameter and peak flow velocity of the lower extremities were measured. The biochemical indexes of the two groups were measured by automatic biochemical analyzer. Results There was no significant difference between the two groups in sex, age, smoking, alcohol consumption, hypertension, national institute of health stroke scale (NIHSS) score, body mass index (BMI), total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C) levels. The 2hPG level in experimental group was higher than normal group (P <0.05). The diameters of common iliac vein, iliac vein, femoral vein, popliteal vein in experimental group was greater than that of the control group (P <0.05). The peak velocity of common iliac vein, iliac vein, femoral vein, popliteal vein in experimental group was lower than control group (P <0.05), which had significant difference. Conclusion In patients with ischemic stroke accompanied by postprandial hyperglycemia, the blood flow velocity of the lower limb vein became slower and the diameter of the vein increased accordingly, which might increase the risk of venous thrombosis in the lower extremities and was unfavorable to the prognosis of the patients.

Key words: Ischemic stroke; Postprandial hyperglycemia; Lower extremity venous;Hemodynamics

摘要：

目的 探讨缺血性卒中患者餐后高血糖与下肢静脉血流动力学的相关性。 方法 筛选前循环轻度缺血性卒中住院患者，根据口服葡萄糖耐量试验（oral glucose tolerance test， OGTT）中2 h血糖水平（2-h plasma glucose，2hPG）将餐后高血糖患者设为实验组（90例），血糖正常患 者设为对照组（72例）。采用彩色多普勒超声检查两组患者下肢深静脉的形态、结构，测量下肢静脉 管径及峰值流速，采用全自动生化分析仪测定两组生化指标。 结果 两组患者性别、年龄、吸烟、饮酒、高血压、美国国立卫生研究院卒中量表评分（National Institutes of Health Stroke Scale，NIHSS）、体质指数（body mass index，BMI）、总胆固醇（total cholesterol， TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（low density lipoprotein-cholesterol，LDL-C）、高密 度脂蛋白胆固醇（high density lipoprotein-cholesterol，HDL-C）水平比较，差异无统计学意义；实验组2hPG 水平高于对照组，实验组髂总静脉、髂内静脉、股总静脉、腘静脉的内径大于对照组，实验组髂总静 脉、髂内静脉、股总静脉、腘静脉的峰值流速低于对照组，比较差异均有统计学意义（P＜0.05）。 结论 缺血性卒中伴餐后高血糖患者下肢静脉血流速度变慢，内径也相应变大，会增加下肢静脉 血栓发生风险，不利于患者预后。

关键词: 缺血性卒中; 餐后高血糖; 下肢静脉; 血流动力学