Progress of Relationship between Serum Biomarkers and Cerebral Small Vessel Disease

doi:10.3969/j.issn.1673-5765.2019.11.012

Abstract

Abstract:

It is currently believed that the main mechanism of cerebral small vessel disease (CSVD) is vascular endothelial injury, which is closely related to inflammation. Serum endothelial injury and inflammatory biomarkers are the most direct and simple methods to reflect endothelial injury. Studies on biomarkers will help us to further understand the pathogenesis of CSVD. Many studies have shown that inflammatory and endothelial injury biomarkers are closely related to the occurrence and development of CSVD. In addition, the relationship between inflammation and CSVD may be affected by race, genetics, and etc. This article reviewed the progress of relationship between serum vascular endothelial injury markers, inflammatory markers and different imaging markers of CSVD.

Key words: Cerebral small vessel disease; Endothelial cell; Inflammation; Biomarker

摘要：

目前认为脑小血管病（cerebral small vessel disease，CSVD）的主要机制是血管内皮损伤，而炎症和血管内皮损伤密切相关，血清中血管内皮损伤相关标志物及炎性标志物是反映炎症损伤血管内皮最直接、最简便的方法。关于生物标志物的研究为更深入了解CSVD的发生发展机制提供了重要的途径。目前多项研究表明炎性及血管内皮损伤相关标志物与CSVD的发生、发展关系密切。另外炎症与CSVD关系也可能受到人种、遗传等因素的影响。本文就血清中血管内皮相关标志物、炎性标志物与 CSVD不同影像学标志的相关性研究进展进行综述。

关键词: 脑小血管病; 内皮细胞; 炎症; 生物标志物

ZHONG Xi, WANG Yi-Long. Progress of Relationship between Serum Biomarkers and Cerebral Small Vessel Disease[J]. Chinese Journal of Stroke, 2019, 14(11): 1140-1145.

钟曦, 王伊龙. 血清生物标志物与脑小血管病关系研究进展[J]. 中国卒中杂志, 2019, 14(11): 1140-1145.

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