Advance in Protective Factors and Biochemical Risk Factors of Post-stroke Disability

doi:10.3969/j.issn.1673-5765.2019.03.021

Abstract

Abstract:

Stroke is a common disease which is harmful to human health, with a high incidence, mortality and disability. This article reviewed that the main protective factors and biochemical risk factors of post-stroke disability. The protective factors were discussed from three aspects: biological factors, psychological and behavioral factors and environmental factors, to provide theoretical basis and reference for establishing effective intervention measures and health management model for post-stroke disabled patients.

Key words: Stroke; Disability; Protective factor; Risk factor

摘要：

卒中是常见的心脑血管病，具有发病率、死亡率和致残率均高的特点，已成为危害人类健康最主要疾病之一。文章综述了卒中后残疾的主要保护因素和生化相关危险因素，其中保护因素分别从生物学因素，心理、行为因素和环境因素三方面汇总，为建立卒中后残疾患者干预及健康管理模式提供思路及理论依据。

关键词: 卒中; 残疾; 保护因素; 危险因素

HE Yu-Di, LYU Yu-Mei. Advance in Protective Factors and Biochemical Risk Factors of Post-stroke Disability[J]. Chinese Journal of Stroke, 2019, 14(03): 293-296.

何宇迪，吕雨梅. 卒中后残疾保护因素及生化相关危险因素研究进展[J]. 中国卒中杂志, 2019, 14(03): 293-296.

References

[1] GADIDI V，KATZLEURER M，CARMELI E，et al.

Long-term outcome poststroke：predictors of activity

limitation and participation restriction[J]. Arch Phys

Med Rehabil，2011，92（11）：1802-1808.

[2] 黄美媚，李国兴，游文霞，等. 血清白蛋白水平对急

性缺血性脑卒中患者预后的研究[J]. 中国医药指南，

2015，13（35）：52-53.

[3] 刘翠梅，王爱红. 入院血清白蛋白水平对缺血性脑卒

中患者预后影响的Meta分析[J]. 护理学杂志，2014，

29（5）：20-22.

[4] 张婧. 英国卒中国家指南关于吞咽、喂食和营养的管

理指南简介[J]. 中国卒中杂志，2007，2（3）：265.

[5] 王洪伟. 血脂水平与脑卒中的关系研究[J]. 中国医药

科学，2016，6（18）：201-203.

[6] YEH P S，YANG C M，LIN S H，et al. Low levels of

high-density lipoprotein cholesterol in patients with

atherosclerotic stroke：a prospective cohort study[J].

Atherosclerosis，2013，228（2）：472-477.

[7] ARSALAN，ISMAIL M，KHATTAK M B，et

al. Prognostic significance of serum bilirubin in

stroke[J]. J Ayub Med Coll Abbottabad，2011，23（2）：

104-107.

[8] LUO Y，LI J，ZHANG J，et al. Elevated bilirubin

after acute ischemic stroke linked to the stroke

severity[J]. Int J Dev Neurosci，2013，31（7）：634-

638.

[9] 郑舟军，刘晓虹，张丽平，等. 脑卒中患者自我效能水

平与其肢体功能康复进程的相关研究[J]. 中华护理

杂志，2012，47（5）：440-442.

[10] BONETTI D，JOHNSTON M. Perceived control

predicting the recovery of individual-specific

walking behaviours following stroke：testing

psychological models and constructs[J]. Br J Health

Psychol，2008，13（Pt 3）：463-478.

[11] DANKS K A，POHLIG R T，ROOS M，et

al. Relationship Between Walking Capacity，

Biopsychosocial Factors，Self-efficacy，and Walking

Activity in Persons Poststroke[J]. J Neurol Phys Ther，

2016，40（4）：232-238.

[12] WATKINS C L，WATHAN J V，LEATHLEY M

J，et al. The 12-month effects of early motivational

interviewing after acute stroke：a randomized

controlled trial[J]. Stroke，2011，42（7）：1956-1961.

[13] ZUFLACHT J P，SHAO Y，KRONISH I M，et al.

Psychiatric hospitalization increases short-term risk

of stroke[J]. Stroke，2017，48（7）：1795-1801.

[14] YI L，HUI L，JING W，et al. Variable lengths of

stay among ischemic stroke subtypes in Chinese

general teaching hospitals[J/OL]. Plos One，2012，

7（9）：e45101. https：//doi.org/10.1371/journal. pone.0045101.

[15] 于宁，高雅然，高燕军. 住院天数与急性缺血性脑卒

中出院不良结局的关系[J]. 脑与神经疾病杂志，2015，

23（3）：197-201.

[16] LAWRENCE M，KERR S，MCVEY C，et al. The

effectiveness of secondary prevention lifestyle

interventions designed to change lifestyle behavior

following stroke：summary of a systematic review[J].

Int J Stroke，2012，7（3）：243-247.

[17] JAUCH E C，SAVER J L，JR A H，et al. Guidelines

for the early management of patients with acute

ischemic stroke：a guideline for healthcare

professionals from the American Heart Association/

American Stroke Association[J]. Stroke，2013，

44（3）：870-947.

[18] KUMAGAI N，OKUHARA Y，IIYAMA T，et

al. Effects of smoking on outcomes after acute

atherothrombotic stroke in Japanese men[J]. J Neurol

Sci，2013，335（1-2）：164-168.

[19] DE W L，PUTMAN K，DEVOS H，et al. Long-term

prediction of functional outcome after stroke using

single items of the Barthel Index at discharge from

rehabilitation centre[J]. Disabil Rehabil，2014，

36（5）：353-358.

[20] LIU N，CADILHAC D A，ANDREW N E，et al.

Randomized controlled trial of early rehabilitation

after intracerebral hemorrhage stroke：difference in

outcomes within 6 months of stroke[J]. Stroke，2014，

45（12）：3502-3507.

[21] 陈大为，白定群. 早期康复训练干预对脑卒中患者

神经、运动功能及生活质量的影响[J]. 中国老年学，

2017，37（11）：2692-2693.

[22] 周志英. 家庭支持对脑卒中患者抑郁情绪和生活质

量的影响[J]. 中国康复理论与实践，2012，18（2）：

126-127.

[23] 邹光莉. 家庭支持对脑卒中早期肢体康复的影响[J].

中国现代药物应用，2015（8）：181-183.

[24] HUANG C Y，HSU M C，HSU S P，et al. Mediating

roles of social support on poststroke depression and

quality of life in patients with ischemic stroke[J]. J

Clin Nurs，2010，19（19-20）：2752-2762.

[25] GLASS T A，MATCHAR D B，BELYEA M，et al.

Impact of social support on outcome in first stroke[J].

Stroke，1993，24（1）：64-70.

[26] MCCULLY K S. Vascular pathology of

homocysteinemia：implications for the pathogenesis

of arteriosclerosis[J]. Am J Pathol，1969，56（1）：

111-128.

[27] ZHONG C，LV L，LIU C，et al. High homocysteine

and blood pressure related to poor outcome of acute

ischemia stroke in Chinese population[J/OL]. Plos

One，2014，9（9）：e107498. https：//doi.org/10.1371/

journal.pone.0107498.

[28] Tu W J，Zhao S J，Liu T G，et al. Combination of

high-sensitivity C-reactive protein and homocysteine

predicts the short-term outcomes of Chinese patients

with acute ischemic stroke[J]. Neurol Res，2013，

35（9）：912-921.

[29] SAXENA A，ANDERSON C S，WANG X，et al.

Prognostic significance of hyperglycemia in acute

intracerebral hemorrhage：the INTERACT2 study[J].

Stroke，2016，47（3）：682-688.

[30] YAO M，NI J，ZHOU L，et al. Elevated fasting

blood glucose is predictive of poor outcome in nondiabetic

stroke patients：a sub-group analysis of

SMART[J/OL]. Plos One，2016，11（8）：e0160674.

https：//doi.org/10.1371/journal.pone.0160674.

[31] SWAROWSKA M，JANOWSKA A，POLCZAK A，

et al. The sustained increase of plasma fibrinogen

during ischemic stroke predicts worse outcome

independently of baseline fibrinogen level[J].

Inflammation，2014，37（4）：1142-1147.

[32] DEL-ZOPPO G，LEVY D W，PANCIOLI A，et

al. Hyperfibrinogenemia and functional outcome

from acute ischemic stroke[J]. Stroke，2009，40（5）：

1687-1691.

[33] LÖPPÖNEN P，QIAN C，TETRI S，et al. Predictive

value of C-reactive protein for the outcome after

primary intracerebral hemorrhage[J]. J Neurosurg，

2014，121（6）：1374-1379.

[34] GENG H H，WANG X W，FU R L，et al. The

relationship between C-reactive protein level and

discharge outcome in patients with acute ischemic

stroke[J]. Int J Environ Res Public Health，2016，

13（7）：636-647.

[35] ZHANG W，ZHANG X A. Prognostic value of

serum lipoprotein（a）levels in patients with acute

ischemic stroke[J]. Neuroreport，2014，25（4）：262-

266.

[36] ZHANG X，HUANG Z C，LU T S，et al. Prognostic

significance of uric acid levels in ischemic stroke

patients[J]. Neurotox Res，2016，29（1）：10-20.