Abstract: Objective To conduct bibliometric analysis of ischemic stroke studies published in China and the United States (US) from 2010 to 2020, display the main research forces and outstanding scholars in the field of ischemic stroke in the two countries, and compare the hot spots of ischemic stroke research between China and US, so as to provide research ideas and reference for subsequent scholars in this field. Methods Based on the core collection database of Web of Science, English literature published from China and US between 2010 and 2020 were retrieved using the subject word of ischemic stroke. The bibliometric analysis was used to analyze the types, institutions and journals of

publications. For the original contributions, the cluster analysis based on CiteSpace software was

performed to analyze the research characteristics in this field between China and US. The citation analysis was performed for the reference using the four literature evaluation indexes, including citation frequency, emergence value, centrality and Sigma, to analyze the main research forces, hot spots, etc. Results From 2010 to 2020, the number of publications published by Chinese scholars in the field of ischemic stroke increased year by year, with a total of 13 109 SCI articles published. The number of publications by American scholars showed a fluctuating increase, with a total of 21 706 published. The median journals of the top 10 publications of Chinese scholars were located in Q2, with an impact factor of 2.815. The median journals of the top 10 publications of American scholars were located in Q1, with an impact factor of 5.282. Capital Medical University was the main research institution in China, while Harvard University and the University of California system were the main research institutions in the US. Cluster analysis showed that the most common concerned research topics by Chinese and American scholars were atrial fibrillation, neuroinflammation and thrombectomy. In addition, Chinese scholars also paid attention to acute ischemic stroke, MALAT1, mild stroke, neuroprotection, homocysteine, mortality and depression; American scholars also paid attention to thrombolysis, carotid endarterectomy, perfusion, telemedicine and stroke classification, etc., and the above research topics can become the research focus of continuous attention in the near future. Conclusions At present, the research achievements of American scholars have great influence, and Chinese scholars need to deepen the cooperation with major international research institutions. Chinese and American scholars focused on three research topics, thrombectomy, neuroinflammation and atrial fibrillation.

Key words: Ischemic stroke; China; The United States; Bibliometrics; CiteSpace software

摘要： 目的 对2010-2020年中国和美国发表的缺血性卒中研究进行文献计量分析，展示中国和美国在该 疾病领域主要研究力量、优秀学者，对比中国和美国缺血性卒中研究热点，为后续该领域的研究提供 思路和借鉴。 方法 基于Web of Science核心合集数据库，以“ischemic stroke”为主题检索词，检索2010-2020年 中国、美国发表的英文文献，采用文献计量法对发文类型、机构、期刊进行分析。选择研究论著，采 用CiteSpace软件对中国和美国在该领域的研究特征进行聚类分析。采用被引频次、突现值、中介中心 性及Sigma 4项文献评价指标对发表文章的参考文献进行被引分析，对主要研究力量、研究热点等 进行讨论。 结果 2010-2020年中国学者在缺血性卒中领域发文量逐年增长，共发表SCI文章13 109篇，美国学 者发文量波动增长，共发表21 706篇；中国学者文章刊载量前10位的出版物中位数期刊位于Q2分区， 影响因子为2.815，美国学者文章刊载量前10位的出版物中位数期刊位于Q1分区，影响因子为5.282； 中国主要研究机构为首都医科大学，美国为哈佛大学和美国加州大学系统；聚类分析显示，中美两国学 者共同最关注的研究主题有心房颤动、神经炎症和血栓切除术，另外，中国学者还关注急性缺血性卒 中、肺腺癌转移相关转录因子1、轻度卒中、神经保护、同型半胱氨酸、死亡率和抑郁情绪等，美国学者 还关注溶栓、颈动脉内膜切除手术、灌注、远程医疗及卒中分类等，以上研究主题均可成为后续关注 的研究热点。 结论 目前美国学者研究成果的影响力较大，我国学者需深化与国际主要研究机构的合作。中、美 两国学者关注的研究领域主要集中在血栓切除术、神经炎症、心房颤动三个研究主题。

关键词: 缺血性卒中; 中国; 美国; 文献计量; CiteSpace软件