Advances in Imaging Evaluation of Post-stroke Aphasia

doi:10.3969/j.issn.1673-5765.2022.09.017

Abstract

Abstract: Post-stroke aphasia is one of the important neurological deficits caused by cerebrovascular diseases, which severely affects patients' cognition and communication, even brings heavy spirit and economic burden to patients themselves, their families and the society. In recent years, with the development of functional imaging, especially functional magnetic resonance imaging has been used by many researchers to study the pathogenesis and recovery mechanism of post-stroke aphasia. This article summarized the advances in imaging research of post-stroke aphasia, in order to provide reference for exploring the pathogenesis, disease progression and recovery mechanism, and forecast the future direction of research.

Key words: Post-stroke aphasia; Functional magnetic resonance imaging; Pathogenesis; Recovery mechanism

摘要： 卒中后失语是由于脑血管病引起的神经功能缺损的重要症状之一，严重影响患者的认知和沟通，给患者、家庭和社会带来很大的精神及经济负担。近年来，功能磁共振成像被众多的研究者应用于研究卒中后失语的发病机制及恢复机制。本文综述了卒中后失语的影像学评估研究进展，旨在为探讨其发病机制、病变发展及恢复机制提供参考并展望研究方向。

关键词: 卒中后失语; 功能磁共振成像; 发病机制; 恢复机制

XU Luyao, CHEN Xiaodi, LIANG Zhigang. Advances in Imaging Evaluation of Post-stroke Aphasia [J]. Chinese Journal of Stroke, 2022, 17(09): 1017-1021.

徐璐瑶, 陈晓迪, 梁志刚. 卒中后失语的影像学评估研究进展[J]. 中国卒中杂志, 2022, 17(09): 1017-1021.

References

[1] KLINGBEIL J，WAWRZYNIAK M，STOCKERT A，et al. Resting-state functional connectivity：an emerging method for the study of language networks in post-stroke aphasia[J/OL]. Brain Cogn，2019，131：22-33[2022-01-15]. https://doi.org/10.1016/j.bandc.2017.08.005.
[2] LAZAR R M，BOEHME A K. Aphasia as a predictor of stroke outcome[J/OL]. Curr Neurol Neurosci Rep，2017，17（11）：83[2022-01-15]. https://doi.org/10.1007/s11910-017-0797-z.
[3] EL HACHIOUI H，LINGSMA H F，VAN DE SANDT-KOENDERMAN M W，et al. Long-term prognosis of aphasia after stroke[J]. J Neurol Neurosurg Psychiatry，2013，84（3）：310-315.
[4] 于可，张超，徐凯. 卒中后失语症治疗前后功能磁共振研究进展[J]. 磁共振成像，2020，11（10）：937-939.
[5] YOURGANOV G，SMITH K G，FRIDRIKSSON J，et al. Predicting aphasia type from brain damage measured with structural MRI[J/OL]. Cortex，2015，73：203-215[2022-01-15]. https://doi.org/10.1016/j.cortex.2015.09.005.
[6] FRIDRIKSSON J，DEN OUDEN D B，HILLIS A E，et al. Anatomy of aphasia revisited[J]. Brain，2018，141（3）：848-862.
[7] CAPPA S F. The neural basis of aphasia rehabilitation：evidence from neuroimaging and neurostimulation[J]. Neuropsychol Rehabil，2011，21（5）：742-754.
[8] CRINION J，HOLLAND A L，COPLAND D A，et al. Neuroimaging in aphasia treatment research：quantifying brain lesions after stroke[J/OL]. Neuroimage，2013，73：208-214[2022-01-15]. https://doi.org/10.1016/j.neuroimage.2012.07.044.
[9] DE BOER R G A，SPIELMANN K，HEIJENBROK-KAL M H，et al. The role of the BDNF Val66Met polymorphism in recovery of aphasia after stroke[J]. Neurorehabil Neural Repair，2017，31（9）：851-857.
[10] TELEB M S，VER HAGE A，CARTER J，et al. Stroke vision，aphasia，neglect（VAN）assessment-a novel emergent large vessel occlusion screening tool：pilot study and comparison with current clinical severity indices[J]. J Neurointerv Surg，2017，9（2）：122-126.
[11] IORGA M，HIGGINS J，CAPLAN D，et al. Predicting language recovery in post-stroke aphasia using behavior and functional MRI[J/OL]. Sci Rep，2021，11（1）：8419[2022-01-15]. https://doi.org/10.1038/s41598-021-88022-z.
[12] YANG M，LI J，LI Y B，et al. Altered intrinsic regional activity and interregional functional connectivity in post-stroke aphasia[J/OL]. Sci Rep，2016，6：24803[2022-01-15]. https://doi.org/10.1038/srep24803.
[13] 何雅娜，张权，张云亭，等. 脑梗死后运动性失语患者语言中枢的fMRI评价[J]. 磁共振成像，2010，1（1）：6-10.
[14] ZUO X N，XU T，JIANG L L，et al. Toward reliable characterization of functional homogeneity in the human brain：preprocessing，scan duration，imaging resolution and computational space[J/OL]. Neuroimage，2013，65：374-386[2022-01-15]. https://doi.org/10.1016/j.neuroimage.2012.10.017.
[15] ZHANG C，XIA Y Y，FENG T，et al. Disrupted functional connectivity within and between resting-state networks in the subacute stage of post-stroke aphasia[J/OL]. Front Neurosci，2021，15：746264[2022-01-15]. https://doi.org/10.3389/fnins.2021.746264.
[16] CHANDRA A，DERVENOULAS G，POLITIS M. Magnetic resonance imaging in Alzheimer's disease and mild cognitive impairment[J]. J Neurol，2019，266（6）：1293-1302.
[17] RYMAN S G，POSTON K L. MRI biomarkers of motor and non-motor symptoms in Parkinson's disease[J/OL]. Parkinsonism Relat Disord，2020，73：85-93[2022-01-15]. https://doi.org/10.1016/j.parkreldis.2019.10.002.
[18] PRICE C J. The anatomy of language：a review of 100 fMRI studies published in 2009[J/OL]. Ann N Y Acad Sci，2010，1191：62-88[2022-01-15]. https://doi. org/10.1111/j.1749-6632.2010.05444.x.
[19] CRINION J T，LEFF A P. Using functional imaging to understand therapeutic effects in poststroke aphasia[J]. Curr Opin Neurol，2015，28（4）：330-337.
[20] STOCKERT A，WAWRZYNIAK M，KLINGBEIL J，et al. Dynamics of language reorganization after left temporo-parietal and frontal stroke[J]. Brain，2020，143（3）：844-861.
[21] BROWNSETT S L，WARREN J E，GERANMAYEH F，et al. Cognitive control and its impact on recovery from aphasic stroke[J/OL]. Brain，2014，137（Pt 1）：242-254[2022-01-15]. https://doi.org/10.1093/brain/awt289.
[22] GERANMAYEH F，BROWNSETT S L，WISE R J. Task-induced brain activity in aphasic stroke patients：what is driving recovery?[J/OL]. Brain，2014，137（Pt 10）：2632-2648[2022-01-15]. https://doi.org/10.1093/brain/awu163.
[23] FREGNI F，PASCUAL-LEONE A. Technology insight：noninvasive brain stimulation in neurology-perspectives on the therapeutic potential of rTMS and tDCS[J]. Nat Clin Pract Neurol，2007，3（7）：383-393.
[24] DI PINO G，PELLEGRINO G，ASSENZA G，et al. Modulation of brain plasticity in stroke：a novel model for neurorehabilitation[J]. Nat Rev Neurol，2014，10（10）：597-608.
[25] SHAH P P，SZAFLARSKI J P，ALLENDORFER J，et al. Induction of neuroplasticity and recovery in post-stroke aphasia by non-invasive brain stimulation[J/OL]. Front Hum Neurosci，2013，7：888[2022-01-15]. https://doi.org/10.3389/fnhum.2013.00888.
[26] GUO J，YANG M，BISWAL B B，et al. Abnormal functional connectivity density in post-stroke aphasia[J]. Brain Topogr，2019，32（2）：271-282.
[27] XU X L，REN C L，FANG H，et al. Exploring the functional connectivity characteristics of brain networks in post-stroke patients with global aphasia：a healthy control based resting-state fMRI study[J]. Ann Palliat Med，2021，10（12）：12113-12128.
[28] YANG M，YANG P，FAN Y S，et al. Altered structure and intrinsic functional connectivity in post-stroke aphasia[J]. Brain Topogr，2018，31（2）：300-310.
[29] SANDBERG C W. Hypoconnectivity of resting-state networks in persons with aphasia compared with healthy age-matched adults[J/OL]. Front Hum Neurosci，2017，11：91[2022-01-15]. https://doi.org/10.3389/fnhum.2017.00091.
[30] ZHAO Y，LAMBON RALPH M A，HALAI A D. Relating resting-state hemodynamic changes to the variable language profiles in post-stroke aphasia[J/OL]. Neuroimage Clin，2018，20：611-619[2022-01-15]. https://doi.org/10.1016/j.nicl.2018.08.022.
[31] SIEGEL J S，SEITZMAN B A，RAMSEY L E，et al. Re-emergence of modular brain networks in stroke recovery[J/OL]. Cortex，2018，101：44-59[2022-01-15]. https://doi.org/10.1016/j.cortex.2017.12.019.
[32] ASSAF Y，PASTERNAK O. Diffusion tensor imaging（DTI）-based white matter mapping in brain research：a review[J]. J Mol Neurosci，2008，34（1）：51-61.
[33] MARIN M A，CARMICHAEL S T. Mechanisms of demyelination and remyelination in the young and aged brain following white matter stroke[J/OL]. Neurobiol Dis，2019，126：5-12[2022-01-15]. https://doi.org/10.1016/j.nbd.2018.07.023.
[34] YAO J F，LIU X X，LU X，et al. Changes in white matter microstructure related to non-linguistic cognitive impairment in post-stroke aphasia[J]. Neurol Res，2020，42（8）：640-648.
[35] PAN J W，BEBIN E M，CHU W J，et al. Ketosis and epilepsy：31P spectroscopic imaging at 4.1 T[J]. Epilepsia，1999，40（6）：703-707.
[36] HUPPI P S，BARNES P D. Magnetic resonance techniques in the evaluation of the newborn brain[J]. Clin Perinatol，1997，24（3）：693-723.
[37] ZHANG Y M，WANG Y L，WANG C X，et al. Study on the pathogenic mechanism of Broca's and Wernicke's aphasia[J]. Neurol Res，2006，28（1）：59-65.