Progress of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in the Treatment of Ischemic Stroke

doi:10.3969/j.issn.1673-5765.2021.08.017

Abstract

Abstract: Dyslipidemia is closely related to atherosclerosis development and ischemic stroke, and lower level of LDL-C can effectively reduce the risk of cardiovascular and cerebrovascular diseases. Proprotein convertase subtilisin/kexin type 9 (PCSK 9) is a novel therapeutic target for reducing LDL-C level. PCSK 9 inhibitors can significantly reduce the level of LDL-C, and inhibit the progression of atherosclerosis. Clinical studies have shown that the PCSK9 inhibitors can significantly reduce the incidence of atherosclerotic cardiovascular events and ischemic stroke, and the genetic polymorphism of PCSK9 is closely related to hypercholesterolemia, atherosclerosis and ischemic stroke.

Key words: Proprotein convertase subtilisin/kexin type 9 inhibitor; Ischemic stroke; Lowdensity lipoprotein cholesterol; Lipid metabolism; Gene polymorphism

摘要： 血脂异常与动脉粥样硬化的发展及缺血性卒中事件的发生有密切关联，较低水平的 LDL-C可以有效降低心脑血管疾病风险。前蛋白转化酶枯草溶菌素Kexin 9型（proprotein convertase subtilisin/kexin type 9，PCSK9）是一种全新的降低LDL-C的治疗靶点，PCSK9抑制剂可以显著降低血液中LDL-C水平，并可延缓动脉粥样硬化进程。临床研究表明使用PCSK9抑制剂的患者动脉粥样硬化性心血管疾病和缺血性卒中事件发生率显著降低；另外，PCSK9基因多态性与高胆固醇血症、动脉粥样硬化及缺血性卒中密切相关。

关键词: 前蛋白转化酶枯草溶菌素Kexin 9型抑制剂; 缺血性卒中; 低密度脂蛋白胆固醇; 脂质代谢; 基因多态性

DENG Qi-Le, WU Jie-Hong, CHEN Ji-Xiang. Progress of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in the Treatment of Ischemic Stroke[J]. Chinese Journal of Stroke, 2021, 16(08): 850-854.

邓奇乐, 吴介洪, 陈吉相. 前蛋白转化酶枯草溶菌素Kexin 9型抑制剂在缺血性卒中治疗中的研究进展[J]. 中国卒中杂志, 2021, 16(08): 850-854.

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